Science Current Events | Science News | Brightsurf.com
 

Scientists discover and test new class of pain relievers

June 01, 2016


DURHAM, N.C. -- A research team at Duke University has discovered a potential new class of small-molecule drugs that simultaneously block two sought-after targets in the treatment of pain.

These proof-of-concept experiments, published June 1 in Scientific Reports, could lead to the development of a new drug to treat conditions including skin irritation and itching, headaches, jaw pain, and abdominal pain stemming from the pancreas and colon.

More than 100 million people suffer from chronic pain in the United States, according to a report from the Institute of Medicine, and new medicines are badly needed.

"We are very pleased with what is a first chapter in a highly promising story," said Wolfgang Liedtke, M.D., Ph.D., a professor of neurology, anesthesiology and neurobiology at Duke University School of Medicine, who treats patients with head and face pain and other sensory disorders. "We hope to be able to develop these compounds for clinical use in humans or animals."

In the new study, the researchers initially aimed to develop more effective blockers of TRPV4, a molecule their previous research had shown transmits skin irritation elicited by sunburn, and painful sensations coming from the head and face. Liedtke and his Duke collaborator Farshid Guilak used a prototype TRPV4 blocker in a 2009 study and then set out to develop more potent versions.

Compared to the prototype, one of the new candidate drugs, called "16-8," worked 10 times more effectively in cells with active TRPV4 that are key for the development of osteoarthritis. It also worked well in another cell type involved in nerve cell injury, stroke and epilepsy.

But to their surprise, when assessing the specificity of 16-8, the scientists discovered that it also blocked TRPA1, which is a promising target in pain and itch research.

"As a physician, I soon realized the enormous potential that these compounds might have, given how beneficial dual-target molecules can be in clinical medicine," Liedtke said.

Both TRPV4 and TRPA1 are members of the family of TRP ion channels, which function in sensory nerve cells to directly sense painful stimuli. Other research groups are now targeting these channels in clinical trials for pain relief.

In this study, the drug 16-8 also quelled pain in living animals, including abdominal aches in mice with pancreas inflammation. So-called pancreatitis is extremely painful and difficult to treat, and new cases are on the rise globally, said study co-author Rodger Liddle, M.D., of the Duke University School of Medicine and a member of the Duke Institute for Brain Sciences.

Liedtke sees potential for the 16-8 drug to treat osteoarthritis and other types of joint pain as well as head, face and jaw pain. In general, it might also treat aches radiating from internal organs or resulting from nerve cell injury.

The group's preclinical work will focus on understanding the compound's potential use in these conditions as well as learning more about how it works. They also hope to explore topical applications to mucous membranes, which are present throughout the body and skin.

###

The study was supported by the National Institutes of Health (DE018549, AR48182, AR48182-S1, AR48852, AG15768, AR50245, AG46927, DK064213, DK091946, DK098796, F33DE024668, K12DE022793, K12CA100639, the U.S. Department of Defense (W81XWH-13-1-0299), the U.S. Department of Veterans Affairs, the National Science Foundation (1445792), the Arthritis Foundation, and the Harrington Discovery Institute Scholar-Innovator Award. Duke's Office of Licensing and Ventures is pursuing patent applications on this work.

CITATION: " Small molecule dual-inhibitors of TRPV4 and TRPA1 for attenuation of inflammation and pain," Patrick Kanju, Yong Chen, Whasil Lee, Michele Yeo, Suk Hee Lee, Joelle Romac, Rafiq Shahid, Ping Fan, David M. Gooden, Sidney A. Simon, Ivan Spasojevic, Robert A. Mook, Rodger A. Liddle, Farshid Guilak and Wolfgang B. Liedtke. Scientific Reports, June 1, 2016. DOI: 10.1038/srep26894

Duke University


Related Pain Relievers Current Events and Pain Relievers News Articles


Standardizing care improves outcomes for infants born with neonatal abstinence syndrome
Standardizing hospital care policies across institutions for infants diagnosed with drug withdrawal symptoms at birth reduces their length of treatment and hospitalization, according to new collaborative research led by Vermont Oxford Network, Vanderbilt and the University of Michigan Health System.

Penn researchers show rising opioid prescriptions following low-risk surgeries
Physicians are prescribing more opioid painkillers than ever before to patients undergoing common surgeries, according to new research from the department of Anesthesiology and Critical Care at the Perelman School of Medicine at the University of Pennsylvania.

Many use prescription painkillers, most see abuse as major health concern
More than one in four Americans has taken prescription painkillers in the past year, even as a majority say that abuse of these medications is a very serious public health concern, according to new Johns Hopkins Bloomberg School of Public Health research.

Risk profiling is key to managing pain in era of opioid abuse
Patients undergoing rehabilitation for physical injuries and their physicians can better understand who is most at risk of abusing opioids by reviewing their family history, lifestyle and environment for critical cues about susceptibility to addiction, according to physical medicine and rehabilitation experts.

Babies with drug withdrawal syndrome more likely to be readmitted
Infants diagnosed with drug withdrawal symptoms at birth, also known as neonatal abstinence syndrome (NAS), are nearly two and a half times as likely to be readmitted to the hospital in the first month after being discharged compared with full-term infants born without complications, according to new Vanderbilt research released today in the journal Hospital Pediatrics.

Patients prefer relief from lower back pain over improved mobility
A new study out today in the journal Neurology examines the question of quality of life for individuals with a common form of lower back pain called lumbar spinal stenosis.

Stanford researchers genetically engineer yeast to produce opioids
For thousands of years, people have used yeast to ferment wine, brew beer and leaven bread.

Model could help counteract poisoning from popular painkiller
New research could help reverse deadly side effects caused by excessive doses of the drug acetaminophen, the major ingredient in Tylenol and many other over-the-counter and prescription medicines.

Seniors don't bounce back fast from car crashes
Many seniors injured in motor vehicle crashes remain in pain for months afterwards, which negatively affects their quality of life, including the ability to live independently.

Emergency department opioid prescribing
The Emergency Department (ED) is at the convergence of the opioid epidemic as emergency physicians (EPs) routinely care for patients with adverse effects from opioids, including overdoses and those battling addiction, as well as treating patients that benefit from opioid use.
More Pain Relievers Current Events and Pain Relievers News Articles

Project Pain Reliever: A Just-In-Time Handbook for Anyone Managing Projects

Project Pain Reliever: A Just-In-Time Handbook for Anyone Managing Projects
by Dave Garrett (Author), Dave Garrett (Editor)


Although a valuable reference for all project managers, this handbook was developed primarily for new and accidental project managers who manage projects as part of their role and not their profession. These project managers often lack the training or experience to effectively address many of the problems faced by seasoned project management professionals. Project Pain Reliever is uniquely organized in essentially a plug-and-play format designed to help these project managers quickly find specific solutions to the problems that they are desperate to fix right now!

Key Features:

--Covers both the art and science of project management and is organized by problem so that users need only review the table of contents, find their problem within a sub-chapter heading, read...

Learn How to Treat the Knee Pain: Know the Right Knee Pain Diagnosis!

Learn How to Treat the Knee Pain: Know the Right Knee Pain Diagnosis!


This Book “Learn How to Treat the Knee Pain: Know the Right Knee Pain Diagnosis!” is the best guide for you to learn all about knee pain and its causes so you can get the right treatment. A lot of people face knee problems, but are not aware of how to fix it. They immediately seek a doctor's advice because they do not realize that they can learn the knee pain diagnosis themselves.

It is very easy to know how to treat knee pain if you have a minor injury or normal pain. We develop knee pain because of age and our body movements. Everyone can learn about their body and understand what causes their pain. When you have enough information about knee pain, you will be able to fix it yourself (unless it is chronic or severe).

The following chapters which will help...

Herbal Cures: 24 Herbs for Healing and Relieving Pain: Herbal Cures, Herbal Remedies, Organic Remedies, Pain Relievers, Natural Remedies

Herbal Cures: 24 Herbs for Healing and Relieving Pain: Herbal Cures, Herbal Remedies, Organic Remedies, Pain Relievers, Natural Remedies
by Dr. Marlena T. Lamai (Author)


Herbal Cures: 24 Herbs for Healing and Relieving Pain Herbal medicine is a form of health maintenance that can build a reputation of its own or can be a part of a more complicated health care method. It is recorded to be the oldest form of cure and therapy in the history of medicine and been practiced since ancient times in every culture throughout the world. It has been a vital part of medicine development. Although it’s old, most of it is still practiced today because of its proven and effective performance.

Turmeric: The Natural Arthritis Pain Reliever and So Much More...

Turmeric: The Natural Arthritis Pain Reliever and So Much More...
by Mary Criswell-Carpenter (Author)


This book includes the current research for medicinal uses of turmeric, and its active ingredient, curcumin. Turmeric has been proven to help in the following disease processes: Indigestion or heartburn Ulcerative colitis Osteoarthritis Atherosclerosis Cancer Bacterial and viral infections Uveitis Neurodegenerative conditions like Alzheimer's Disease Diabetes This book is to inform consumers of the newest research on Turmeric/curcumin. This is not medical advice nor does it claim to be. Some of these studies were performed on rodents or in a test tube and may not have the same results for humans.

PEPPERMINT ESSENTIAL OIL THE #1 MOST POWERFUL ENERGY OIL IN AROMATHERAPY: Research Studies Prove Effectiveness, Focus, Pay Attention & Stay Alert, Cools ... Pain Reliever (Healing with Essential Oil)

PEPPERMINT ESSENTIAL OIL THE #1 MOST POWERFUL ENERGY OIL IN AROMATHERAPY: Research Studies Prove Effectiveness, Focus, Pay Attention & Stay Alert, Cools ... Pain Reliever (Healing with Essential Oil)
by http://www.kgstiles.com


PEPPERMINT ESSENTIAL OIL is a quick and helpful reference guide you can rely on for knowing when to choose Peppermint as your healing tool to relieve specific symptoms of imbalance and promote healing.

You’ll learn the healing properties of Peppermint pure essential oil, including plant identification with Latin name so you’ll know the botanical species to select for getting therapeutic results, along with the preferred distillation method, part of plant used, and some of the best locations for production and distillation, as well as distinguishing aromatic qualities of pure, unadulterated peppermint oil.

You’ll find out why peppermint essential oil is the #1 most powerful ‘energy’ oil in aromatherapy and what research studies show conclusively about...

  All Natural Pain Relievers
by Carlson Wade (Author), William S. Keezer (Foreword)




Vicodin, OxyContin, and Other Pain Relievers (Junior Drug Awareness)

Vicodin, OxyContin, and Other Pain Relievers (Junior Drug Awareness)
by Amy E Breguet (Author), Ronald J Brogan (Introduction)


'Vicodin, OxyContin, and Other Pain Releivers' gives readers the inside story on this notorious class of drugs and offers suggestions to help people affected negatively by abuse of these drugs.

Natural Pain Killers That Work! Relieve Chronic Headaches, Migraines, Neck, Upper and Lower Back Pain, and Other Common Pains with Mother Nature's All Natural Pain Remedies

Natural Pain Killers That Work! Relieve Chronic Headaches, Migraines, Neck, Upper and Lower Back Pain, and Other Common Pains with Mother Nature's All Natural Pain Remedies


Learn How To Eliminate Your Chronic Pain With All-Natural Pain Killers That REALLY WORK! Do you suffer from chronic pain? If you do, you're not alone -- a recent study found that 1.5 BILLION people, worldwide, suffer from chronic pain. Chronic pain is debilitating and interferes with your ability to work, to play with your children, to enjoy things that you love to do, and even your ability to take care of yourself if the pain is severe enough. It can limit your mobility and lead to depression over time.

Easing Your Pain The Natural Way
So what can you do to ease your pain without having to take dangerous synthetic pain medication that often come with an array of adverse side effects? Let Mother Nature help ease your pain! Natural, plant-based pain killers are highly...

End Pain & Feel Great Again!: Nineteen Proven Body, Mind, Spirit, and Fun Ways to Banish Pain Naturally

End Pain & Feel Great Again!: Nineteen Proven Body, Mind, Spirit, and Fun Ways to Banish Pain Naturally
by Duncan Tooley CHI (Author)


Your mind is running your body!
You can switch off your pain by taking control of the pain center part of your mind.
This book shows you 19 ways to feel great again, pain free without drugs or side-effects. It teaches you step-by-step how to use the power you already have to feel great and get your life back!

Duncan Tooley catalogs the natural mind-over-body pain relief methods that have worked for his clients and that are backed by medical studies.

The easy-to-learn and easy-to-use techniques comes from Tooley’s discovery of the power of the mind documented in thousands of medical studies and demonstrated by his hundreds of clients who have turned off their pain and got their joyous life back.

Any single one of these techniques may be all that you...

1,000 Word Book: BACK-PAIN CURES: 15 Back Pain Solutions You Probably Never Heard About... Learn and Apply in 5 Minutes or Less

1,000 Word Book: BACK-PAIN CURES: 15 Back Pain Solutions You Probably Never Heard About... Learn and Apply in 5 Minutes or Less


Cure Your Back Pain ASAP!

Learn back pain solutions that most people didn't know exist!

You can read this book in less than 10 minutes and you can spend more time taking action rather than reading.

Reading won't cure your back-pain.

These solutions will!

Download your copy today!

© 2017 BrightSurf.com