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Gastrointestinal symptoms not linked to later autism
August 21, 2002Children with autism are no more likely than children without autism to have had gastrointestinal disorders, finds a study in this week`s BMJ.
Researchers at Boston University identified 96 children with autism from the UK General Practice Research Database between 1988 and 1999. Each case was matched with up to five children without autism. They also considered the time relation between measles, mumps, and rubella vaccination and the onset of gastrointestinal symptoms among the cases.
They found no increase in a history of gastrointestinal disorders, coeliac disease, food intolerance, or recurrent gastrointestinal symptoms among children with autism compared with those without autism. They also found no temporal association between measles, mumps, and rubella vaccination and the onset of gastrointestinal symptoms in children with autism.
The authors cannot exclude the possibility that some children in the study had subclinical gastrointestinal symptoms before their presentation with autistic behaviour. However, the children described by Wakefield and colleagues had symptomatic gastrointestinal disease.
They also cannot exclude the possibility that severe gastrointestinal disease may be associated with the development of autism in certain individuals. However, their results indicate that if this occurs, it is likely to be uncommon.
"Our results are consistent with those of other studies in providing evidence against a substantial association between gastrointestinal illness in children and the later development of autism," they conclude.
British Medical Journal (BMJ)
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New molecular insight into vertebrate brain development
In the December 1st issue of G&D, Dr. Fred H. Gage (The Salk Institute for Biological Studies) and colleagues reveal a role for the Hippo signaling pathway in the regulation of vertebrate neural development, identifying new factors - and potential therapeutic targets - that may be involved in congenital brain size disorders and neurological tumor formation.
AMA journal publishes by Cornell Researchers study showing evidence of a major environmental trigger for autism
The American Medical Association journal Archives of Pediatrics & Adolescent Medicine has published a new study by researchers at Cornell University indicating evidence of an environmental trigger for autism among genetically vulnerable children.
Unusual use of toys in infancy a clue to later autism
Researchers at the UC Davis M.I.N.D. Institute have found that infants later diagnosed with autism exhibited unusual exploration of objects long before being diagnosed.
Genetic study provides new insights into molecular basis of language development
Scientists have identified the first gene that is associated with a common childhood language disorder, known as specific language impairment (SLI).
Methylmercury warning
Recent studies hint that exposure to the toxic chemicals, such as methylmercury can cause harm at levels previously considered safe.
Supercomputer provides massive computational boost to biomedical research at TGen
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