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Inhibitor of novel cancer target, LPAAT-beta, demonstrates selective anti-cancer effects in animal cancer models
November 17, 2002Frankfurt, Germany: In a plenary session at the Symposium on Molecular Targets and Cancer Therapeutics, Dr Jack W. Singer, M.D. and Research Program Chairman of Cell Therapeutics, Inc. (CTI) today (Thursday 21 November) presented data from preclinical studies on a novel cancer target LPAAT-beta[1] in cultured cells and in preliminary animal models.
Through preclinical studies, CTI scientists found that LPAAT-beta is highly expressed in cancers of the lung, ovary, prostate, bladder, cervix and brain but is minimally expressed in most normal tissues. When LPAAT-b was over expressed in cell lines, they became more tumorigenic and this change was reversed when the over-expressed gene was removed. When LPAATb expression was decreased in tumor cells by a genetic technique known as RNAi, their proliferation decreased. CTI scientists also developed small molecule inhibitors specific to LPAAT-b and these compounds induce apoptosis (cell death) in a wide variety of tumor cell lines. When nude mice bearing HT-29 colon cancer were treated with the compound, it delayed tumor growth significantly without producing toxicities. Similar results were achieved with related compounds in mice with Lewis lung cancers or NCI-H460 human lung cancers.
"These data affirm what we had previously noted in our initial studies ? that the enzyme LPAAT-b produces a cofactor for signalling pathways that may be essential to cancer cell growth and viability and the inhibition of this enzyme causes cancer cells to die," Dr Singer told a news briefing today (Thursday 21 November) at the EORTC-NCI-AACR[2] Symposium on Molecular Targets and Cancer Therapeutics.
He added: "The experiments in animal models show that the small molecule LPAAT-b inhibitors can effectively kill tumor cells without having pronounced effects on normal cells."
MW Communications
He added: "The experiments in animal models show that the small molecule LPAAT-b inhibitors can effectively kill tumor cells without having pronounced effects on normal cells."
MW Communications
Cancer Current Events and Cancer News RSSMenopause-cardiology consensus statement on cardiovascular disease and on HRT
A menopause-cardiology consensus statement has called for direct action to prevent cardiovascular disease (CVD) in menopausal women. The statement also concludes that there is little evidence of increased CVD risk in taking HRT.
Other Illnesses, Body Weight Do Not Explain Racial Disparities in Colon Cancer Survival, UAB Researchers Say
A new study by University of Alabama at Birmingham (UAB) researchers shows that body-mass index (BMI) and co-existing medical conditions (co-morbidity) do not explain the decreased survival observed among African-Americans compared to Caucasians who also have colon cancer.
Multiple health concerns surface as winter, vitamin D deficiences arrive
A string of recent discoveries about the multiple health benefits of vitamin D has renewed interest in this multi-purpose nutrient, increased awareness of the huge numbers of people who are deficient in it, spurred research and even led to an appreciation of it as "nature's antibiotic."
AIDS research reveals a lack of family-planning programs in Uganda
University of Alberta graduate student Jennifer Heys wants to make her message clear: there needs to be more education in Ugandan communities about contraception.
Possible Link Studied Between Childhood Abuse and Early Cellular Aging
Children who suffer physical or emotional abuse may be faced with accelerated cellular aging as adults, according to new research from Butler Hospital and Brown University.
Rare pancreatic cancer patients may live longer when treated with radiation therapy
Radiation therapy is effective in achieving local control and palliation in patients with pancreatic neuroendocrine tumors (PNTs), despite such tumors being commonly considered resistant to radiation therapy.
Researchers Identify Role of Gene in Tumor Development, Growth and Progression
Virginia Commonwealth University Massey Cancer Center and VCU Institute of Molecular Medicine researchers have identified a gene that may play a pivotal role in two processes that are essential for tumor development, growth and progression to metastasis.
Saving the single cysteine: new antioxidant system found
We've all read studies about the health benefits of having a life partner. The same thing is true at the molecular level, where amino acids known as cysteines are much more vulnerable to damage when single than when paired up with other cysteines.
Gene mismatch influences success of bone marrow transplants
A commonly inherited gene deletion can increase the likelihood of immune complications following bone marrow transplantation, an international team of researchers reports in the November 22 advance online issue of Nature Genetics.
Cancer metabolism discovery uncovers new role of IDH1 gene mutation in brain cancer
Agios Pharmaceuticals today announced that its scientists have established, for the first time, that the mutated IDH1 gene has a novel enzyme activity consistent with a cancer-causing gene, or oncogene.
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