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The Lancet Oncology
October 02, 2002CLEAR SKIES NOT SO CLEAN
This months Leading Edge editorial examines the recently published US Environmental Protection Agency`s (EPA) 10-year in-the-making report on the toxic effects of diesel exhaust fumes from large vehicles. The report-which showed that large cities are heavily polluted with emissions that are associated with increased risk of lung cancer-has clear public-health implications for a political administration that does not appear to giving a high priority to environmental issues.
The editorial comments: 'The development of effective environmental policies should be a priority for all governments. Healthcare professionals are in great need of solid evidence-based policies rather than legislation based on economic or qualitative criteria. When a report with the strength of the EPA study presents persuasive quantitative evidence, the benefits of any resultant policies should be patently obvious and viewed as an integral part of healthcare provision, rather than isolated environmental issues.'
HORMONAL RISK FACTORS FOR BREAST CANCER - IDENTIFICATION, CHEMOPREVENTION, AND OTHER PREVENTION STRATEGIES
Breast cancer is a leading cause of female illness and death worldwide. Many hormonal and genetic risk factors have been identified and have led to the development of mathematical models that can be used in the clinic to give a woman an estimate of her individual risk of developing breast cancer. These models can also be used to identify women who might benefit from breast-cancer chemoprevention with tamoxifen or be suitable for entry into trials with new agents. This review article discusses two mathematical models (the Gale model and the Clause model) and their relative strengths in identifying a woman's breast-cancer risk. The Claus model is based mainly on family history, whereas the Gail model also includes simple markers of oestrogen exposure. The authors also explore more sophisticated measures of lifetime oestrogen exposure that can be used to improve the discriminatory ability of these models; they also appraise the four trials of breast-cancer chemoprevention, including the trial that led to the licensing of tamoxifen in the USA. The review concludes with a discussion other agents and interventions that could be used in the future to improve the efficacy and tolerability of breast-cancer risk reduction.
OTHER REVIEWS:
Neoadjuvant and adjuvant therapy for resectable hepatocellular carcinoma: review of the randomised clinical trials
Dynamism of tumour vasculature in the early phase of cancer progression: outcomes from oesophageal cancer research
Informing and involving cancer patients in their own care.
Quality of life in patients undergoing systemic therapy for advanced breast cancer.
Beyond futility: to what extend is the concept of futility used in clinical decision-making about CPR?
Lancet
HORMONAL RISK FACTORS FOR BREAST CANCER - IDENTIFICATION, CHEMOPREVENTION, AND OTHER PREVENTION STRATEGIES
Breast cancer is a leading cause of female illness and death worldwide. Many hormonal and genetic risk factors have been identified and have led to the development of mathematical models that can be used in the clinic to give a woman an estimate of her individual risk of developing breast cancer. These models can also be used to identify women who might benefit from breast-cancer chemoprevention with tamoxifen or be suitable for entry into trials with new agents. This review article discusses two mathematical models (the Gale model and the Clause model) and their relative strengths in identifying a woman's breast-cancer risk. The Claus model is based mainly on family history, whereas the Gail model also includes simple markers of oestrogen exposure. The authors also explore more sophisticated measures of lifetime oestrogen exposure that can be used to improve the discriminatory ability of these models; they also appraise the four trials of breast-cancer chemoprevention, including the trial that led to the licensing of tamoxifen in the USA. The review concludes with a discussion other agents and interventions that could be used in the future to improve the efficacy and tolerability of breast-cancer risk reduction.
OTHER REVIEWS:
Neoadjuvant and adjuvant therapy for resectable hepatocellular carcinoma: review of the randomised clinical trials
Dynamism of tumour vasculature in the early phase of cancer progression: outcomes from oesophageal cancer research
Informing and involving cancer patients in their own care.
Quality of life in patients undergoing systemic therapy for advanced breast cancer.
Beyond futility: to what extend is the concept of futility used in clinical decision-making about CPR?
Lancet
Estrogen Current Events and Estrogen News RSSMenopause-cardiology consensus statement on cardiovascular disease and on HRT
A menopause-cardiology consensus statement has called for direct action to prevent cardiovascular disease (CVD) in menopausal women. The statement also concludes that there is little evidence of increased CVD risk in taking HRT.
Heart and bone damage from low vitamin D tied to declines in sex hormones
Researchers at Johns Hopkins are reporting what is believed to be the first conclusive evidence in men that the long-term ill effects of vitamin D deficiency are amplified by lower levels of the key sex hormone estrogen, but not testosterone.
Fertility procedures need not delay breast cancer treatment for younger women
A new study published in the November issue of the Journal of the American College of Surgeons shows that breast cancer patients under 40 years old who undergo fertility preservation do not face a significant delay in the treatment of their disease when their care is coordinated in a timely fashion.
Coffee break: Compound brewing new research in colon, breast cancer
A compound in coffee has been found to be estrogenic in studies by Texas AgriLife Research scientists.
Mayo researchers find robotic repair for vaginal prolapse has significant benefits
New Mayo Clinic research has found that robotic surgery for vaginal prolapse dramatically reduces patient hospital stay and recovery time.
Estrogen therapy likely must be given soon after menopause to provide stroke protection
For estrogen replacement to provide stroke protection, it likely must be given soon after levels drop because of menopause or surgical removal of the ovaries, scientists report in the Journal of Neuroscience.
Oral contraceptives may benefit women with asthma
New research shows that during natural menstrual cycles, women with asthma who were not taking oral contraceptives (OC) had lower exhaled nitric oxide levels (eNO), a marker of airway inflammation associated with asthma, than women who were taking OC.
Study shows hormone replacement therapy decreases mortality in younger postmenopausal woman
Hormone replacement therapy (HRT) to treat menopausal estrogen deficiency has been in widespread use for over 60 years. Several observational studies over the years showed that HRT use by younger postmenopausal women was associated with a significant reduction in total mortality; available evidence supported the routine use of HRT to increase longevity in postmenopausal women.
Hormone mix could cut breast cancer risk and treat symptoms of menopause
The right combination of estrogen and a selective estrogen receptor modulator (SERM), which blocks the effects of estrogen in breast tissue, could relieve menopause symptoms and cut breast cancer risk.
Breast tenderness during hormone replacement therapy linked to elevated cancer risk
Women who developed new-onset breast tenderness after starting estrogen plus progestin hormone replacement therapy were at significantly higher risk for developing breast cancer than women on the combination therapy who didn't experience such tenderness, according to a new UCLA study.
More Estrogen Current Events and Estrogen News Articles
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Source Naturals Phyto-Estrogen Cream, 4 oz (113.4 g) by Source Naturals Advanced liposomal delivery. Non-GMO soy. Phyto-Estrogen Cream offers some of the finest phytoestregens, renowned for use during menopause. Each ounce contains 60 mg of isoflavone phytoestrogens, along with 150 mg of pomegranate juice extract, and 100 mg of red clover extract. Micro-penetrating liposomes pass through skin layers more easily than non-liposomal creams. | |
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Natural Estrogen with Pomegranate Extract, 60 caplets by Life Extension Natural Estrogen with Pomegranate Extract60 caplets Item Catalog Number: 712 In an attempt to provide aging women with the multiple health effects of the bodies’ estrogen without side effects, scientists have discovered plant extracts with estrogenic activity (phytoestrogens). Natural Estrogen with Pomegranate Extract is one answer to the concerns of maintaining healthy hormone function. A review of the published literature reveals some interesting findings about how plant-derived estrogens can provide safe and effective support for such menopausal symptoms as hot flashes. Derived from organically-grown fruit, the pomegranate extract in this formula has the same ratio of polyphenols found in the whole fruit and all the benefits one would get from the juice without the sugar, calories,... |
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Estrogen/Estriol (Bio-Identical) Fragrance Free Cream 2 oz. Pump Bottle by Radiant Laboratories - Made In USA Paraben-Free and Unscented. Menopausal Hot Flashes? Night Sweats? Trouble Sleeping? Replenish Your Estrogen Naturally and Safely. Get your life back! Estriol Has Been Used in Europe for Years. Bio-identical Hormones Are Safe and Effective. Non Prescription Bio-identical Natural Estrogen (Estriol Usp) Not to Be Confused with Phyto-estrogens. Bio-identical Hormones Are Safe for Women Help Relieve Menopause Symptoms. Estriol is not a phyto estrogen. Don't confuse phyto estrogens with pure natural estriol USP. The natural estrogen, estriol USP, is made the same way natural progesterone USP is made. Sterol analogues found in many varieties of plants are combined with specific bacteria and the resulting hormone is bio identical in chemical structure to the hormone produced by the human body.... |
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Emerita Phytoestrogen Body Cream with Black Cohosh, 2-Ounce Tube by Emerita Peri/Menopause support. Paraben-free. Who knew a little tube of cream could change the world? In 1978 we had a revolutionary idea: that there was not enough real choice when it came to peri / menopause. So we created Pro-Gest, Phytoestrogen Cream and Pers |
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Estroven Maximum Strength - 98 Caplets by Amerifit Estroven Maximum Strength is clinically shown to reduce hot flashes and night sweats. It contains a higher level of the key black cohosh and soy isoflavones ingredients found in Estroven Regular Strength, plus additional vitamins and minerals for women's health. |
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The Greatest Experiment Ever Performed on Women: Exploding the Estrogen Myth, Second Edition by Barbara Seaman (Author) A Library Journal Best Consumer Health Book of 2003 and an American Library Association/Booklist Editor's Choice Book of 2003 "Barbara Seaman is the first prophet of the women's health movement and her prophecies are still coming true."-Gloria Steinem "A wake-up call to women about unquestioningly accepting doctors' orders."-Booklist (starred review) "Lively and impassioned . . . [Seaman] certainly makes her point."-Gina Kolata, The New York Times With the ardent tone of a close friend, Barbara Seaman draws on forty years of journalistic research to expose the "menopause industry" and shows how estrogen therapy often causes more problems-including breast cancer, heart attack, and stroke-than it cures. The Greatest Experiment Ever Performed on Women tracks the... |
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Phyto-Estrogen 60 Capsules by Gaia Herbs Provides a Natural Hormonal Balance During the Onset of Menopause Rich Natural Source of Phytoestrogens Support for the Peri-Menopause and Menopausal Years |
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Alternative Health & Herbs Remedies Female Estrogen W, progesterone, 1-Ounce Bottle by Alternative Health & Herbs Remedies Alternative Health & Herbs Remedies Female Estrogen W, progesterone, promotes hormonal balance, effective for women who are experiencing menopause and it does not contain hormones. |
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TesTo-Rex - 90 Capsules Anti-Estrogen & Anti-Aromatase Complex Testosterone Booster Tribulus Chrysin by PowerNutra The amount of free testosterone can be altered (increased) by the use of aromatase inhibitors such as TesTo-RexTM. The less testosterone that is synthesized [aromatized] into estrogen, the more total testosterone) or inhibitors of the plasma proteins that bind into testosterone. Manipulating the tendency of a testosterone to exist in an unbound state is an effective way to alter the overall activity and potency of ones overall testosterone levels. Higher levels of testosterone produce an enhanced anti-glucocorticoid effect, which yields an anti-catabolic, or more precisely, anti-proteoolytic, effect on muscle cells. This indirect anabolic effect is the result of testosterones high affinity for binding with glucocorticoid receptors, thus blocking the normal messenger pathway that triggers... |
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Estrogen Revisited: Lifelong & Fearless by Donna Walters (Author) Estrogen is essential for good health and well being in women of all ages throughout their lives. I have written this book because I want to encourage women who have been on hormone replacement, like me, to consider remaining on it for life as I plan to do. For women who have been scared or hesitant to take estrogen because they are afraid of contracting breast cancer as predicted by the incorrect conclusions of the Women's Health Initiative in 2002, read this book and save your life. My doctor told me that I should stop taking estrogen because it is recommended for the shortest amount of time to control symptoms only. I have researched this issue for over a year because I want to make the right decision for me. I have decided to share my findings and experience of long term estrogen use... |
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