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Light shed on vision and hearing disorders
December 16, 2002The most common hereditary condition that affects both hearing and vision is Usher Syndrome (USH). In the next issue of The EMBO Journal, scientists at the Institut Pasteur report on studies that have established the first link between Myosin VIIa, Cadherin 23 and Harmonin b. These three proteins were previously known to be involved in the disease, but mutations in them had only been found in separate groups of patients. In this report, the team of Christine Petit demonstrates that these proteins function together to shape and maintain highly specialized structures at the tips of the sensory cells of the inner ear. It is precisely these structures that are essential for hearing, but which are defective in patients with Usher Syndrome.
For full article (PDF) contact: Ellen.Peerenboom@embo.org
European Molecular Biology Organization (EMBO)
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