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COMET results released at Heart Failure / ISHR-ES 2003 support superiority of carvedilol in the treatment of chronic heart failure in major European trial
June 23, 2003Monday 23 June 2003, Strasbourg, France: According to results presented today at the Heart Failure / ISHR-ES 2003, the non-selective beta blocking agent carvedilol is more effective in the treatment of patients with chronic heart failure than the '¢-1 selective beta blocker metoprolol.
These results were presented at this morning's Hot Line Session at Heart Failure / ISHR-ES 2003, the meeting of the European Society of Cardiology's Working Group on Heart Failure, held jointly this year with the Annual Congress of the European Section of the International Society for Heart Research.
COMET, The Carvedilol or Metoprolol European Trial (COMET), is the largest and longest study to date in chronic heart failure and the first head-to-head survival study comparing two beta blocking agents in patients with chronic heart failure, including more than 14,000 patient years of follow-up across 15 European countries. Beta-blocking agents are recommended in the ESC Guidelines for the treatment of mild, moderate and severe chronic heart failure.
Professor John Cleland, University of Hull, UK, member of the COMET Steering Committee and a Fellow of the ESC, comments, "This is a major European trial which will help doctors deliver improved care for their patients. It is the first time two agents for heart failure have been compared, head to head, in a large outcome study. And the results show a substantial difference between the two. For less than one euro per day, carvedilol increased life expectancy by almost 1.5 years - an effect greater than that of coronary artery bypass surgery for three vessel coronary disease".
On the implications of the results, Professor Cleland continues, "These results will lead to a real benefit for patients and a rationalization of their treatment. COMET is a landmark study in heart failure and should take its place amongst the top 20 studies that are the basis for modern clinical management of heart failure. The medical community should now implement the findings of the study".
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European Society of Cardiology (ESC)
Professor John Cleland, University of Hull, UK, member of the COMET Steering Committee and a Fellow of the ESC, comments, "This is a major European trial which will help doctors deliver improved care for their patients. It is the first time two agents for heart failure have been compared, head to head, in a large outcome study. And the results show a substantial difference between the two. For less than one euro per day, carvedilol increased life expectancy by almost 1.5 years - an effect greater than that of coronary artery bypass surgery for three vessel coronary disease".
On the implications of the results, Professor Cleland continues, "These results will lead to a real benefit for patients and a rationalization of their treatment. COMET is a landmark study in heart failure and should take its place amongst the top 20 studies that are the basis for modern clinical management of heart failure. The medical community should now implement the findings of the study".
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European Society of Cardiology (ESC)
Heart Failure Current Events and Heart Failure News RSSUniversity of Minnesota invention will help speed development of drug treatments for heart failure
Research conducted by University of Minnesota scientists, in collaboration with Celladon Corporation, has led to the invention of technology to more rapidly identify compounds for the treatment of heart failure.
New tool for helping pediatric heart surgery
A team of researchers at the University of California, San Diego and Stanford University has developed a way to simulate blood flow on the computer to optimize surgical designs.
Carvedilol shown to have unique characteristics among beta blockers
In a new study, researchers report that a class of heart medications called beta-blockers can have a helpful, or harmful, effect on the heart, depending on their molecular activity.
High Blood Pressure Easy to Miss in Children with Kidney Disease
Spot blood pressure readings in children with chronic kidney disease often fail to detect hypertension - even during doctor's office visits - increasing a child's risk for serious heart problems, according to research from Johns Hopkins Children's Center and other institutions. A report of the findings appears online in the Journal of American Society of Nephrology.
Inhibition of GRK2 is protective against acute cardiac stress injuries
Inhibition of a protein known to contribute to heart failure also appears to be protective of the heart in more acute cardiac stress injury, namely ischemia reperfusion.
Young athletes need dual screening tests for heart defects, study suggests
To best detect early signs of life-threatening heart defects in young athletes, screening programs should include both popular diagnostic tests, not just one of them, according to new research from heart experts at Johns Hopkins.
Protein changes in heart strengthen link between Alzheimer's disease and chronic heart failure
A team of U.S., Canadian and Italian scientists led by researchers at Johns Hopkins report evidence from studies in animals and humans supporting a link between Alzheimer's disease and chronic heart failure, two of the 10 leading causes of death in the United States.
Elevated biomarkers lead to diminished quality of life in heart attack patients post-discharge
Many heart attack patients have high levels of cardiac biomarkers in the blood for several months after leaving the hospital, with more shortness of breath and chest pain, according to a Henry Ford Hospital study.
Tiny particles can deliver antioxidant enzyme to injured heart cells
Researchers at Emory University and the Georgia Institute of Technology have developed microscopic polymer beads that can deliver an antioxidant enzyme made naturally by the body into the heart.
New study links vitamin D deficiency to cardiovascular disease and death
While mothers have known that feeding their kids milk builds strong bones, a new study by researchers at the Heart Institute at Intermountain Medical Center in Salt Lake City suggests that Vitamin D contributes to a strong and healthy heart as well - and that inadequate levels of the vitamin may significantly increase a person's risk of stroke, heart disease, and death, even among people who've never had heart disease.
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Holy Heart Failure by Holy Heart Failure | |
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LifeMasters {Heart Failure Treatment: Getting Started, Understanding Heart Failure Medications} Also With: LifeMasters (Producer) *** HEART FAILURE TREATMENT: GETTING STARTED - This video shows you how taking an active role in treatment can help you improve your quality of life and stay out of the hospital. It outlines a basic treatment plan and ecnourages you to work with your LifeMasters nurse to make the goals of treatment personal and realistic. UNDERSTANDING HEART FAILURE MEDICATIONS - Using patient testimonials, this program shows you how the medications available today make heart failure a manageable condition. It covers the main classifications of drugs, their side effects, and possible dosage adjustments. Practical tips to help you organize multiple medications are included. *** | |
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Congestive Heart Failure Awareness Ribbon Mouse Pad by MyHeritageWear.com The Congestive Heart Failure Ribbon proudly displayed on a mouse pad. There is no better way to achieve awareness for the meaning of the Congestive Heart Failure Ribbon than to display it on your mouse pad for everyone to see. The mouse pad measures at 9.25 x 7.75, it is machine washable, and the colors will not fade or run. Start gaining awareness today by presenting your Congestive Heart Failure Ribbon mouse pad at work or at home. It is certain to keep your mouse rolling in style all while gaining support and awareness! |
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