How Long Should Drug Treatment Of Depression Last?May 26, 2003Three Italian researchers (Drs Fava, Ruini and Tossani of the University of Bologna) challenge the Australian guidelines for treatment of depression. The beyondblue guidelines for treating depression in primary care by Ellis and Smith are intended to assist both healthcare professionals and consumers. While they provide several helpful indications, they also include some misleading suggestions. The authors state that drug treatment of depression should continue for at least one year for a first episode of depression, and at least two years for repeated episodes or when there are other risk factors for relapse. Maintenance pharmacotherapy has been advocated as an effective tool for reducing relapses and recurrences in major depression. Duration of drug treatment, however, did not seem to affect long-term prognosis once treatment with the drug was discontinued. In fact, after recovery from an index episode of major depression, risk of postdiscontinuation relapse was nearly significantly greater after longer treatment (? = 0.37; P = 0.052).Further, Ellis and Smith fail to mention a vexing clinical problem in maintenance antidepressant treatment: the return of depressive symptoms. However, there is a promising alternative. Treatment of depression by pharmacological means is likely to leave substantial residual symptoms. In randomised controlled trials, cognitive behavioural treatment of residual symptoms was found to significantly improve long-term outcome of recurrent depression and to allow discontinuation of drug therapy. Preventing recurrence in major depression cannot simply be based on prolonging ongoing pharmacological treatment. The belief that a longer course of treatment will result in a more favourable outcome after discontinuation of antidepressant drug therapy is not supported by research evidence. Active collaboration with the patient (in choosing a treatment option, in lifestyle modification, in seeking treatment again when needed) is a crucial, and yet neglected, variable. It can lead to a more rational use of antidepressant drugs and to therapeutic efforts of more enduring quality than those prevailing today. The debate underlies the role of pharmaceutical industry in professional guidelines. Psychotherapy and Psychosomatics, Journal of |
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| Related Depression Current Events and Depression News Articles Burnout and mental distress strongly related to errors by US surgeons Major medical errors self-reported by American surgeons are strongly related to both burnout and depression. Those findings appear today in the online edition of Annals of Surgery. The Mayo Clinic-led study included collaborators from Johns Hopkins and the American College of Surgeons. Mother's Depression a Risk Factor in Childhood Asthma Symptoms, Study Suggests Asthma symptoms can worsen in children with depressed mothers, according to research from Johns Hopkins Children's Center published online in the Journal of Pediatric Psychology. Dispensing prescription drugs in 3-month supplies reduces drug costs by a third Purchasing prescription drugs in a three-month supply rather than a one-month supply has long been regarded as a way to reduce the cost of drugs for patients and third-party payers. New research from the University of Chicago quantifies the savings for the first time. New Down syndrome treatment suggested by Stanford/Packard study in mice At birth, children with Down syndrome aren't developmentally delayed. But as they age, these kids fall behind. Memory deficits inherent in Down syndrome hinder learning, making it hard for the brain to collect experiences needed for normal cognitive development. At-risk college students reduce HBP, anxiety, depression through Transcendental Meditation The Transcendental Meditation technique may be an effective method to reduce blood pressure, anxiety, depression, and anger among at-risk college students, according to a new study to be published in the American Journal of Hypertension, December 2009. Teens' mental health affects how long they stay in school, new study shows Queen's University researcher Steven Lehrer has won a prestigious international award in recognition of his contributions to health economics. Ethnic pride may boost African-American teens' mental health Most adolescents who belong to an ethnic minority group wrestle not only with their self-esteem (like most teens), but also with identity issues unique to their ethnic group, such as dealing with social stigma. A new study tells us that young people's ethnic pride may affect their mental health. Faulty body clock may make kids bipolar Malfunctioning circadian clock genes may be responsible for bipolar disorder in children. Researchers writing in the open access journal BMC Psychiatry found four versions of the regulatory gene RORB that were associated with pediatric bipolar disorder. Women with asthma feel worse Women with asthma are more anxious, find it harder to sleep and are more tired during the day than their male counterparts, but nevertheless tend to be better at following their treatment. Connection between depression and osteoporosis detailed by Hebrew University researchers Research carried out among thousands of people has shown a clear connection between depression and a loss of bone mass, leading to osteoporosis and fractures. More Depression Current Events and Depression News Articles |
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