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Researchers make a significant advance in treating asthma
December 02, 2002The findings of this research published on 30th November 2002 in The Lancet suggest that targeting the underlying cause of asthma-rather than treating symptoms of the disorder-could be more effective in reducing severe asthma attacks.
Asthma affects 5.1 million people in the UK and leads to an estimated 1,500 deaths per year, however current treatment methods, based on an assessment of symptoms and a measurement of lung function may not be the most effective.
Asthma is known to be associated with increased numbers of microscopic cells called eosinophils, in the airway. These can be detected by a simple sputum test and their numbers rise several weeks before an asthma attack. A groundbreaking study undertaken by Institute for Lung Health researchers Dr Ian Pavord and Dr Ruth Green assessed whether treatment which aimed to reduce the number of eosinophils reduced severe asthma attacks compared with conventional treatment.
A study of 74 patients with moderate to severe asthma were randomly placed into two groups. One was treated conventionally, the other using the sputum test with their medication regulated in response to changes in eosinophil numbers.
The results showed that the sputum test group had fewer severe attacks and hospitalisations than the conventional treatment group.
Dr Pavord comments 'severe asthma attacks that require treatment with steroids or hospital admission are the most serious manifestation of the disease. They lead to asthma deaths, illness and a high cost to the health service in terms of doctor consultations, drug use and hospital beds. This approach of maintaining a normal eosinophil count resulted in a large reduction in the number of severe attacks compared with conventional management methods.'
This study which will be presented by Dr Ruth Green next week at the British Thoracic Society meeting in London as part of the National Young Investigators Award, has major implications in that it allows treatment to be targeted more precisely at those who require it most, thereby reducing demand on resources.
This study also has implications for the future of asthma research as it provides further evidence that the mechanisms that cause mild asthma symptoms are different to those that underlie a severe attack.
This is the latest in a series of important discoveries made by members of Leicester's Institute for Lung Health. Discoveries that put the Institute at the forefront of research into adult and childhood lung disease.
Institute for Lung Health
Asthma Current Events and Asthma News RSSStudy strengthens link between tobacco smoke and behavioral problems in boys with asthma
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Pregnant women with asthma can be more confident about some medicines
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Study shows school-based program enables children and adolescents to better manage chronic disease
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Pregnant women with asthma can be more confident about some medicines
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Fall babies: Born to wheeze?
It is said that timing is everything, and that certainly appears to be true for autumn infants. Children who are born four months before the height of cold and flu season have a greater risk of developing childhood asthma than children born at any other time of year, according to new research.
Hospital visits for respiratory illnesses spiked during Southern California wildfires
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The miseries of allergies just may help prevent some cancers, study finds
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Is ineffective esophageal motility associated with gastropharyngeal reflux disease?
IEM is associated with an increased acid clearance times in the distal esophagus. Gastropharyngeal reflux causes supraesophageal manifestations such as globus, chronic cough, hoarseness, asthma, chronic sinusitis, or other otorhinolaryngologic diseases.
Flu vaccination rates lag for at-risk adolescents
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Tweens and teens double use of diabetes drugs
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