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Prion Research Center to open today - Hebrew University-hadassah Medical School Researchers Working To Prevent Mad Cow Disease
July 31, 2002Prion Research Center to open today
Jerusalem, July 31, 2002 - Scientists around the world are striving to learn as much as possible about the phenomenon that causes mad cow disease so that they will be prepared if and when an epidemic breaks out, according to Dr. Albert Taraboulos of the Institute of Microbiology of the Hebrew University-Hadassah Medical School. He explained that the exact incubation period of the disease is unknown and so scientists are working hard to ensure that they are not caught unprepared.
Dr. Taraboulos and his research team are trying to develop drugs that can prevent people from contracting the disease and drugs that can cure those who have contracted it. They also are trying to determine how prions, the molecular agent that causes mad cow disease (or BSE), propagate.
The outbreak of mad cow disease in Europe, and the finding that this fatal neurodegeneration has transmitted to humans, have signaled the appearance of a worldwide health threat and have brought prions to the forefront of public attention. BSE is just one of many prion diseases. Prions are an exception in biology in that they have no genes. In fact, prions are just a corrupt form of one of the patient's protein, and by corrupting more of our own protein they proliferate and cause disease. Prions are infectious, and more than 100 people have already succumbed to the human form of mad cow disease in Europe. The discovery in Israel, last month, of a cow sick with BSE has demonstrated that Israel is not immune to infectious prions.
Prion disorders are also unique in that they can also be inherited (through a mutation in the prion protein gene). Familial prion diseases include the well known Creutzfeldt-Jakob disease (CJD). Israel has had a long acquaintance with prions. In fact, the largest cluster of familial CJD in the world is found in Israel. A better understanding of prions also may improve understanding of Alzheimer's disease.
These circumstances have spurred the Hebrew University of Jerusalem and the Hadassah Medical Organization to create the Prion Research Center dedicated to the research of prion diseases in Israel. Located at the Faculty of Medicine, Ein Kerem campus in Jerusalem, this center will conduct and coordinate research programs and epidemiological studies on prions diseases. The center will exploit the extensive prion expertise that is already in place at the campus, particularly in the laboratory of Prof. Ruth Gabizon at the department of Neurology in Hadassah and Dr. Taraboulos' research team, as well as cooperate with researchers from Israel and abroad.
The new center will combine clinical and basic activities. It will try to improve diagnostic procedures, and will attempt to develop therapies. It will collaborate extensively with government and regulatory agencies in Israel and abroad. It is hoped that the new center will help cull the danger of prion spread in Israel and alleviate patient suffering.
The Prion Research Center will open at a ceremony on Wednesday, July 31 at 5:30 p.m. at the Hebrew University-Hadassah Medical School in Ein Kerem, Jerusalem.
British Medical Journal (BMJ)
The outbreak of mad cow disease in Europe, and the finding that this fatal neurodegeneration has transmitted to humans, have signaled the appearance of a worldwide health threat and have brought prions to the forefront of public attention. BSE is just one of many prion diseases. Prions are an exception in biology in that they have no genes. In fact, prions are just a corrupt form of one of the patient's protein, and by corrupting more of our own protein they proliferate and cause disease. Prions are infectious, and more than 100 people have already succumbed to the human form of mad cow disease in Europe. The discovery in Israel, last month, of a cow sick with BSE has demonstrated that Israel is not immune to infectious prions.
Prion disorders are also unique in that they can also be inherited (through a mutation in the prion protein gene). Familial prion diseases include the well known Creutzfeldt-Jakob disease (CJD). Israel has had a long acquaintance with prions. In fact, the largest cluster of familial CJD in the world is found in Israel. A better understanding of prions also may improve understanding of Alzheimer's disease.
These circumstances have spurred the Hebrew University of Jerusalem and the Hadassah Medical Organization to create the Prion Research Center dedicated to the research of prion diseases in Israel. Located at the Faculty of Medicine, Ein Kerem campus in Jerusalem, this center will conduct and coordinate research programs and epidemiological studies on prions diseases. The center will exploit the extensive prion expertise that is already in place at the campus, particularly in the laboratory of Prof. Ruth Gabizon at the department of Neurology in Hadassah and Dr. Taraboulos' research team, as well as cooperate with researchers from Israel and abroad.
The new center will combine clinical and basic activities. It will try to improve diagnostic procedures, and will attempt to develop therapies. It will collaborate extensively with government and regulatory agencies in Israel and abroad. It is hoped that the new center will help cull the danger of prion spread in Israel and alleviate patient suffering.
The Prion Research Center will open at a ceremony on Wednesday, July 31 at 5:30 p.m. at the Hebrew University-Hadassah Medical School in Ein Kerem, Jerusalem.
British Medical Journal (BMJ)
Prions Current Events and Prions News RSSThe Protein Srebp2 Drives Cholesterol Formation in Prion-Infected Neuronal Cells Which May Promote Prion-Dependent Diseases
The regulating protein Srebp2 drives cholesterol formation, which prions need for their propagation, in prion-infected neuronal cells.
Cell study explains why younger people more at risk of vCJD
Specific cells within the immune system could help explain why younger people are more susceptible to variant CJD, scientists believe.
Prion study reveals first direct information about the protein's molecular structure
A collaboration between scientists at Vanderbilt University and the University of California, San Francisco has led to the first direct information about the molecular structure of prions.
One nano-step closer to weighing a single atom
By studying gold nanoparticles with highly uniform sizes and shapes, scientists now understand how they lose energy, a key step towards producing nanoscale detectors for weighing any single atom.
Scripps Florida scientists devise accelerated method to determine infectious prion strainsScripps Florida scientists devise accelerated method to determine infectious prion strains
Current tests to identify specific strains of infectious prions, which cause a range of transmissible diseases (such as mad cow) in animals and humans, can take anywhere from six months to a year to yield results - a time-lag that may put human populations at risk.
Redefining what it means to be a prion
Whitehead Institute researchers have quintupled the number of identifiable prion proteins in yeast and have further clarified the role prions play in the inheritance of both beneficial and detrimental traits.
Prion discovery gives clue to control of mass gene expression
The discovery in common brewer's yeast of a new, infectious, misfolded protein -- or prion -- by University of Illinois at Chicago molecular biologists raises new questions about the roles played by these curious molecules, often associated with degenerative brain diseases like "mad cow" and its human counterpart, Creutzfeldt-Jakob.
Antibody key to treating variant CJD, scientists find
Scientists at the University of Liverpool have determined the atomic structure of the 'binding' between a brain protein and an antibody that could be key to treating patients with diseases such as variant CJD.
Self-regulating molecular 'transformers' control intracellular protein delivery
Scientists from the California Institute of Technology (Caltech) have uncovered the Transformer like properties of molecules responsible for carrying and depositing proteins to their correct locations within cells.
Study confirms vCJD could be transmitted by blood transfusion
The findings underline the importance of precautions against vCJD transmission, such as the Government decision in 2004 to ban blood donations from anyone who had received a blood transfusion since 1980.
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