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Concern over clinical value of new mood disorder drugs
July 16, 2003Recent changes to the classification of psychiatric disorders are encouraging pharmaceutical companies to develop new drugs that are of questionable clinical value, argue researchers in this week’s BMJ.
Since 1980, anxiety and depression have been split into separate diseases. Drug development has subsequently been tailored to new “niche” diagnoses such as panic, social anxiety disorder, and post-traumatic stress disorder.
The proliferation of niche diagnoses is liked by industry because it creates new licensing opportunities for phoney new drugs, but it has also led to a slowdown in production of drugs for the most common psychiatric disorder of mixed anxiety and depression, write the authors.
“We believe that the failure to advance the treatment of anxiety and depression is related to wrong classification,” say the authors.
Companies must start developing drugs for mixed anxiety and depression and forget about dividing this giant illness segment into salami slices. Doctors could encourage this change by being more cynical about pitches from drug representatives claiming to have “the latest” medication to reduce anxiety, they conclude.
British Medical Journal (BMJ)
“We believe that the failure to advance the treatment of anxiety and depression is related to wrong classification,” say the authors.
Companies must start developing drugs for mixed anxiety and depression and forget about dividing this giant illness segment into salami slices. Doctors could encourage this change by being more cynical about pitches from drug representatives claiming to have “the latest” medication to reduce anxiety, they conclude.
British Medical Journal (BMJ)
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Depression Current Events and Depression News RSSRutgers Research: Parkinson's Disease Alters Patient's Ability to Learn from Rewards while Treatment Affects Ability to Learn from Negative Outcomes
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Poor sleep is independently associated with depression in postpartum women
A study in the July 1 issue of the journal SLEEP suggests that postpartum depression may aggravate an already impaired sleep quality, as experiencing difficulties with sleep is a symptom of depression.
Mayo Clinic Proceedings reviews deep brain stimulation to treat psychiatric diseases
Pioneering therapeutic trials to investigate the effectiveness of deep brain stimulation (DBS) in hard-to-treat depression, obsessive-compulsive disorder (OCD) and Tourette's syndrome are underway at multiple medical centers around the world.
Patients with moderate to severe periodontitis need evaluation for heart disease risk
Additional research is called for and patients with moderate to severe periodontitis should receive evaluation and possible treatment to reduce their risk of atherosclerotic cardiovascular disease (CVD).
U-M study finds voice box can be preserved, even with the largest cancers
Some patients with large tumors on their larynx can preserve their speech by opting for chemotherapy and radiation over surgery to remove the voice box.
Irritability should be considered when diagnosing bipolar disorder in children
A new study from Bradley Hospital and The Warren Alpert Medical School of Brown University, as well as two other institutions, adds to mounting evidence that clinicians consider irritability as a symptom when diagnosing pediatric bipolar disorder.
Marking anorexia with a brain protein
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Care Management Reduces Depression and Suicidal Thoughts in Older Primary Care Patients
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Mouse model of Parkinson's reproduces nonmotor symptoms
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