 |
|
Nature press release for 15 August issue
August 20, 2002[1] LIFELINES: APES LACK ELEMENTS OF LANGUAGE GENE
(DOI: 10.1038/nature01025) (http://dx.doi.org/10.1038/nature01025)
***This paper will be published electronically on Nature`s website on 14 August at 1900 London time / 1400 US Eastern time (which is also when the embargo lifts) as part of our AOP (ahead of print) programme. Although we have included it on this release to avoid multiple mailings it will not appear in print on 15 August, but at a later date.***
Language, a uniquely human trait, relies on capabilities such as fine control of the larynx and mouth. In a paper published online in Nature this week, researchers have begun to work out why chimpanzees and other great apes lack these abilities.
Last year, scientists identified the first gene, called FOXP2, definitively linked to human language; members of a family with mutations in this gene have severe language and grammar difficulties.
Now Svante Paabo of the Max Planck Institute for Evolutionary Anthropology, Leipzig, and colleagues have examined this gene in the chimpanzee, gorilla, orang-utan, rhesus macaque and mouse and compared them with the human version.
Human FOXP2 contains a key change in its sequence compared with the other animals, they found, and is under selection for the human-specific change. The sequence changes may affect a person`s ability to control facial movements and thus to develop proficient spoken language, they speculate.
The gene variant that permits language may have become widespread in the population during the last 200,000 years of human history, they estimate - around the same time that anatomically modern humans emerged - suggesting that language may have been a driving force in their expansion.
CONTACT:
Svante Paabo (until 10th August) tel + 49 341 9952 501, e-mail paabo@eva.mpg.de
Wolfgang Enard (co-author) (after 10th August) tel +49 341 9952 511,
e-mail enard@eva.mpg.de
[2] LIFELINES: CROSS-SPECIES TESTES TRANSPANT (pp778-781)
Researchers have produced sperm from pig and goat testes grafted onto mice. Future human-to-mouse grafts could help restore fertility to men who have undergone cancer therapy, and other interspecies grafts could help conserve endangered species.
Scientists have previously grafted testis tissue from one mouse to another - but previous grafts between mammalian species have not produced sperm. Ina Dobrinski of the School of Veterinary Medicine, University of Pennsylvania, Kennett Square, and colleagues devised a technique to graft fragments of tissue from immature testes of newborn pigs or goats under the skin of mice whose immune systems were deficient. More than 60% of the grafts survived and produced working sperm, they report in Nature.
Unlike sperm cryopreservation, grafting testis tissue from humans into a mouse host and use of the resultant sperm for assisted fertilization provides a potentially endless supply of sperm. Testis tissue grafts could also contribute to conserving endangered species or valuable livestock by allowing sperm production from immature males. It could also be used as a method for studying the effects of toxins and male contraceptives on testis function.
CONTACT:
tel +1 610 444 5800 ext. 2563, e-mail dobrinsk@vet.upenn.edu
[3] PHYSICS: EXCITONS CREATE RIPPLES (pp751-754 and 754-757)
Two papers in Nature this week describe a bizarre light phenomenon created by excitons, bound pairs of electrons and holes that can form in semiconductor systems.
Light from excitons generated by a laser pulse in quantum wells appears up to 1 millimetre away from the laser excitation spot with almost none in between, say L. V. Butov of the Lawrence Berkeley National Laboratory, University of California, Berkeley, and the Russian Academy of Sciences, Chernogolovka, and colleagues, and D. Snoke of the University of Pittsburgh, Pennsylvania, and his team. This is like a drop falling into water - but only a single circular ripple appearing some distance away. The finding implies that excitons must travel in a dark state and then revert to a luminescent state at a critical distance.
Physicists hope to use measurements of excitons, which can form quantum liquids at low temperatures, to understand other quantum liquids such as superconductors, liquid helium and Bose-Einstein condensates, whose ordered structures are very difficult to probe.
CONTACT:
L. V. Butov tel +1 510 486 7475, e-mail lvbutov@lbl.gov
D. Snoke tel +1 412 624 9007, e-mail snoke@pitt.edu
[4] LIFELINES: ENDURANCE GENE MAKES MUSCLES MIGHTY (pp797-801)
US scientists have created transgenic mice whose muscles tire slowly during exercise. Human skeletal muscles contain about half slow-twitch and half fast-twitch fibres. Slow-twitch muscles are the ones that can cope with the repeated muscle contractions required for endurance, in part because they contain more energy-generating mitochondria.
Bruce M. Spiegelman of the Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, and his team made transgenic mice that produce the `slow-twitch` protein PGC-1 - which switches on mitochondrial proliferation and metabolism - in muscle cells that are normally fast-twitch. The muscle fibres convert to slow-twitch, they show in this week's Nature, and as a consequence are more resistant to fatigue.
PGC-1 may affect glucose uptake and turnover in cells under the
influence of insulin, the authors add, and hence these findings could have implications in obesity and diabetes.
CONTACT:
Bruce M. Spiegelman tel +1 617 632 3567, e-mail bruce_spiegelman@dfci.harvard.edu
[5] BRAIN: COFFEE`S KICK BETWEEN CUPS EXPLAINED (pp774-778; N&V)
A protein that intensifies and prolongs caffeine`s kick is identified in this week`s Nature.
Although caffeine is probably the world's most widely used psychostimulant, surprisingly little is known about its molecular mechanism. At concentrations equivalent to a few cups of coffee a day, it binds and blocks nerve cells that normally inhibit voluntary movements in the brain`s movement centre, the striatum.
Gilberto Fisone of the Karolinska Institute, Stockholm, Sweden, and colleagues found that a protein called DARPP-32 is the key to the action of coffee: mice genetically engineered to lack DARPP-32 are immune to some of its stimulatory effects, they report.
Low doses of caffeine appear to trigger a positive feedback loop in striatal nerves: they subdue a protein called protein kinase A, which in turn keeps DARPP-32 phosphorylated. In this form, it dampens protein kinase A further. Together with other molecules in the feedback loop, they control the activity of further proteins that inhibit nerve activity, and thus keep us hyperactive.
"DARPP-32 keeps us going until the next coffee break by extending the effects of the last cup," says Jean-Marie Vaugeois of the University of Rouen, France, in an associated News and Views article.
CONTACT:
Gilberto Fisone tel +46 8728 7375, e-mail gilberto.fisone@neuro.ki.se
Jean-Marie Vaugeois tel +33 2 35 14 86 02, e-mail jean-marie.vaugeois@univ-rouen.fr
[6] PHYSICS: SUPERCONDUCTOR`S SECRETS EXPLORED (pp758-760; N&V)
The discovery that magnesium diboride (MgB2) can superconduct at remarkably high temperatures (39 kelvin) generated much excitement in the field: MgB2 is cheap, readily available, and may even be amenable to being made into wires.
In this week`s Nature, Steven G. Louie of the University of California at Berkeley, and the Lawrence Berkeley National Laboratory, Berkeley, and colleagues have come up with a model to better understand MgB2`s superconducting properties.
Materials carry a superconducting current when electrons are induced to form pairs. The tracer of the binding energy of the pairs is called the energy gap, because energy put into the superconductor is absorbed by the pairs to separate the electrons. Recent experiments indicate that electrons in MgB2 may have two different binding energies. The new model confirms its `double-energy-gap` nature - and predicts many of the remarkable characteristics of MgB2 as a superconductor.
"Novel superconductors will continue to appear in unexpected ways," predicts Warren Pickett of the University of California, Davis, in an accompanying News and Views article.
CONTACT:
Steven G. Louie tel +1 510 642 1709, e-mail sglouie@uclink.berkeley.edu
Warren Pickett tel +1 530 752 0926, e-mail pickett@physics.ucdavis.edu
[7] LIFELINES: MALARIA VACCINE TARGETS TOXIN (pp785-789)
Researchers in this week`s Nature present a novel approach to developing a vaccine against malaria.
There is a long history of attempts to develop antimalarial vaccines, but little success. All current malarial vaccine candidates are aimed at target proteins in the various life stages of the malarial parasite, Plasmodium falciparum.
Louis Schofield of the Walter and Eliza Hall Institute of Medical Research in Melbourne, Australia, and colleagues show, using a mouse malaria model, that a vaccine targeted at a toxin released by the parasite may be more effective. Mice inoculated with a chemically synthesized fragment of glycosylphosphatidylinositol (GPI) were protected against many of the signs of malaria, and against death.
The findings demonstrate the potential of synthetic GPI in anti-toxic vaccines, and suggest that GPI is responsible for some symptoms of malaria in humans.
CONTACT:
Louis Schofield tel +61 3 9345 2474, e-mail schofield@wehi.edu.au
[8] EARTH: SLAB COLLAPSE MAY CAUSE MAGMA ERUPTION (pp763-767; N&V)
Why volcanoes in the northwest Pacific Ocean once spouted huge volumes of magma may be explained in this week`s Nature.
Vadim Levin of Yale University, New Haven, Connecticut, and colleagues took seismic images in the upper 200 kilometres of the Earth. They pictured a region where the Aleutian and Kamchatka subduction zones - places where one tectonic plate plunges below another - meet. In this region, the Pacific plate and North American plate also collide.
On the basis of the features they observed, they argue that there have been two periods of huge slab disintegration where the oceanic plates collided - one five to ten million years ago and another two million years ago.
The second piece of broken-off slab forced down into the hot mantle might have caused huge upflow of hot material, explaining the world-record magma output of the overlying Klyuchevsky volcano, they suggest. Confirming this theory will require investigation of similar geological regions in the world, says J. Huw Davies of Cardiff University, UK, in an accompanying News and Views article.
CONTACT:
Vadim Levin tel +1 203 432 3279, e-mail vadim.levin@yale.edu
J. Huw Davies tel +44 292 087 5182, e-mail huw@earth.cf.ac.uk
[9] LIFELINES: SILKWORMS SPIN TUFF (p741)
The gossamer-like product of the silkworm`s toil is getting a bad rap, according to a Brief Communication to this week`s Nature. The strength and flexibility of their silk can be nearly as good as that of spiders - currently championed as producers of the ultimate silk - provided it is extracted under the right conditions.
Zhenghong Shao of Fudan University in Shanghai, China, and Fritz Vollrath, at Oxford University, UK, show that by carefully extracting silk directly from silkworms (the caterpillar of the silk moth, Bombyx mori) rather than from finished cocoons, the properties of the resulting silk approach spider quality.
Previous experiments showed that silk from web-spinning spiders is about three times as strong and more than twice as stretchy as silkworm silk. But these experiments compared spider silk with silkworm silk extracted in the way used to produce silk commercially - by washing and unwinding it from caterpillar-spun cocoons.
But spooling silk as it comes out of the caterpillar`s silk glands changes its properties markedly, Shao and Vollrath find. Slow spooling makes silkworm silk as stretchy as spider silk, and fast spooling makes it tougher, although not quite as strong as spider silk.
They argue that materials with the desirable properties of spider silk could be harvested commercially either by inducing silkworms to spin in a different way or by modifying silk collection techniques, without having to resort to genetically engineering silkworms (which has been suggested). Harvesting silk from spiders is not regarded as feasible.
CONTACT:
Zhenghong Shao (no tel number), e-mail zzshao@fudan.edu.cn
Fritz Vollrath (co-author) tel +44 1865 271 216, e-mail fritz.vollrath@zoo.ox.ac.uk
[10] LIFELINES: MALARIA FEELS THE HEAT (p742)
Temperature is crucial to changes in the life stages of the parasite responsible for malaria, according to a Brief Communication to this week`s Nature.
To pass from mosquito to human and back to mosquito again, the parasite Plasmodium falciparum must go through three life stages, one that goes from mosquito to human, one that reproduces in the human, and one that returns to mosquitoes.
Jun Fang and Thomas McCutchan at the National Institute of Allergy and Infectious Diseases in Bethesda, Maryland, find that certain genes in P. falciparum are transcribed more efficiently at cooler temperatures. This thermoregulatory adaptation could be crucial to how the parasite copes with changes in temperature when it moves between hosts.
CONTACT:
Thomas McCutchan tel +1 301 496 6149, e-mail tmccutchan@niaid.nih.gov
[11] AND FINALLY: TARZAN`S VINES GO WILD (pp770-774)
A letter to this week`s Nature reports good news for Tarzan, but potentially bad news for our climate`s future.
Oliver Phillips of Leeds University, UK, and colleagues report that the numbers of lianas - tree-climbing vines and preferred mode of transport for the king of the jungle - are increasing in the Amazon rainforest. In some parts of the forest they are nearly twice as many big lianas now than there were twenty years ago.
Tree-killing lianas, the researchers argue, could reduce the ability of tropical forests like the Amazon to absorb greenhouse gas carbon dioxide. Lianas break tree limbs and block out sunlight, causing trees to grow slower and convert less carbon dioxide into plant material.
The reason for the increase in lianas remains unclear. But the researchers speculate that, paradoxically, increasing levels of carbon dioxide in the atmosphere could be feeding liana growth.
The finding, they argue, shows the importance of `biosphere feedbacks` - changes in climate or atmospheric conditions affecting ecosystems like forests, which change how they in turn have an impact on the climate and atmosphere.
CONTACT:
Oliver L. Phillips tel +44 1132 333 308, e-mail oliverp@geog.leeds.ac.uk
ALSO IN THIS ISSUE
[12] The influence of a chemical boundary layer on the fixity, spacing and lifetime of mantle plumes (pp760-763)
[13] A primitive fish close to the common ancestor of tetrapods and lungfish (pp767-770)
[14] Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck (pp760-793; N&V)
[15] Modulation of an RNA-binding protein by abscisic-acid-activated protein kinase (pp793-797)
GEOGRAPHICAL LISTING OF AUTHORS
The following list of places refers to the whereabouts of authors on the papers numbered in this release. The listing may be for an author`s main affiliation, or for a place where they are working temporarily. Please see the PDF of the paper for full details.
AUSTRALIA
Melbourne: 7
BOLIVIA
Santa Cruz: 11
CHINA
Beijing: 13
Shanghai: 9
DENMARK
Odense: 14
ECUADOR
Quito: 11
GERMANY
Leipzig: 1
Münster: 2
ITALY
Milan: 5
JAPAN
Fukuoka: 15
PERU
Cusco: 11
Jaen: 11
RUSSIA
Chernogolovka: 3
SWEDEN
Stockholm: 5
UNITED KINGDOM
Edinburgh: 11
Leeds: 11
Oxford: 1, 9
UNITED STATES OF AMERICA
California
Berkeley: 3, 6, 12
Santa Barbara: 3
Colorado
Boulder: 8
Connecticut
New Haven: 8
District of Columbia
Washington DC: 11
Maryland
Bethesda: 10
Massachusetts
Boston: 4, 14, 15
Cambridge: 7
Missouri
St. Louis: 11
New Jersey
Murray Hill: 3
Union: 13
New York State
New York: 5, 11
Pennsylvania
Kennett Square: 2
Pittsburgh: 3
University Park:
Texas
Dallas: 4, 5
Nature Publishing Group Reference
Last year, scientists identified the first gene, called FOXP2, definitively linked to human language; members of a family with mutations in this gene have severe language and grammar difficulties.
Now Svante Paabo of the Max Planck Institute for Evolutionary Anthropology, Leipzig, and colleagues have examined this gene in the chimpanzee, gorilla, orang-utan, rhesus macaque and mouse and compared them with the human version.
Human FOXP2 contains a key change in its sequence compared with the other animals, they found, and is under selection for the human-specific change. The sequence changes may affect a person`s ability to control facial movements and thus to develop proficient spoken language, they speculate.
The gene variant that permits language may have become widespread in the population during the last 200,000 years of human history, they estimate - around the same time that anatomically modern humans emerged - suggesting that language may have been a driving force in their expansion.
CONTACT:
Svante Paabo (until 10th August) tel + 49 341 9952 501, e-mail paabo@eva.mpg.de
Wolfgang Enard (co-author) (after 10th August) tel +49 341 9952 511,
e-mail enard@eva.mpg.de
[2] LIFELINES: CROSS-SPECIES TESTES TRANSPANT (pp778-781)
Researchers have produced sperm from pig and goat testes grafted onto mice. Future human-to-mouse grafts could help restore fertility to men who have undergone cancer therapy, and other interspecies grafts could help conserve endangered species.
Scientists have previously grafted testis tissue from one mouse to another - but previous grafts between mammalian species have not produced sperm. Ina Dobrinski of the School of Veterinary Medicine, University of Pennsylvania, Kennett Square, and colleagues devised a technique to graft fragments of tissue from immature testes of newborn pigs or goats under the skin of mice whose immune systems were deficient. More than 60% of the grafts survived and produced working sperm, they report in Nature.
Unlike sperm cryopreservation, grafting testis tissue from humans into a mouse host and use of the resultant sperm for assisted fertilization provides a potentially endless supply of sperm. Testis tissue grafts could also contribute to conserving endangered species or valuable livestock by allowing sperm production from immature males. It could also be used as a method for studying the effects of toxins and male contraceptives on testis function.
CONTACT:
tel +1 610 444 5800 ext. 2563, e-mail dobrinsk@vet.upenn.edu
[3] PHYSICS: EXCITONS CREATE RIPPLES (pp751-754 and 754-757)
Two papers in Nature this week describe a bizarre light phenomenon created by excitons, bound pairs of electrons and holes that can form in semiconductor systems.
Light from excitons generated by a laser pulse in quantum wells appears up to 1 millimetre away from the laser excitation spot with almost none in between, say L. V. Butov of the Lawrence Berkeley National Laboratory, University of California, Berkeley, and the Russian Academy of Sciences, Chernogolovka, and colleagues, and D. Snoke of the University of Pittsburgh, Pennsylvania, and his team. This is like a drop falling into water - but only a single circular ripple appearing some distance away. The finding implies that excitons must travel in a dark state and then revert to a luminescent state at a critical distance.
Physicists hope to use measurements of excitons, which can form quantum liquids at low temperatures, to understand other quantum liquids such as superconductors, liquid helium and Bose-Einstein condensates, whose ordered structures are very difficult to probe.
CONTACT:
L. V. Butov tel +1 510 486 7475, e-mail lvbutov@lbl.gov
D. Snoke tel +1 412 624 9007, e-mail snoke@pitt.edu
[4] LIFELINES: ENDURANCE GENE MAKES MUSCLES MIGHTY (pp797-801)
US scientists have created transgenic mice whose muscles tire slowly during exercise. Human skeletal muscles contain about half slow-twitch and half fast-twitch fibres. Slow-twitch muscles are the ones that can cope with the repeated muscle contractions required for endurance, in part because they contain more energy-generating mitochondria.
Bruce M. Spiegelman of the Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, and his team made transgenic mice that produce the `slow-twitch` protein PGC-1 - which switches on mitochondrial proliferation and metabolism - in muscle cells that are normally fast-twitch. The muscle fibres convert to slow-twitch, they show in this week's Nature, and as a consequence are more resistant to fatigue.
PGC-1 may affect glucose uptake and turnover in cells under the
influence of insulin, the authors add, and hence these findings could have implications in obesity and diabetes.
CONTACT:
Bruce M. Spiegelman tel +1 617 632 3567, e-mail bruce_spiegelman@dfci.harvard.edu
[5] BRAIN: COFFEE`S KICK BETWEEN CUPS EXPLAINED (pp774-778; N&V)
A protein that intensifies and prolongs caffeine`s kick is identified in this week`s Nature.
Although caffeine is probably the world's most widely used psychostimulant, surprisingly little is known about its molecular mechanism. At concentrations equivalent to a few cups of coffee a day, it binds and blocks nerve cells that normally inhibit voluntary movements in the brain`s movement centre, the striatum.
Gilberto Fisone of the Karolinska Institute, Stockholm, Sweden, and colleagues found that a protein called DARPP-32 is the key to the action of coffee: mice genetically engineered to lack DARPP-32 are immune to some of its stimulatory effects, they report.
Low doses of caffeine appear to trigger a positive feedback loop in striatal nerves: they subdue a protein called protein kinase A, which in turn keeps DARPP-32 phosphorylated. In this form, it dampens protein kinase A further. Together with other molecules in the feedback loop, they control the activity of further proteins that inhibit nerve activity, and thus keep us hyperactive.
"DARPP-32 keeps us going until the next coffee break by extending the effects of the last cup," says Jean-Marie Vaugeois of the University of Rouen, France, in an associated News and Views article.
CONTACT:
Gilberto Fisone tel +46 8728 7375, e-mail gilberto.fisone@neuro.ki.se
Jean-Marie Vaugeois tel +33 2 35 14 86 02, e-mail jean-marie.vaugeois@univ-rouen.fr
[6] PHYSICS: SUPERCONDUCTOR`S SECRETS EXPLORED (pp758-760; N&V)
The discovery that magnesium diboride (MgB2) can superconduct at remarkably high temperatures (39 kelvin) generated much excitement in the field: MgB2 is cheap, readily available, and may even be amenable to being made into wires.
In this week`s Nature, Steven G. Louie of the University of California at Berkeley, and the Lawrence Berkeley National Laboratory, Berkeley, and colleagues have come up with a model to better understand MgB2`s superconducting properties.
Materials carry a superconducting current when electrons are induced to form pairs. The tracer of the binding energy of the pairs is called the energy gap, because energy put into the superconductor is absorbed by the pairs to separate the electrons. Recent experiments indicate that electrons in MgB2 may have two different binding energies. The new model confirms its `double-energy-gap` nature - and predicts many of the remarkable characteristics of MgB2 as a superconductor.
"Novel superconductors will continue to appear in unexpected ways," predicts Warren Pickett of the University of California, Davis, in an accompanying News and Views article.
CONTACT:
Steven G. Louie tel +1 510 642 1709, e-mail sglouie@uclink.berkeley.edu
Warren Pickett tel +1 530 752 0926, e-mail pickett@physics.ucdavis.edu
[7] LIFELINES: MALARIA VACCINE TARGETS TOXIN (pp785-789)
Researchers in this week`s Nature present a novel approach to developing a vaccine against malaria.
There is a long history of attempts to develop antimalarial vaccines, but little success. All current malarial vaccine candidates are aimed at target proteins in the various life stages of the malarial parasite, Plasmodium falciparum.
Louis Schofield of the Walter and Eliza Hall Institute of Medical Research in Melbourne, Australia, and colleagues show, using a mouse malaria model, that a vaccine targeted at a toxin released by the parasite may be more effective. Mice inoculated with a chemically synthesized fragment of glycosylphosphatidylinositol (GPI) were protected against many of the signs of malaria, and against death.
The findings demonstrate the potential of synthetic GPI in anti-toxic vaccines, and suggest that GPI is responsible for some symptoms of malaria in humans.
CONTACT:
Louis Schofield tel +61 3 9345 2474, e-mail schofield@wehi.edu.au
[8] EARTH: SLAB COLLAPSE MAY CAUSE MAGMA ERUPTION (pp763-767; N&V)
Why volcanoes in the northwest Pacific Ocean once spouted huge volumes of magma may be explained in this week`s Nature.
Vadim Levin of Yale University, New Haven, Connecticut, and colleagues took seismic images in the upper 200 kilometres of the Earth. They pictured a region where the Aleutian and Kamchatka subduction zones - places where one tectonic plate plunges below another - meet. In this region, the Pacific plate and North American plate also collide.
On the basis of the features they observed, they argue that there have been two periods of huge slab disintegration where the oceanic plates collided - one five to ten million years ago and another two million years ago.
The second piece of broken-off slab forced down into the hot mantle might have caused huge upflow of hot material, explaining the world-record magma output of the overlying Klyuchevsky volcano, they suggest. Confirming this theory will require investigation of similar geological regions in the world, says J. Huw Davies of Cardiff University, UK, in an accompanying News and Views article.
CONTACT:
Vadim Levin tel +1 203 432 3279, e-mail vadim.levin@yale.edu
J. Huw Davies tel +44 292 087 5182, e-mail huw@earth.cf.ac.uk
[9] LIFELINES: SILKWORMS SPIN TUFF (p741)
The gossamer-like product of the silkworm`s toil is getting a bad rap, according to a Brief Communication to this week`s Nature. The strength and flexibility of their silk can be nearly as good as that of spiders - currently championed as producers of the ultimate silk - provided it is extracted under the right conditions.
Zhenghong Shao of Fudan University in Shanghai, China, and Fritz Vollrath, at Oxford University, UK, show that by carefully extracting silk directly from silkworms (the caterpillar of the silk moth, Bombyx mori) rather than from finished cocoons, the properties of the resulting silk approach spider quality.
Previous experiments showed that silk from web-spinning spiders is about three times as strong and more than twice as stretchy as silkworm silk. But these experiments compared spider silk with silkworm silk extracted in the way used to produce silk commercially - by washing and unwinding it from caterpillar-spun cocoons.
But spooling silk as it comes out of the caterpillar`s silk glands changes its properties markedly, Shao and Vollrath find. Slow spooling makes silkworm silk as stretchy as spider silk, and fast spooling makes it tougher, although not quite as strong as spider silk.
They argue that materials with the desirable properties of spider silk could be harvested commercially either by inducing silkworms to spin in a different way or by modifying silk collection techniques, without having to resort to genetically engineering silkworms (which has been suggested). Harvesting silk from spiders is not regarded as feasible.
CONTACT:
Zhenghong Shao (no tel number), e-mail zzshao@fudan.edu.cn
Fritz Vollrath (co-author) tel +44 1865 271 216, e-mail fritz.vollrath@zoo.ox.ac.uk
[10] LIFELINES: MALARIA FEELS THE HEAT (p742)
Temperature is crucial to changes in the life stages of the parasite responsible for malaria, according to a Brief Communication to this week`s Nature.
To pass from mosquito to human and back to mosquito again, the parasite Plasmodium falciparum must go through three life stages, one that goes from mosquito to human, one that reproduces in the human, and one that returns to mosquitoes.
Jun Fang and Thomas McCutchan at the National Institute of Allergy and Infectious Diseases in Bethesda, Maryland, find that certain genes in P. falciparum are transcribed more efficiently at cooler temperatures. This thermoregulatory adaptation could be crucial to how the parasite copes with changes in temperature when it moves between hosts.
CONTACT:
Thomas McCutchan tel +1 301 496 6149, e-mail tmccutchan@niaid.nih.gov
[11] AND FINALLY: TARZAN`S VINES GO WILD (pp770-774)
A letter to this week`s Nature reports good news for Tarzan, but potentially bad news for our climate`s future.
Oliver Phillips of Leeds University, UK, and colleagues report that the numbers of lianas - tree-climbing vines and preferred mode of transport for the king of the jungle - are increasing in the Amazon rainforest. In some parts of the forest they are nearly twice as many big lianas now than there were twenty years ago.
Tree-killing lianas, the researchers argue, could reduce the ability of tropical forests like the Amazon to absorb greenhouse gas carbon dioxide. Lianas break tree limbs and block out sunlight, causing trees to grow slower and convert less carbon dioxide into plant material.
The reason for the increase in lianas remains unclear. But the researchers speculate that, paradoxically, increasing levels of carbon dioxide in the atmosphere could be feeding liana growth.
The finding, they argue, shows the importance of `biosphere feedbacks` - changes in climate or atmospheric conditions affecting ecosystems like forests, which change how they in turn have an impact on the climate and atmosphere.
CONTACT:
Oliver L. Phillips tel +44 1132 333 308, e-mail oliverp@geog.leeds.ac.uk
ALSO IN THIS ISSUE
[12] The influence of a chemical boundary layer on the fixity, spacing and lifetime of mantle plumes (pp760-763)
[13] A primitive fish close to the common ancestor of tetrapods and lungfish (pp767-770)
[14] Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck (pp760-793; N&V)
[15] Modulation of an RNA-binding protein by abscisic-acid-activated protein kinase (pp793-797)
GEOGRAPHICAL LISTING OF AUTHORS
The following list of places refers to the whereabouts of authors on the papers numbered in this release. The listing may be for an author`s main affiliation, or for a place where they are working temporarily. Please see the PDF of the paper for full details.
AUSTRALIA
Melbourne: 7
BOLIVIA
Santa Cruz: 11
CHINA
Beijing: 13
Shanghai: 9
DENMARK
Odense: 14
ECUADOR
Quito: 11
GERMANY
Leipzig: 1
Münster: 2
ITALY
Milan: 5
JAPAN
Fukuoka: 15
PERU
Cusco: 11
Jaen: 11
RUSSIA
Chernogolovka: 3
SWEDEN
Stockholm: 5
UNITED KINGDOM
Edinburgh: 11
Leeds: 11
Oxford: 1, 9
UNITED STATES OF AMERICA
California
Berkeley: 3, 6, 12
Santa Barbara: 3
Colorado
Boulder: 8
Connecticut
New Haven: 8
District of Columbia
Washington DC: 11
Maryland
Bethesda: 10
Massachusetts
Boston: 4, 14, 15
Cambridge: 7
Missouri
St. Louis: 11
New Jersey
Murray Hill: 3
Union: 13
New York State
New York: 5, 11
Pennsylvania
Kennett Square: 2
Pittsburgh: 3
University Park:
Texas
Dallas: 4, 5
Nature Publishing Group Reference
Malaria Current Events and Malaria News RSSOn the Trail of a Vaccine for Lyme Disease: Yale Researchers Target Tick Saliva
A protein found in the saliva of ticks helps protect mice from developing Lyme disease, Yale researchers have discovered. The findings, published in the November 19 issue of Cell Host & Microbe, may spur development of a new vaccine against infection from Lyme disease, which is spread through tick bites.
Research calls for better assessment of tests for tuberculosis, HIV/AIDS and malaria
A rapid and accurate diagnosis is the first step towards treatment in the fight against infectious disease.
Small nanoparticles bring big improvement to medical imaging
If you're watching the complex processes in a living cell, it is easy to miss something important-especially if you are watching changes that take a long time to unfold and require high-spatial-resolution imaging.
Prioritizing low-cost, simple health measures would save 2.5 million child lives a year
Almost a third of the children under age five who die each year could be saved if governments rebalance health spending to ensure low-cost, simple interventions such as safe water and hygiene, bed nets and basic maternal and newborn care, leading aid agency World Vision said today. Currently, 8.8 million children a year die before age five, most of preventable causes.
Drug industry, nonprofits join forces to fight world's neglected diseases
Drug companies and nonprofit organizations are joining forces to develop new drugs and vaccines to target so-called "neglected" diseases that claim millions of lives in the developing world each year.
U.S. and European Experts Applaud Creation of New Transatlantic Task Force on Global Antibiotic Resistance Threat
Experts on both sides of the Atlantic applaud President Barack Obama and Swedish Prime Minister Fredrik Reinfeldt, representing the European Union (EU) Presidency, for establishing a transatlantic task force to address antibiotic resistance, an urgent and growing problem that threatens patient safety and public health worldwide.
1930s drug slows tumor growth
Drugs sometimes have beneficial side effects. A glaucoma treatment causes luscious eyelashes. A blood pressure drug also aids those with a rare genetic disease.
DNA barcodes: Creative new uses span health, fraud, smuggling, history, more
The scientific ability to quickly and accurately identify species through DNA "barcoding" is being embraced and applied by a growing legion of global authorities - from medical and agricultural researchers to police and customs authorities to palaeontologists and others.
PATH Malaria Vaccine Initiative shares strategy for developing 'next-generation' malaria vaccines
Marking its tenth anniversary year, the PATH Malaria Vaccine Initiative (MVI) today unveiled a new strategy that sets the stage for an aggressive push targeting the long-term goal of eliminating and eradicating malaria. Malaria is one of the world's deadliest infectious diseases, killing nearly 900,000 people a year, most of them children in sub-Saharan Africa.
Global challenges and opportunities in fighting HIV/AIDS and neglected diseases
Responding to the HIV/AIDS pandemic and tackling so-called neglected tropical diseases are the focus of the November/December 2009 edition of Health Affairs.
More Malaria Current Events and Malaria News Articles
 |
The Making of a Tropical Disease: A Short History of Malaria (Johns Hopkins Biographies of Disease) by Randall M. Packard (Author) Malaria sickens hundreds of millions of people -- and kills one to three million -- each year. Despite massive efforts to eradicate the disease, it remains a major public health problem in poorer tropical regions. But malaria has not always been concentrated in tropical areas. How did other regions control malaria and why does the disease still flourish in some parts of the globe? From Russia to Bengal to Palm Beach, Randall Packard's far-ranging narrative traces the natural and social forces that help malaria spread and make it deadly. He finds that war, land development, crumbling health systems, and globalization -- coupled with climate change and changes in the distribution and flow of water -- create conditions in which malaria's carrier mosquitoes thrive. The combination of... |
 |
The Malaria Capers : More Tales of Parasites and People, Research and Reality by Robert S. Desowitz (Author) "Reads like a murder mystery. . . . [Desowitz] writes with uncommon lucidity and verse, leaving the reader with a vivid understanding of malaria and other tropical diseases, and the ways in which culture, climate and politics have affected their spread and containment."—New York Times Why, Robert S. Desowitz asks, has biotechnical research on malaria produced so little when it had promised so much? An expert in tropical diseases, Desowtiz searches for answers in this provocative book. . |
 |
Compiled 1981-1984 by Malaria! |
 |
Humanity's Burden: A Global History of Malaria (Studies in Environment and History) by James L.A. Webb Jr. (Author) Humanity's Burden provides a panoramic overview of the history of malaria. It traces the long arc of malaria out of tropical Africa into Eurasia, its transfer to the Americas during the early years of the Columbian exchange, and its retraction from the middle latitudes into the tropics since the late nineteenth century. Adopting a broadly comparative approach to historical patterns and processes, it synthesizes research findings from the natural and social sciences and weaves these understandings into a narrative that reaches from the earliest evidence of malaria infections in tropical Africa up to the present. Written in a style that is easily accessible to non-specialists, it considers the significance of genetic mutations, diet, lifestyle, migration, warfare, palliative and curative... |
 |
First Comes Love, Then Comes Malaria: How a Peace Corps Poster Boy Won My Heart and a Third World Adventure Changed My Life by Eve Brown-Waite (Author) In this laugh-out-loud funny memoir, a pampered city girl falls head over little black heels in love with a Peace Corps poster boy and follows him —literally–to the ends of the earth. Eve Brown always thought she would join the Peace Corps someday, although she secretly worried about life without sushi, frothy coffee drinks and air conditioning. But with college diploma in hand, it was time to put up or shut up. So with some ambivalence she arrives at the Peace Corps office–sporting her best safari chic attire –to casually look into the steps one might take if one were to become a global humanitarian, a la Angelina Jolie. But when Eve meets John, her dashing young Peace Corps recruiter, all her ambivalence flies out the window. She absolutely must join the Peace Corps -... |
![GIANTmicrobes: Malaria (Plasmodium Falciparum) [Toy]](http://ecx.images-amazon.com/images/I/21%2BeHMzjARL._SL160_.jpg) |
GIANTmicrobes: Malaria (Plasmodium Falciparum) [Toy] by Giant Microbes GIANTmicrobes are fun and educationala great way to learn about various health topics and the microscopic critters that are found in and around us. Each microbe character is 5-7 in size--over a million times their actual size! Perfect for teachers, parents and budding scientiststhey also make humorous gifts. Each microbe comes with an information tag including scientific name, an image of the actual microbe, and a mini history and science lesson. Not suitable for children under 3 years. Our products are made by top manufacturers who care about toy safety, quality and value. Your order will ship factory fresh directly from our warehouse to your door. We carefully inspect and beautifully package every order before shipment to ensure that you receive high quality products that are... |
 |
Molecular Approaches to Malaria by Irwin W. Sherman (Editor) "Molecular Approaches to Malaria" provides an overview of the rapid and significant developments that have occurred in malaria research, including the 2002 genome sequencing of Plasmodium falciparum and its mosquito vector, Anopheles gambiae. This work: provides a concise source of up-to-date research findings; appeals to a diverse audience, including malaria researchers, teachers, investigators, and public health professionals; offers contributions by recognized malaria researchers with practical experience; and, presents comprehensive coverage of topics including a clearly written introduction to Plasmodium molecular biology. |
 |
Malaria: Fever Wars Starring: Artist Not Provided |
 |
Sea to Summit Personal Mosquito Shelter (Double) by Sea to Summit An indispensible item for traveling or backpacking in bug infested regions. The Sea to Summit Mosquito Net shelters are small, light and compact. Available in a Permetherin treated version. Handy stuff sack for easing packing included. Double version has 22 spreader pole that packs down to 6. |
 |
Revisited by Malaria! |
| © 2009 BrightSurf.com |