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Xerion Pharmaceuticals and Arius Research sign colon cancer collaboration
October 15, 2002Martinsried, Germany and Cambridge, Massachusetts, USA - October 15, 2002Xerion Pharmaceuticals and ARIUS Research Inc. of Canada announced today that they would combine their respective strengths in functional proteomics and antibody discovery to jointly develop products for cancer therapy. Xerion will take four antibodies from ARIUS' functional antibody library and apply its Xstream™ process to evaluate their therapeutic potential in cancer. Under the terms of the agreement, the two companies will share revenues from out-licensed targets, co-develop the targets or pay the other party for an exclusive license to the targets.
The agreement follows Xerion's recent target characterization and drug discovery research collaboration with Cambridge Antibody Technology plc to investigate new mechanisms of intervention in allergic disease.
Xerion's core technology has been used to functionally validate more than fifty proteins in a disease-relevant biological context. ARIUS contributes functional antibodies generated through its proprietary discovery process. ARIUS has already shown that antibodies in its library can have dramatic anti-cancer properties. Examples include ARVitamab®, which shows anti-metastatic effects in an aggressive model of human lung cancer in addition to controlling tumour size, and two anti-breast cancer antibodies, ARH460-16-2, and ARH460-22-1, which produce almost complete tumour suppression in a model of human breast cancer.
"Working in collaboration with ARIUS, we expect to identify high quality novel targets and increase our pipeline of validated targets. This relationship provides us with an additional pathway for developing more therapeutic antibody leads," said Dr. Markus Ewert, President and CEO of Xerion. "Xerion is focused on rapidly turning its discovery efforts into generating viable therapeutic antibodies. We have internally generated therapeutic antibodies against cancer targets for which we intend to initiate pre-clinical studies next year. We look forward to working with ARIUS and to both parties expanding their therapeutic antibody development pipeline in treating cancer."
Commenting on the collaboration ARIUS` President and Chief Scientific Officer, Dr. David Young, said: "We are very pleased to be working with Xerion. A target's value can be significantly enhanced by understanding its overall role in disease and Xerion's core strength in target validation will be instrumental in maximizing this value. This deal signals to the investment community that we are meeting our business objectives and executing our business plan. Our efficiency in producing functional antibodies gives us the unique ability to enter into partnerships on multiple fronts for expertise and other resources that complement our set of strengths to rapidly increase the value of our antibody and technologies and meet our financial objectives".
Charles Consultants
Commenting on the collaboration ARIUS` President and Chief Scientific Officer, Dr. David Young, said: "We are very pleased to be working with Xerion. A target's value can be significantly enhanced by understanding its overall role in disease and Xerion's core strength in target validation will be instrumental in maximizing this value. This deal signals to the investment community that we are meeting our business objectives and executing our business plan. Our efficiency in producing functional antibodies gives us the unique ability to enter into partnerships on multiple fronts for expertise and other resources that complement our set of strengths to rapidly increase the value of our antibody and technologies and meet our financial objectives".
Charles Consultants
Cancer Current Events and Cancer News RSSMenopause-cardiology consensus statement on cardiovascular disease and on HRT
A menopause-cardiology consensus statement has called for direct action to prevent cardiovascular disease (CVD) in menopausal women. The statement also concludes that there is little evidence of increased CVD risk in taking HRT.
Other Illnesses, Body Weight Do Not Explain Racial Disparities in Colon Cancer Survival, UAB Researchers Say
A new study by University of Alabama at Birmingham (UAB) researchers shows that body-mass index (BMI) and co-existing medical conditions (co-morbidity) do not explain the decreased survival observed among African-Americans compared to Caucasians who also have colon cancer.
Multiple health concerns surface as winter, vitamin D deficiences arrive
A string of recent discoveries about the multiple health benefits of vitamin D has renewed interest in this multi-purpose nutrient, increased awareness of the huge numbers of people who are deficient in it, spurred research and even led to an appreciation of it as "nature's antibiotic."
AIDS research reveals a lack of family-planning programs in Uganda
University of Alberta graduate student Jennifer Heys wants to make her message clear: there needs to be more education in Ugandan communities about contraception.
Possible Link Studied Between Childhood Abuse and Early Cellular Aging
Children who suffer physical or emotional abuse may be faced with accelerated cellular aging as adults, according to new research from Butler Hospital and Brown University.
Rare pancreatic cancer patients may live longer when treated with radiation therapy
Radiation therapy is effective in achieving local control and palliation in patients with pancreatic neuroendocrine tumors (PNTs), despite such tumors being commonly considered resistant to radiation therapy.
Researchers Identify Role of Gene in Tumor Development, Growth and Progression
Virginia Commonwealth University Massey Cancer Center and VCU Institute of Molecular Medicine researchers have identified a gene that may play a pivotal role in two processes that are essential for tumor development, growth and progression to metastasis.
Saving the single cysteine: new antioxidant system found
We've all read studies about the health benefits of having a life partner. The same thing is true at the molecular level, where amino acids known as cysteines are much more vulnerable to damage when single than when paired up with other cysteines.
Gene mismatch influences success of bone marrow transplants
A commonly inherited gene deletion can increase the likelihood of immune complications following bone marrow transplantation, an international team of researchers reports in the November 22 advance online issue of Nature Genetics.
Cancer metabolism discovery uncovers new role of IDH1 gene mutation in brain cancer
Agios Pharmaceuticals today announced that its scientists have established, for the first time, that the mutated IDH1 gene has a novel enzyme activity consistent with a cancer-causing gene, or oncogene.
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