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Cash boost for research into leukaemia
September 11, 2002Scientists from the University of Sussex in Brighton have been awarded £147,000 by the Leukaemia Research Fund (LRF) to look at abnormalities in DNA damage and repair that occur in some leukaemias and lymphomas.
The research team ľ led by Dr Penny Jeggo at the Genome Damage and Stability Centre ľ will look at Seckel Syndrome, a rare inherited condition. They have recently discovered that a faulty enzyme in Seckel Syndrome prevents the body repairing damaged DNA. Similar defects in DNA repair have been found to predispose some people to certain forms of leukaemia and lymphoma.
This work will throw light on the way this repair mechanism functions and how, when it goes wrong, it can lead to leukaemia and other immune disorders like Seckel Syndrome.
“This research will provide us with a unique insight into what happens in the cell when DNA is damaged,” Dr Jeggo said.
The team believe their findings could make treatments more effective for patients. “Understanding how the damage response mechanisms helps to maintain genetic stability could potentially provide an improved basis for drug targeted treatment,” Dr Jeggo said.
Dr David Grant, Scientific Director of the Leukaemia Research Fund, said: “The failure to repair damaged DNA is an apparent problem and understanding the basis for this will have far-reaching benefits. We see Dr Jeggo’s work as a way forward to more effective treatments for patients with leukaemia and lymphoma.”
Sussex, University of
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Plants display 'molecular amnesia'
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Tool Helps Identify Gene Function in Soybeans, Could Lead to Better Crop Performance, say MU Researchers
In the race for bioengineered crops, sequencing the genome could be considered the first leg in a multi-leg relay.
Brown Chemist Finds Gene That Enables Gray Mold to Kill Plant Cells
Gray mold is a gardener's nightmare. The fungus, also known by its scientific name Botrytis cinerea, is a scourge to more than 200 agricultural and ornamental plant species, including staples such as tomatoes, strawberries, snap and lima beans, cabbage, lettuce and endive, peas, peppers, and potatoes.
Ice beetles impacted by climate change
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Fruit fly research may lead to better understanding of human heart disease
Researchers at the Burnham Institute for Medical Research (Burnham) have shown in both fruit flies and humans that genes involved in embryonic heart development are also integral to adult heart function. The study, led by Rolf Bodmer, Ph.D., was published in Proceedings of National Academy of Sciences.
CSHL scientists discover a new way in which epigenetic information is inherited
Hereditary information flows from parents to offspring not just through DNA but also through the millions of proteins and other molecules that cling to it.
Synthetic virus supports a bat origin for SARS
SARS - severe acute respiratory syndrome - alarmed the world five years ago as the first global pandemic of the 21st century. The coronavirus (SARS-CoV) that sickened more than 8,000 people - and killed nearly 800 of them - may have originated in bats, but the actual animal source is not known.
Scripps Research Scientists Shed Light on How DNA Is Unwound So That Its Code Can Be Read
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