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Alcohol increases rectal cancer risk, but risk is smaller among regular wine drinkers
May 09, 2003Regular drinkers significantly increase their risk of rectal cancer, but that risk is reduced if wine makes up a third or more of weekly consumption, suggests research in Gut.
The findings are based on a population study of over 29,000 Danish men and women aged between 23 and 95. Their weekly intake of beer, wine, and spirits was assessed, as were other factors likely to influence bowel cancer risk, such as how much they smoked, weighed, and took regular exercise.
Men were more likely than women to be heavy drinkers, and heavy drinkers were more likely to be smokers and to weigh more than light drinkers.
During a monitoring period of almost 15 years, 411 cases of colon cancer and 202 cases of rectal cancer were reported among those studied. Alcohol seemed to have little influence over the risk of colon cancer, but there was a clear association between rectal cancer risk and the amount of alcohol consumed. Those drinking more than 41 units of alcohol a week had twice the risk of developing the disease as non-drinkers.
But the type of alcohol consumed had a significant bearing on rectal cancer risk. Those who drank 14 or more units of beer or spirits a week were over 3.5 times as likely to develop rectal cancer as non-drinkers. Yet those who drank the same total amount of alcohol, but who included around a third or more of wine in their intake were less than twice as likely to develop the disease.
The authors point out that wine drinkers tended to be better educated and to take more exercise than beer or spirit drinkers, so there may be other healthier lifestyle factors at play.
There are no obvious reasons why alcohol should apparently be more damaging to the rectum than the colon, say the authors, but the reasons why wine seems to exert its protective effect most likely lie in resveratrol, which is found in both grapes and wine. Previous research indicates that this chemical damps down the cellular processes involved in the promotion and growth of cancerous cells.
British Medical Journal (BMJ)
During a monitoring period of almost 15 years, 411 cases of colon cancer and 202 cases of rectal cancer were reported among those studied. Alcohol seemed to have little influence over the risk of colon cancer, but there was a clear association between rectal cancer risk and the amount of alcohol consumed. Those drinking more than 41 units of alcohol a week had twice the risk of developing the disease as non-drinkers.
But the type of alcohol consumed had a significant bearing on rectal cancer risk. Those who drank 14 or more units of beer or spirits a week were over 3.5 times as likely to develop rectal cancer as non-drinkers. Yet those who drank the same total amount of alcohol, but who included around a third or more of wine in their intake were less than twice as likely to develop the disease.
The authors point out that wine drinkers tended to be better educated and to take more exercise than beer or spirit drinkers, so there may be other healthier lifestyle factors at play.
There are no obvious reasons why alcohol should apparently be more damaging to the rectum than the colon, say the authors, but the reasons why wine seems to exert its protective effect most likely lie in resveratrol, which is found in both grapes and wine. Previous research indicates that this chemical damps down the cellular processes involved in the promotion and growth of cancerous cells.
British Medical Journal (BMJ)
Colon Cancer Current Events and Colon Cancer News RSSOther Illnesses, Body Weight Do Not Explain Racial Disparities in Colon Cancer Survival, UAB Researchers Say
A new study by University of Alabama at Birmingham (UAB) researchers shows that body-mass index (BMI) and co-existing medical conditions (co-morbidity) do not explain the decreased survival observed among African-Americans compared to Caucasians who also have colon cancer.
Paradoxical protein might prevent cancer
One difficulty with fighting cancer cells is that they are similar in many respects to the body's stem cells. By focusing on the differences, researchers at Karolinska Institutet have found a new way of tackling colon cancer. The study is presented in the prestigious journal Cell.
Coffee break: Compound brewing new research in colon, breast cancer
A compound in coffee has been found to be estrogenic in studies by Texas AgriLife Research scientists.
Curry-cure? Spicing up the effectiveness of a potential disease-fighter
Scientists are reporting development of a nano-size capsule that boosts the body's uptake of curcumin, an ingredient in yellow curry now being evaluated in clinical trials for treatment of several diseases.
Colon cancer screening more effective earlier in day, UCLA study finds
The effectiveness of a screening colonoscopy may depend on the time of day it is performed. According to a new UCLA study, early-morning colonoscopies yielded more polyps per patient than later screenings, and fewer polyps were found hour by hour as the day progressed.
Study shows hormone replacement therapy decreases mortality in younger postmenopausal woman
Hormone replacement therapy (HRT) to treat menopausal estrogen deficiency has been in widespread use for over 60 years. Several observational studies over the years showed that HRT use by younger postmenopausal women was associated with a significant reduction in total mortality; available evidence supported the routine use of HRT to increase longevity in postmenopausal women.
Experts issue call to reconsider screening for breast cancer and prostate cancer
Twenty years of screening for breast and prostate cancer - the most diagnosed cancer for women and men - have not brought the anticipated decline in deaths from these diseases, argue experts from the University of California, San Francisco and the University of Texas Health Science Center at San Antonio in an opinion piece published in the "Journal of the American Medical Association."
Metals could forge new cancer drug
Drugs made using unusual metals could form an effective treatment against colon and ovarian cancer, including cancerous cells that have developed immunity to other drugs, according to research at the University of Warwick and the University of Leeds.
New data: Hospital imaging centers poised to pull back, hitting patients hardest in rural areas
Survivors and patients with cancers and heart disease, along with patient advocate organizations and physicians, today urged policymakers to enhance early diagnosis of deadly diseases by preserving access to advanced imaging, such as MRI and CT scans, in final health care reform legislation.
Whole-brain radiotherapy after surgery or radiosurgery not recommended for brain metastases
Whole-brain radiotherapy should not be given routinely to all patients whose cancer has spread to the brain, say researchers who found that using it after surgery or radiosurgery in patients with a limited number of brain metastases and stable cancer in the rest of the body did not extend lives or help patients remain functionally independent for longer.
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