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Newly Identified Gene Activated In 80% Of Breast Cancer Patients
April 25, 2003New research, published this week in Breast Cancer Research, could provide a genetic explanation for breast cancer. A George Washington University Medical Center team, led by Patricia Berg, has discovered that the gene BP1 is activated in 80% of breast cancer patients. The researchers believe that this gene may offer a useful new target for early breast cancer detection and therapy.
The results of the published study suggest that the gene may be active very early in cancer development, making screening for it potentially useful for early detection. Berg's team is now trying to develop a blood test for BP1.
Berg has been working with the gene for a number of years, and has previously found evidence of BP1 activity in other cancers - including a particular type of leukemia. Her previous research suggests that when the gene is switched on, it helps cancerous cells survive.
Breast cancer tissue from 46 patients was tested. The rate of expression or "activation" for Caucasian women with breast cancer was 57%. Among African American women, it was 89%. According to Berg, "While the research into BP1 may impact all groups with breast cancer in that there was an overall higher expression rate, the findings may prove especially helpful to African Americans, who disproportionately expressed the new gene." BP1 expression was found in only one of seven samples of normal
breast tissue.
Gene therapy targeting BP1 is also a possibility for the future. If a drug can be found which 'turns off' the gene, it could help people with non-hereditary breast cancer. Non-hereditary breast cancer accounts for 95% of cases, and it is in tumors of this type that the researchers found BP1 was active.
Berg points to more than 1.2 million people diagnosed with breast cancer annually and states, "We hope that this kind of research can make a real difference in addressing a major disease. Breast cancer is the leading cause of death among American women aged 33 to 55." She goes on to say that the discovery, cloning, and findings of the effect of the new gene "could now expedite research to put us further on the trail of treating breast cancer and other cancers."
BioMed Central Limited
Breast cancer tissue from 46 patients was tested. The rate of expression or "activation" for Caucasian women with breast cancer was 57%. Among African American women, it was 89%. According to Berg, "While the research into BP1 may impact all groups with breast cancer in that there was an overall higher expression rate, the findings may prove especially helpful to African Americans, who disproportionately expressed the new gene." BP1 expression was found in only one of seven samples of normal
breast tissue.
Gene therapy targeting BP1 is also a possibility for the future. If a drug can be found which 'turns off' the gene, it could help people with non-hereditary breast cancer. Non-hereditary breast cancer accounts for 95% of cases, and it is in tumors of this type that the researchers found BP1 was active.
Berg points to more than 1.2 million people diagnosed with breast cancer annually and states, "We hope that this kind of research can make a real difference in addressing a major disease. Breast cancer is the leading cause of death among American women aged 33 to 55." She goes on to say that the discovery, cloning, and findings of the effect of the new gene "could now expedite research to put us further on the trail of treating breast cancer and other cancers."
BioMed Central Limited
Breast Cancer Current Events and Breast Cancer News RSSResearchers Identify Role of Gene in Tumor Development, Growth and Progression
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Just as fly paper captures insects, an innovative new device with nano-sized features developed by researchers at UCLA is able to grab cancer cells in the blood that have broken off from a tumor.
Fertility procedures need not delay breast cancer treatment for younger women
A new study published in the November issue of the Journal of the American College of Surgeons shows that breast cancer patients under 40 years old who undergo fertility preservation do not face a significant delay in the treatment of their disease when their care is coordinated in a timely fashion.
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Drugs to treat anemia in cancer patients linked to thromboembolism
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Discovery in worms by Queen's researchers points to more targeted cancer treatment
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FDA approved leukemia drugs shows promise in ovarian cancer cells
The drug Sprycel, approved for use by the U.S. Food and Drug Administration in patients with chronic myeloid leukemia, significantly inhibited the growth and invasiveness of ovarian cancer cells and also promoted their death, a study by researchers with UCLA's Jonsson Comprehensive Cancer Center found.
Carnegie Mellon researchers link health-care debate to risk of dying in US and Europe
The current health care debate in the United States is complicated. Trade-offs between heath care expenditures, lifestyle choices and life expectancy have been suggested but seldom clearly demonstrated.
Scientists uncover new key to the puzzle of hormone therapy and breast cancer
The use of postmenopausal hormone therapy has decreased over time in the United States, which researchers suggest may play a key role in the declining rate of atypical ductal hyperplasia, a known risk factor for breast cancer.
Breast density associated with increased risk of cancer recurrence
A new study finds that women treated for breast cancer are at higher risk of cancer recurrence if they have dense breasts. Published in the December 15, 2009 issue of Cancer, a peer-reviewed journal of the American Cancer Society, the study's results indicate that breast cancer patients with dense breasts may benefit from additional therapies following surgery, such as radiation.
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