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Initial type and frequency of migraine influences women’s stroke risk
November 18, 2002The risk of ischaemic stroke is significantly increased in women whose first ever migraines were accompanied by aura, finds research in the Journal of Neurology, Neurosurgery and Psychiatry.
Ischaemic strokes are caused by a blockage to the arterial blood supply rather than a burst, which characterises a subarachnoid or haemorrhagic stroke.
The authors based their findings on further analysis of 300 women aged 20 to 44, who had taken part in a larger World Health Organisation Collaborative Study of Cardiovascular Disease and Steroid Hormone Contraception. Between 1990 and 1993, they compared 86 women admitted to hospital with a first time ischaemic stroke with 214 women admitted to hospital for other illness.
Compared with the other women, the risk of ischaemic stroke increased by a factor of 8 in those whose first ever migraines were accompanied by aura, and by a factor of 10 in those whose first migraines with aura occurred more than once a month. Stroke risk was four times higher in those whose migraine attacks had gone on for more than 12 years.
Use of oral contraceptives is known to slightly increase the overall risk of stroke in women with migraine, say the authors, but there was no evidence in this study that oral contraceptives specifically influenced the particular risks associated with the initial type and frequency of migraine.
The authors point to other research, which estimates the lifetime prevalence of migraine to be in the region of 25 to 33%, only a proportion of which will be migraine with aura. Overall, migraine triples the risk of stroke, although the authors hasten to point out that the absolute risk is small: 15 per 100,000 woman years.
They conclude that initial migraine type may be important in determining the eventual risk of stroke.
British Medical Journal (BMJ)
Compared with the other women, the risk of ischaemic stroke increased by a factor of 8 in those whose first ever migraines were accompanied by aura, and by a factor of 10 in those whose first migraines with aura occurred more than once a month. Stroke risk was four times higher in those whose migraine attacks had gone on for more than 12 years.
Use of oral contraceptives is known to slightly increase the overall risk of stroke in women with migraine, say the authors, but there was no evidence in this study that oral contraceptives specifically influenced the particular risks associated with the initial type and frequency of migraine.
The authors point to other research, which estimates the lifetime prevalence of migraine to be in the region of 25 to 33%, only a proportion of which will be migraine with aura. Overall, migraine triples the risk of stroke, although the authors hasten to point out that the absolute risk is small: 15 per 100,000 woman years.
They conclude that initial migraine type may be important in determining the eventual risk of stroke.
British Medical Journal (BMJ)
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