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Prostate Cancer Survival Benefit From A Combination Of Androgen Suppression And External Irradiation
July 05, 2002Disease-free survival from advanced prostate cancer could be almost doubled if hormone-suppression therapy is used during and after radiotherapy for a duration of 3 years, suggest authors of an international study in this week's issue of THE LANCET.
Long-term survival after radiotherapy for people with advanced prostate cancer is poor. Michel Bolla from University Hospital, Grenoble, France, and colleagues investigated the added value of long-term male-hormone (androgen) suppression in locally advanced prostate cancer.
415 patients with advanced prostate cancer were randomly assigned radiotherapy or radiotherapy and immediate androgen suppression. Average follow-up time was five and a half years.
Patients given combined radiotherapy and hormone-suppression therapy had a substantially increased five-year disease-free survival rate (74%) than patients given radiotherapy alone (40%). Overall survival rates were 78% for combined therapy and 62% for radiotherapy alone.
Michel Bolla comments: "androgen suppression provides a means of improving the outcome of external irradiation alone, by possibly eliminating occult disease. Moreover androgen suppression and external irradiation appear to have an additive effect on local disease control by inducing apoptosis [tumour-cell death]".
Lancet
Prostate Cancer News and Current Prostate Cancer Events RSSToo much calcium in blood may increase risk of fatal prostate cancer
Men who have too much calcium in their bloodstreams may have an increased risk of fatal prostate cancer, according to a new analysis from Wake Forest University School of Medicine and the University of Wisconsin.
Height linked to risk of prostate cancer development and progression
A man's height is a modest marker for risk of prostate cancer development, but is more strongly linked to progression of the cancer, say British researchers who conducted their own study on the connection and also reviewed 58 published studies.
Health risk behaviors associated with lower prostate specific antigen awareness
According to a study conducted at Columbia University Mailman School of Public Health, health risk behaviors such as smoking and obesity are associated with lower awareness of the Prostate Specific Antigen (PSA), which could lead to a lower likelihood of undergoing actual prostate cancer screening.
Study shows PDE5 inhibitor more effective when used on demand in erectile dysfunction
European Urology, the official journal of the European Association of Urology will be featuring the article 'Effect of nightly versus on-demand vardenafil on recovery of erectile function in men following bilateral nerve-sparing radical prostatectomy' by F. Montorsi et al.in the October issue, showing for the first time that vardenafil, a PDE5 inhibitor, is more efficacious when used on-demand in men with erectile dysfunction, supporting a shift towards on-demand dosing with PDE5 inhibitors in this patient group.
Satisfaction and regret after radical prostatectomy procedures studied
Studies have shown that approximately 16% of patients with localised prostate cancer regret their treatment choice. European Urology, the official journal of the European Association of Urology, will be publishing an article by J.W. Moul et al. comparing differences in satisfaction and regret between patients who underwent open retropubic radical prostatectomy and robot-assisted laparoscopic radical prostatectomy.
State's first single incision robotic kidney removal
For the first time in Michigan, a diseased kidney has been surgically removed at Henry Ford Hospital using highly sophisticated 3D robotics through a single incision.
Anti-tumor effects are enhanced by inhibiting 2 pathways rather than 1
Two independent research groups have found that simultaneous inhibition of two signaling pathways resulted in substantially enhanced antitumor effects in mouse models of prostate and breast cancer. In an accompany commentary, Steven Grant, at Virginia Commonwealth University Health Science Center, Richmond, discusses the clinical importance of these studies and highlights some of the questions that still need to be answered.
Why a common treatment for prostate cancer ultimately fails
Some of the drugs given to many men during their fight against prostate cancer can actually spur some cancer cells to grow, researchers have found. The findings were published online this week in a pair of papers in the Proceedings of the National Academy of Sciences.
PSA screening may be biased against obese men, leading to more aggressive cancers
Testing men for elevated levels of prostate-specific antigen (PSA) in the blood -- the gold standard screening test for prostate cancer -- may be biased against obese men, whose PSA levels tend to be deceptively low.
Study finds more PSA screening awareness needed among high-risk groups
In one of the first examinations of PSA screening in younger men, a study published by researchers at Duke Medicine's Prostate Center finds that one-fifth of men under age 50 reported undergoing a prostate specific antigen (PSA) test to detect prostate cancer in the previous year, yet only one in three young black men reported ever having a PSA test in the previous year.
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