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Tracking the spread of cancer cells - Photon02
August 28, 2002Not much is known about how clustered cancer cells move, but it is important to understand how individual cancer cells break off from a cluster and spread throughout the human body. A research collaboration between the University of Wales College of Medicine and Kingston University * has lead to the development of a computational imaging technique that tracks the movement of individual cancer cells within cell clusters.
Dr Hoppe, a member of the research team from Kingston University, will be speaking at the Photon02 Conference, in Cardiff on Monday 2 September. He will describe how the research team used a customised microscope fitted with modulation contrast filters to make it easier to see the edges of a single cell. Using the microscope, they studied individual cells within clusters of human colon cancer cells.
The position and velocity of the individual cells was tracked and recorded using a newly developed mathematical computer programme. The programme draws each cell`s boundary on the first digital image and then moves it to the new location in each consecutive image. This is done at a faster rate than was previously possible. Over a two hour period the studied cells were found to have an average speed of 16 micrometres per hour, one micrometre is one millionth of a metre.
Cancer cells usually appear in clusters and there is a suggestion that cell-to-cell adhesions may restrict their mobility. The adhesions are thought to restrict movement in clustered cell populations. Dr Hoppe`s quantitative analysis method for measuring cell movement in clustered cells may therefore help researchers work out how much effect the cell-to-cell adhesion has. This may ultimately provide information about preventing cancer cells from detaching and spreading.
* The research is a collaboration between the Metastasis Research Group, part of the College of Medicine, at the University of Wales and the Digital Imaging Research Centre at Kingston University.
Ends
Institute of Physics
Cancer cells usually appear in clusters and there is a suggestion that cell-to-cell adhesions may restrict their mobility. The adhesions are thought to restrict movement in clustered cell populations. Dr Hoppe`s quantitative analysis method for measuring cell movement in clustered cells may therefore help researchers work out how much effect the cell-to-cell adhesion has. This may ultimately provide information about preventing cancer cells from detaching and spreading.
* The research is a collaboration between the Metastasis Research Group, part of the College of Medicine, at the University of Wales and the Digital Imaging Research Centre at Kingston University.
Ends
Institute of Physics
Cancer Cells Current Events and Cancer Cells News RSSResearchers Identify Role of Gene in Tumor Development, Growth and Progression
Virginia Commonwealth University Massey Cancer Center and VCU Institute of Molecular Medicine researchers have identified a gene that may play a pivotal role in two processes that are essential for tumor development, growth and progression to metastasis.
Cancer metabolism discovery uncovers new role of IDH1 gene mutation in brain cancer
Agios Pharmaceuticals today announced that its scientists have established, for the first time, that the mutated IDH1 gene has a novel enzyme activity consistent with a cancer-causing gene, or oncogene.
New cancer target for non-Hodgkin's lymphoma
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Cancers' Sweet Tooth May Be Weakness
The pedal-to-the-metal signals driving the growth of several types of cancer cells lead to a common switch governing the use of glucose, researchers at Winship Cancer Institute of Emory University have discovered.
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Paradoxical protein might prevent cancer
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Aileron collaborates study in Nature: Stapled peptides inhibit Notch1 transcription factor
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