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WHAT FUTURE FOR CANNABIS?
April 16, 2003The potential therapeutic effects of cannabis are outlined in a review in the May issue of THE LANCET NEUROLOGY. The review is published in anticipation of results from randomised trials expected later this year investigating possible benefits of the drug for people with multiple sclerosis. The first cannabis-based medicines are currently being considered for license.
Cannabis is the third most popular recreational drug after alcohol and tobacco. The history, biological/pharmacological effects, and current research investigating its potential therapeutic benefits are outlined by Alan Thompson and David Baker from the Institute of Neurology, London, UK, and colleagues. They comment how-in addition to the research into multiple sclerosis-basic research is enabling the discovery that some cannabis compounds have previously unknown qualities-notably that cannabis could play a role in preventing neurodegeneration with implications for the future management of disorders such as Huntington's, Parkinson's, Alzheimer's, and motor-neuron diseases
Alan Thompson concludes: "As we learn more about the pharmacological activities of compounds in cannabis and their biological targets outside the cannabinoid system, varieties of cannabis might be tailored to different diseases or used in combination with known drugs. Whatever the future holds, there are many challenges to be overcome before we view cannabinoids as routine medicine in neurological disorders."
Lancet
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Memory loss linked to common sleep disorder
For the first time, UCLA researchers have discovered that people with sleep apnea show tissue loss in brain regions that help store memory.
Strong associations between disturbed rest/activity rhythms and mortality rates in older men
A research abstract that will be presented on Wednesday at SLEEP 2008, the 22nd Annual Meeting of the Associated Professional Sleep Societies (APSS), is the first to report strong associations between disturbed rest/activity rhythms and mortality rates in older, community-dwelling (non-institutionalized) men.
Hopkins researchers discover new link to schizophrenia
Neuroscientists at Johns Hopkins have discovered that mice lacking an enzyme that contributes to Alzheimer disease exhibit a number of schizophrenia-like behaviors.
A significant difference in the sleep disturbances among Alzheimer patients, caregivers
A study published in the May 1 issue of the journal SLEEP finds that sleep disturbances among Alzheimer patients vary significantly from those of their family caregivers, and that, surprisingly, poor sleep in either the patient or caregiver is not necessarily linked to disturbed sleep in the other.
Alzheimer's vaccine clears plaque but has little effect on learning and memory impairment
A promising vaccine being tested for Alzheimer's disease does what it is designed to do - clear beta-amyloid plaques from the brain - but it does not seem to help restore lost learning and memory abilities, according to a University of California, Irvine study.
Why fish oil is good for you
It's good news that we are living longer, but bad news that the longer we live, the better our odds of developing late-onset Alzheimer's disease.
Refuted claims from observational studies often persist despite strong evidence against them
Prominent claims from observational studies of the cardiovascular benefits of vitamin E often continue to be supported in medical literature despite strong contradictory evidence from randomized trials.
Dementia screening in primary care: Is it time?
Primary care physicians should focus on "dementia red flags" rather than routinely screen individuals with no dementia symptoms just because they've reached a certain age.
Drugs may not delay onset of dementia; and more
Researchers have examined the evidence in favour of giving people considered to be close to developing dementia the drugs that are most commonly used to treat the condition itself.
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