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Researchers make a significant advance in treating asthma
December 02, 2002The findings of this research published on 30th November 2002 in The Lancet suggest that targeting the underlying cause of asthma-rather than treating symptoms of the disorder-could be more effective in reducing severe asthma attacks.
Asthma affects 5.1 million people in the UK and leads to an estimated 1,500 deaths per year, however current treatment methods, based on an assessment of symptoms and a measurement of lung function may not be the most effective.
Asthma is known to be associated with increased numbers of microscopic cells called eosinophils, in the airway. These can be detected by a simple sputum test and their numbers rise several weeks before an asthma attack. A groundbreaking study undertaken by Institute for Lung Health researchers Dr Ian Pavord and Dr Ruth Green assessed whether treatment which aimed to reduce the number of eosinophils reduced severe asthma attacks compared with conventional treatment.
A study of 74 patients with moderate to severe asthma were randomly placed into two groups. One was treated conventionally, the other using the sputum test with their medication regulated in response to changes in eosinophil numbers.
The results showed that the sputum test group had fewer severe attacks and hospitalisations than the conventional treatment group.
Dr Pavord comments 'severe asthma attacks that require treatment with steroids or hospital admission are the most serious manifestation of the disease. They lead to asthma deaths, illness and a high cost to the health service in terms of doctor consultations, drug use and hospital beds. This approach of maintaining a normal eosinophil count resulted in a large reduction in the number of severe attacks compared with conventional management methods.'
This study which will be presented by Dr Ruth Green next week at the British Thoracic Society meeting in London as part of the National Young Investigators Award, has major implications in that it allows treatment to be targeted more precisely at those who require it most, thereby reducing demand on resources.
This study also has implications for the future of asthma research as it provides further evidence that the mechanisms that cause mild asthma symptoms are different to those that underlie a severe attack.
This is the latest in a series of important discoveries made by members of Leicester's Institute for Lung Health. Discoveries that put the Institute at the forefront of research into adult and childhood lung disease.
Institute for Lung Health
A study of 74 patients with moderate to severe asthma were randomly placed into two groups. One was treated conventionally, the other using the sputum test with their medication regulated in response to changes in eosinophil numbers.
The results showed that the sputum test group had fewer severe attacks and hospitalisations than the conventional treatment group.
Dr Pavord comments 'severe asthma attacks that require treatment with steroids or hospital admission are the most serious manifestation of the disease. They lead to asthma deaths, illness and a high cost to the health service in terms of doctor consultations, drug use and hospital beds. This approach of maintaining a normal eosinophil count resulted in a large reduction in the number of severe attacks compared with conventional management methods.'
This study which will be presented by Dr Ruth Green next week at the British Thoracic Society meeting in London as part of the National Young Investigators Award, has major implications in that it allows treatment to be targeted more precisely at those who require it most, thereby reducing demand on resources.
This study also has implications for the future of asthma research as it provides further evidence that the mechanisms that cause mild asthma symptoms are different to those that underlie a severe attack.
This is the latest in a series of important discoveries made by members of Leicester's Institute for Lung Health. Discoveries that put the Institute at the forefront of research into adult and childhood lung disease.
Institute for Lung Health
Asthma Current Events and Asthma News RSSExposures to metals and diesel emissions in air linked to respiratory symptoms in children
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New research presents strong evidence that the "synergistic" effect of early-life exposure to both outdoor traffic-related pollution and indoor endotoxin causes more harm to developing lungs than one or the other exposure alone.
Johns Hopkins researchers track down protein responsible for chronic rhinosinusitis with polyps
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Ancestry attracts, but love is blind
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Common plastics chemicals linked to ADHD symptoms
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Asthma a significant risk factor for complications in children with H1N1
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Mother's Depression a Risk Factor in Childhood Asthma Symptoms, Study Suggests
Asthma symptoms can worsen in children with depressed mothers, according to research from Johns Hopkins Children's Center published online in the Journal of Pediatric Psychology.
Sweet -- sugared polymer a new weapon against allergies and asthma
Scientists at Johns Hopkins and their colleagues have developed sugar-coated polymer strands that selectively kill off cells involved in triggering aggressive allergy and asthma attacks.
Pivotal study for PSD502 -- the first potential treatment for premature ejaculation
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Aileron collaborates study in Nature: Stapled peptides inhibit Notch1 transcription factor
This research validates the potential for Stapled Peptides to modulate key intracellular biological targets, such as transcription factors, that have not been addressable with current small molecule or biologic drug modalities.
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