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Diabetes targets will be impractical in routine practice
June 26, 2002Targets due to be set as part of the national service framework for diabetes in England and Wales will be impractical for use in routine clinical care, according to an article in this week’s BMJ.
Aggressive treatment of high levels of blood sugar, cholesterol, and blood pressure and regular use of antiplatelet drugs has been advocated in type 2 diabetes. Yet current targets are attainable in only 50-70% of individuals in research studies, argues Peter Winocour of Queen Elizabeth II Hospital in Hertfordshire.
The targets are often impractical and involve taking too many drugs, with which patients often will not comply, he adds. Individually tailored targets would be preferable, taking account of factors such as estimated duration of diabetes, obesity, age and lifestyle.
Given the cardiovascular risk profile of type 2 diabetes, up to 10% of patients could require as many as nine drugs. A high proportion will also require treatment for existing heart disease and coincidental unrelated chronic disease, says the author. “It is difficult to see how we can realistically expect patients to comply for long with such a draconian regimen requiring so many separate drugs.”
He concludes: “The development of combination tablets by the pharmaceutical industry seems of the utmost priority for effective prevention of complications of type 2 diabetes. Until then we must be pragmatic. We should set targets that are reasonable for our clinics and our individual patients.”
British Medical Journal (BMJ)
Given the cardiovascular risk profile of type 2 diabetes, up to 10% of patients could require as many as nine drugs. A high proportion will also require treatment for existing heart disease and coincidental unrelated chronic disease, says the author. “It is difficult to see how we can realistically expect patients to comply for long with such a draconian regimen requiring so many separate drugs.”
He concludes: “The development of combination tablets by the pharmaceutical industry seems of the utmost priority for effective prevention of complications of type 2 diabetes. Until then we must be pragmatic. We should set targets that are reasonable for our clinics and our individual patients.”
British Medical Journal (BMJ)
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Diabetes surgery summit consensus lays foundation for new field of medicine
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New research shows versatility of amniotic fluid stem cells
For the first time, scientists have demonstrated that stem cells found in amniotic fluid meet an important test of potential to become specialized cell types, which suggests they may be useful for treating a wider array of diseases and conditions than scientists originally thought.
First reconstitution of an epidermis from human embryonic stem cells
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An atomic-level look at an HIV accomplice
Since the discovery in 2007 that a component of human semen called SEVI boosts infectivity of the virus that causes AIDS, researchers have been trying to learn more about SEVI and how it works, in hopes of thwarting its infection-promoting activity.
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Scientists find molecular trigger that helps prevent aging and disease
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Pivotal study for PSD502 -- the first potential treatment for premature ejaculation
At the annual meeting of the Sexual Medicine Society of North America (SMSNA), Inc. in San Diego, Sciele Pharma, Inc., a Shionogi Company and Plethora Solutions Limited, a wholly owned subsidiary of Plethora Solutions Holdings PLC ("Plethora" - AIM:PLE)., today presented data from its second positive pivotal study of PSD502 for the treatment of premature ejaculation (PE).
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