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Research Probes Soy - Prostate Cancer Link

July 30, 2002

Researchers at the University of Ulster and Belfast City Hospital are set to launch a groundbreaking study that could offer a new insight into the prevention of prostate cancer.

The study will focus on a significant link between low levels of serious prostate cancer and the presence of soy products in the diet.

Professor Ian Rowland, from the University of Ulster said: "The incidence and mortality rate of certain cancers such as colorectal and prostate cancers, is much higher in Western countries than in the East.

"It is thought that this may be due to the differences in the foods people eat in different parts of the world. Studies suggest that it is the high amounts of soy food that people eat in Eastern countries, such as Japan and China, that helps protect them against prostate cancer .

"People in Western countries, like here in Northern Ireland, do not eat much soy at all-so we could be missing out on a protective effect.

"This link between high soy consumption and low prostate cancer mortality is backed up by studies using animal fed high soy diets and by laboratory research using prostate cancer cells treated with compounds extracted from soy beans. Now what we need is evidence that soy can help to prevent the onset of prostate cancer, or, slow its progression, in humans. This is the primary aim of the new research project."

The study will be carried out in collaboration with Dr Patrick Keane at Belfast City Hospital. Men attending the hospital for a biopsy of the prostate, will be invited to take part.

Participants will be given milk drinks containing soy compounds over a four month period. Biological markers that indicate prostate cancer risk will then be measured to see whether the soy-rich diet had any beneficial effects. Any changes in the prostate cells themselves can also be detected.

Professor Rowland highlighted the worrying number of cases of prostate cancer in the province and stressed the importance of the new study: "Statistics from the Northern Ireland Cancer Registry show that at least 470 new cases of prostate cancer are reported each year in Northern Ireland, and that prostate cancer causes around 200 deaths here per year.

"It is the second most common cause of cancer death in males in Northern Ireland, and is catching up with lung cancer. Both incidence and mortality are increasing. That is why investigating new ways to prevent, or minimise the effects of the disease is so crucial."

Ulster, University of