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Viagra for alleviation of pulmonary hypertension?
September 18, 2002Results of a preliminary study in this week's issue of THE LANCET suggest that Viagra may have a future role in the treatment of pulmonary hypertension (increased blood pressure in the pulmonary artery), a severe and potentially fatal condition causing respiratory impairment.
Lung fibrosis (scarring of the lungs due to inflammation of the alveoli) can be complicated by pulmonary hypertension. Hossein Ardeschir Ghofrani and colleagues from University Hospital, Giessen, Germany, did a preliminary randomised controlled trial to compare the acute effects of oral sildenafil (Viagra) or intravenous epoprostenol (conventional treatment) after the inhalation of nitric oxide in 16 individuals with pulmonary hypertension secondary to lung fibrosis.
A reduction in the ratio of pulmonary to systemic blood resistance-an indication of reduced pulmonary hypertension-was only observed in patients who received sildenafil.
Hossein Ghofrani comments: "Controlled randomised trials should be done to confirm our findings. However, the unique profile of sildenafil, not previously shown for a systemically administered agent, suggests that the drug is a promising candidate for long-term treatment of secondary pulmonary hypertension in lung fibrosis."
In an accompanying Commentary (p 886), Raed A Dweik from the Cleveland Clinic Foundation, USA, states that "the study by Ghofrani and colleagues adds to growing evidence for the use of sildenafil...in patients with primary and secondary pulmonary hypertension", and that sildenafil "is the best available orally administered selective pulmonary vasodilator".
Lancet
Hypertension Current Events and Hypertension News RSSPediatric obesity may alter thyroid function and structure
In addition to its strong associations with hypertension, cardiovascular disease, and diabetes, pediatric obesity may induce alterations in thyroid function and structure, according to a new study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM).
Potassium loss from blood pressure drugs may explain higher risk of adult diabetes
Johns Hopkins researchers have discovered that a drop in blood potassium levels caused by diuretics commonly prescribed for high blood pressure could be the reason why people on those drugs are at risk for developing type 2 diabetes.
Mechanisms of cardiovascular disease and cancer give clues to new therapies
Cardiovascular conditions leading to heart attacks and strokes are treated quite separately from common cancers of the prostate, breast or lung, but now turn out to involve some of the same critical mechanisms at the molecular level.
Very low birth weight is a risk factor for 1 cause of CKD
Individuals who were underweight at birth are at increased risk of developing a condition called secondary focal segmental glomerulosclerosis, according to a study appearing in the January 2009 issue of the Clinical Journal of the American Society Nephrology (CJASN).
Routine Testing After Aneurysm Coiling Carries Low Risk
A very low risk of complication is associated with a routine test that determines whether a brain aneurysm treated with endovascular coiling has started to recur, a study led by the University of Cincinnati Neuroscience Institute has shown.
Low risk for heart attack? Could an ultrasound hold the answer?
By adding the results of an imaging technique to the traditional risk factors for coronary heart disease, doctors at Baylor College of Medicine in Houston found they were able to improve prediction of heart attacks in people previously considered low risk.
Study shows direct link between leptin and obesity-related cardiovascular disease
Obese people who don't have high cholesterol or diabetes might think they're healthy - despite the extra pounds.
Low-dose aspirin does not appear to reduce risk of CV events in patients with diabetes
Low-dose aspirin as primary prevention did not appear to significantly reduce the risk of a combined end point of coronary, cerebrovascular and peripheral vascular events in patients with type 2 diabetes, according to a new study in JAMA.
Pregnancy diabetes doubles the risk of language delay in children
Children born to mothers with pregnancy-related diabetes run twice the risk of language development problems, according to a research team directed by Professor Ginette Dionne of Université Laval's School of Psychology. Details of this discovery are published in the most recent issue of the scientific journal Pediatrics.
Pregnancy disorder signals need to screen for heart disease, study shows
High blood pressure experienced during pregnancy could be a woman's earliest warning that she is at risk of developing heart disease - the number one killer of Canadian women - says Queen's University professor of Obstetrics and Gynecology, Graeme Smith.
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