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Longer Delays Associated With Better Survival
July 24, 2002Patients who experience the longest delay in treatment are more likely to survive, despite the popular assumption that delay has a significant and harmful impact on survival, finds a study in this week's BMJ.
Researchers collected data from the case notes of 703 women resident in Scotland who were diagnosed between 1 January 1996 and 31 December 1997 as having endometrial cancer. They calculated time intervals from the dates of general practitioner referral letters, clinic appointments, investigations, and operations.
They found that delay and survival were inversely related: women with the shortest delay had more advanced disease and survival was least likely for these patients.
The traditional view is that delay caused by organisational defects has an adverse effect on the disease: this influences survival. "Our study suggests that disease influences delay, and so delay is a confounding factor," say the authors.
The fact that the strongest effect between delay and survival is seen in the interval between referral and the first hospital visit suggests that general practitioners communicate information related to presentation in some way to consultants, they add. This communication ensures that consultants respond faster to patients who are at higher risk.
Consultants seem to be able, from first clinic visit, to differentiate patients at greater risk and to ensure that cancer is diagnosed and treated faster, they conclude.
British Medical Journal (BMJ)
The traditional view is that delay caused by organisational defects has an adverse effect on the disease: this influences survival. "Our study suggests that disease influences delay, and so delay is a confounding factor," say the authors.
The fact that the strongest effect between delay and survival is seen in the interval between referral and the first hospital visit suggests that general practitioners communicate information related to presentation in some way to consultants, they add. This communication ensures that consultants respond faster to patients who are at higher risk.
Consultants seem to be able, from first clinic visit, to differentiate patients at greater risk and to ensure that cancer is diagnosed and treated faster, they conclude.
British Medical Journal (BMJ)
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First use of antibody and stem cell transplantation to successfully treat advanced leukemia
For the first time, researchers at Fred Hutchinson Cancer Research Center have reported the use of a radiolabeled antibody to deliver targeted doses of radiation, followed by a stem cell transplant, to successfully treat a group of leukemia and pre-leukemia patients for whom there previously had been no other curative treatment options.
New Notre Dame study provides insights into the molecular basis of tumor cell behavior
A new study by a team of researchers led by Crislyn D'Souza-Schorey, associate professor of biological sciences at the University of Notre Dame, sheds light on the molecular basis by which tumor cells modulate their surroundings to favor cancer progression.
Researcher: 'Optical biopsy' for breast cancer increasingly accurate
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Plastic surgeons offer microsurgery technique for breast reconstruction, tummy tuck after mastectomy
Since her teens, Jennifer Jablon had watched family members deal with breast cancer during their 40s, 50s, and 60s. She wondered whether it would be her fate too.
Newly revised guidelines for managing thyroid cancer published in Thyroid journal
The American Thyroid Association has released new, revised Management Guidelines for the diagnosis and treatment of patients with thyroid nodules and thyroid cancer.
New Synthetic Molecules Trigger Immune Response to HIV and Prostate Cancer
Researchers at Yale University have developed synthetic molecules capable of enhancing the body's immune response to HIV and HIV-infected cells, as well as to prostate cancer cells. Their findings, published online in the Journal of the American Chemical Society, could lead to novel therapeutic approaches for these diseases.
Magnetic nanoparticles to simultaneously diagnose, monitor and treat
Whether it's magnetic nanoparticles (mNPs) giving an army of 'therapeutically armed' white blood cells direction to invade a deadly tumour's territory, or the use of mNPs to target specific nerve channels and induce nerve-led behaviour (such as the life-dependant thumping of our hearts), mNPs have come a long way in the past decade.
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