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New Stem Cell Program : Funds Awarded to Nervous System Projects and Stem Cell Bank Networks

September 05, 2002

Nine projects and two extensive networks will share 44 million Swedish kronor (SEK) in research funds, the first grants awarded by Sweden's new Joint Program on Stem Cell Research. Of nearly 50 applicants, 11 received grants. Several of the funded projects address the nervous system. Diabetes is another area to receive funding.

- The entire stem cell field is on the threshold of development. These grants are extremely important for advancing research so that we can identify areas with the greatest potential, says Harriet Wallberg-Henriksson, General Secretary of the Scientific Council for Medicine at the Swedish Research Council. In the long run, it is our hope that stem cells can be used to cure various diseases. However, intensive research is needed before we can say if, and when, this will be possible.

An international panel of five leading experts, all active researchers in the stem cell field, reviewed and evaluated the grant proposals. Selection was based on the quality of the proposals.

Projects selected, project leaders, and funds granted (SEK) for a 3-year period (alphabetical order by surname of project leader):
- Cellular and molecular characterization of stem cell proliferation and differentiation / Ernest Arenas, Karolinska Institutet, Stockholm: 2.7 million SEK
- Survival of neural stem cells and their differentiated progeny in vitro and in vivo / Patrik Brundin, Lund University: 1.5 million SEK
- Genome-wide analysis of genetic reprogramming in neuronal stem cell development / Carlos F Ib'�'�ez, Karolinska Institute: 3 million SEK
- Genetic control of hematopoietic stem cell fate: Therapeutic implications / Stefan Karlsson, Lund University: 2.4 million SEK
- Notch signalling and stem cell differentiation / Urban Lendahl, Karolinska Institutet, Stockholm: 3 million SEK
- Cancer cells, are they stem cells without control? / Monica Nistér, Karolinska Institutet, Stockholm: 2.4 million SEK
- Epigenetic reprogramming and transdifferentiation of somatic cells / Rolf Ohlsson, Uppsala University: 3 million SEK
- Differentiation of functional pancreatic beta cells from human embryonic stem cells / Henrik Semb, Göteborg University: 1.8 million SEK
- Utilization of endothelial-derived signals for differentiating embryonic stem cells to insulin producing cells / Michael Welsh, Uppsala University: 1.8 million SEK
- (network) Network for somatic stem cell plasticity / Sten-Eirik Jacobsen, Lund University: 12 million SEK
- (network) Derivation, characterization, and banking of human embryonic stem cells / Lars Ã"hrlund-Richter, Karolinska Institutet: 10.5 million SEK

Background
Financing for the grants is based an agreement totaling 75 million SEK which the Swedish Research Council reached in the Spring of 2002 with the Juvenile Diabetes Research Foundation (JDRF) in the United States and the Swedish Diabetes Association Research Foundation. Over a 5-year period, JDRF will contribute 50 million SEK, the Swedish Research Council will contribute 20 million SEK, and the Swedish Diabetes Association Research Foundation will contribute 5 million SEK. The program includes 5 million SEK earmarked for research on ethical and legal issues. These grants will be awarded later in the autumn.

VetenskapsrÃ�det (The Swedish Research Council)

Related Stem Cells Current Events and Stem Cells News Articles

Stem Cells Current Events and Stem Cells News RSS

New discovery about the formation of new brain cells
The generation of new nerve cells in the brain is regulated by a peptide known as C3a, which directly affects the stem cells' maturation into nerve cells and is also important for the migration of new nerve cells through the brain tissue, reveals new research from the Sahlgrenska Academy published in the journal Stem Cells.

Umbilical cord blood stem cell transplant may help lung, heart disorders
Two separate studies published in the current issue of Cell Transplantation (18:8), - now freely available on-line have shown that transplanted human-derived umbilical cord blood (UCB) stem cells transplanted in an animal model had positive therapeutic effects on specific lung and heart disorders the animal models.

Gene mismatch influences success of bone marrow transplants
A commonly inherited gene deletion can increase the likelihood of immune complications following bone marrow transplantation, an international team of researchers reports in the November 22 advance online issue of Nature Genetics.

New research shows versatility of amniotic fluid stem cells
For the first time, scientists have demonstrated that stem cells found in amniotic fluid meet an important test of potential to become specialized cell types, which suggests they may be useful for treating a wider array of diseases and conditions than scientists originally thought.

First reconstitution of an epidermis from human embryonic stem cells
Stem cell research is making great strides. This is yet again illustrated by a study carried out by the I-STEM* Institute (I-STEM/ Inserm UEVE U861/AFM), published in the Lancet on 21 November 2009. The I-STEM team, directed by Marc Peschanski has just succeeded in recreating a whole epidermis from human embryonic stem cells.

Bone Implant Offers Hope for Skull Deformities
A synthetic bone matrix offers hope for babies born with craniosynostosis, a condition that causes the plates in the skull to fuse too soon.

Your Own Stem Cells Can Treat Heart Disease
The largest national stem cell study for heart disease showed the first evidence that transplanting a potent form of adult stem cells into the heart muscle of subjects with severe angina results in less pain and an improved ability to walk. The transplant subjects also experienced fewer deaths than those who didn't receive stem cells.

Is hepatic differentiation of embryonic stem cells induced by valproic acid and cytokines?
Embryonic stem (ES) cells, known for their capacity to proliferate indefinitely and differentiate into almost all types of cells including hepatocytes, have raised the hope of cellular replacement therapy for liver failure.

Paradoxical protein might prevent cancer
One difficulty with fighting cancer cells is that they are similar in many respects to the body's stem cells. By focusing on the differences, researchers at Karolinska Institutet have found a new way of tackling colon cancer. The study is presented in the prestigious journal Cell.

U of M researchers find 2 units of umbilical cord blood reduce risk of leukemia recurrence
A new study from the Masonic Cancer Center, University of Minnesota shows that patients who have acute leukemia and are transplanted with two units of umbilical cord blood (UCB) have significantly reduced risk of the disease returning.

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