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Organic & Biomolecular Chemistry

December 05, 2002

First Advance Articles Now Available Free Online

The first issue of Organic & Biomolecular Chemistry, formed from the merger and strategic development of Perkin Transactions 1 & 2, will be published on 10 January 2003. The electronic version will go up on 23 December 2002.

Barbara Imperiali, Francois Diederich, Ben Feringa and Chi-Huey Wong are amongst the first eminent scientists to publish Advance Articles in the journal. Further details are given below. The first issue will also feature contributions from Steve Ley, Jay Siegel and
Michael Burkart, these will be available online soon.

Advance Articles Now Available on the Journal Website Include:-

PERSPECTIVE
-        HIV-1 Protease: Mechanism and Drug Discovery
-        Chi-Huey Wong, Scripps, USA

COMMUNICATIONS
-        A donor-acceptor substituted molecular motor: unidirectional rotation driven by visible light.
-        Ben Feringa, Groningen, The Netherlands

-        A new synthesis of porphobilinogen analogues, inhibitors of hydroxymethylbilane synthase
-        Finian Leeper, Cambridge, UK

-        Non-steady-state kinetic study of the SN2 reaction between p-nitrophenoxide ion and methyl iodide in aprotic solvents containing water. Evidence for a 2-step mechanism.
-        Vernon D. Parker, Utah State, USA

-        Facilitated transport of sodium or potassium chloride across vesicle membranes using a ditopic salt-binding macrobicycle
-        Bradley D. Smith, Notre Dame, USA

-        From central to planar chirality, the first example of atropenantioselective cycloetherification
-        Jieping Zhu, CNRS, France

ARTICLES
-        Bisubstrate inhibitors for the enzyme catechol-O-methyltransferase (COMT): influence of inhibitor preorganisation and linker length between the two substrate moieties on binding affinity
-        Fran'§ois Diederich, ETH, Switzerland

-        Peptides to peptidomimetics: Towards the design and synthesis of bioavailable inhibitors of oligosaccharyl transferase
-        Barbara Imperiali, MIT, USA

-        Synthesis of novel chiral phosphinocyrhetrenyloxazoline ligands and their application in asymmetric catalysis
-        Carsten Bolm, Aachen, Germany

-        Transformations of cyclic nonaketides by Aspergillus terreus mutants blocked for lovastatin biosynthesis at the lovA and lovC genes
-        John Vederas, Alberta, Canada

Organic & Biomolecular Chemistry will be an essential read for organic chemists. The new journal has attracted contributions from a great number of leading institutions all over the world on topics covering the full breadth of organic chemistry.

These are exciting times for organic chemists, who are at the molecular heart of life science. Synthetic and physical organic chemistry are rapidly gaining importance in the emerging fields of chemical biology and nanotechnology where they play a crucial role in the development of new bioactive substances and novel materials. Organic & Biomolecular Chemistry will be key to the dissemination of these advances.

www.rsc.org/obc

Royal Society of Chemistry (RSC)