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Protein deficit impedes recovery after percutaneous angioplasty
January 24, 2003If the body contains too little of the protein haptoglobin, the recovery of the blood vessels after percutaneous angioplasty is impeded. The Utrecht researcher Mirjam Smeets suspects that this is one of the reasons why 40 percent of patients who have undergone percutaneous angioplasty experience a new constriction.
After percutaneous angioplasty, in which occluded vessels are stretched open with a small balloon, 40 percent of patients are rehospitalised with a new constriction of the same vessel. In order to develop drugs against this new vessel constriction, Smeets investigated the processes which occur during the constriction of the vessel wall.
Smeets discovered that the protein haptoglobin inhibits certain enzymes involved in the breakdown of collagen. Collagen is the substance which stiffens the vessel walls. If after percutaneous angioplasty the vessel wall becomes constricted again, there is an increased production and breakdown of collagen.
Moreover, the medical researcher discovered that haptoglobin is produced locally, i.e. in the vessel wall. It was already known that the liver (thus not locally) produces this protein on a large scale and secretes it into the blood.
Furthermore, in cell cultures it has been demonstrated that haptoglobin plays an important role in the migration of cells. Cells which do not produce the protein, migrate less easily. The addition of haptoglobin to these cells enables them to migrate more easily, which results in an improved recovery of damaged blood vessels.
Damaged arteries from mice which cannot produce haptoglobin, recover less well than those from mice which can. Meanwhile a follow-up study has demonstrated that people who cannot produce haptoglobin do not have an increased risk for arteriosclerosis or the occlusion of blood vessels following percutaneous angioplasty.
Knowledge acquired about the mechanism by which damaged blood vessels recover, should eventually lead to the development of drugs that prevent 40 percent of patients from being rehospitalised with a constriction of the same blood vessel following percutaneous angioplasty.
The research was funded by the Netherlands Organisation for Scientific Research (NWO).
NWO (Netherlands Organization for Scientific Research)
Moreover, the medical researcher discovered that haptoglobin is produced locally, i.e. in the vessel wall. It was already known that the liver (thus not locally) produces this protein on a large scale and secretes it into the blood.
Furthermore, in cell cultures it has been demonstrated that haptoglobin plays an important role in the migration of cells. Cells which do not produce the protein, migrate less easily. The addition of haptoglobin to these cells enables them to migrate more easily, which results in an improved recovery of damaged blood vessels.
Damaged arteries from mice which cannot produce haptoglobin, recover less well than those from mice which can. Meanwhile a follow-up study has demonstrated that people who cannot produce haptoglobin do not have an increased risk for arteriosclerosis or the occlusion of blood vessels following percutaneous angioplasty.
Knowledge acquired about the mechanism by which damaged blood vessels recover, should eventually lead to the development of drugs that prevent 40 percent of patients from being rehospitalised with a constriction of the same blood vessel following percutaneous angioplasty.
The research was funded by the Netherlands Organisation for Scientific Research (NWO).
NWO (Netherlands Organization for Scientific Research)
Angioplasty Current Events and Angioplasty News RSSYour Own Stem Cells Can Treat Heart Disease
The largest national stem cell study for heart disease showed the first evidence that transplanting a potent form of adult stem cells into the heart muscle of subjects with severe angina results in less pain and an improved ability to walk. The transplant subjects also experienced fewer deaths than those who didn't receive stem cells.
Vitamin B niacin offers no extra benefit to statin therapy in seniors already diagnosed with CAD
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Study questions need for routine intervention in patients with renovascular disease
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Designing drugs and their antidotes together improves patient care
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Pre-hospital organization: The first links in the chain of survival for heart attack patients
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Stent for life initiative
Primary angioplasty (with stent implantation) is the most effective therapy for acute myocardial infarction (AMI), but it is not available to many patients, even though most European countries have sufficient resources (ie, catheterisation laboratories) for its wider use.
Otamixaban for the treatment of patients with non-ST-elevation acute coronary syndromes
Data from a phase II trial of an investigational intravenous drug designed to block the formation of blood clots shows potential to reduce the risk of death, a second heart attack, or other coronary complications compared with the current standard of care in patients presenting with acute coronary syndromes (heart attacks or unstable angina).
New strategies for reperfusion therapy
A new trial has begun in order to ascertain once and for all whether the best strategy for patients who cannot receive P-PCI is early fibrinolysis, together with mandated angiography.
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