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Oestrogen may be associated with virus (HPV) infection implicated in cervical cancer
June 17, 2002The female hormone oestrogen may have a role in HPV viral infection, strains of which are implicated in cervical cancer, shows research in Sexually Transmitted Infections.
Human papillomavirus (HPV) infection is a common genital infection seen most often in young women and adolescents. There are often no visible signs of infection.
Researchers tested 175 sexually active women for HPV infection during routine examinations at a sexual health clinic. The women were all aged between 14 and 44. Over half were younger than 25.
They also investigated how many oestrogen receptors - cells that are specifically activated by the female hormone - were present in the neck of the womb (cervix). The women also completed a questionnaire, detailing their sexual and menstrual histories.
Four out of 10 women tested positive for HPV, mostly HPV 16, the strain linked to cervical cancer. Six women had two strains, and one had three. The younger the woman, the greater was her risk of infection. But starting sex at an early age was not a high risk factor for the infection, the research showed.
Almost all the women with HPV infection had detectable levels of oestrogen receptors. Every 10 per cent increase in receptor numbers tripled the likelihood of HPV infection.
Clearly, say the authors, younger women will have higher oestrogen levels than older women, but there was no obvious association between menstrual cycle - at certain times of which circulating oestrogen levels are higher - and the numbers of oestrogen receptors detected. And the association between oestrogen receptors and HPV held for older women as well.
It may be that some women are ‘biologically vulnerable’ to HPV because of the numbers of oestrogen receptors they have in their cervix, say the authors, and suggest that these receptors may in some way facilitate infection with the virus.
British Medical Journal (BMJ)
They also investigated how many oestrogen receptors - cells that are specifically activated by the female hormone - were present in the neck of the womb (cervix). The women also completed a questionnaire, detailing their sexual and menstrual histories.
Four out of 10 women tested positive for HPV, mostly HPV 16, the strain linked to cervical cancer. Six women had two strains, and one had three. The younger the woman, the greater was her risk of infection. But starting sex at an early age was not a high risk factor for the infection, the research showed.
Almost all the women with HPV infection had detectable levels of oestrogen receptors. Every 10 per cent increase in receptor numbers tripled the likelihood of HPV infection.
Clearly, say the authors, younger women will have higher oestrogen levels than older women, but there was no obvious association between menstrual cycle - at certain times of which circulating oestrogen levels are higher - and the numbers of oestrogen receptors detected. And the association between oestrogen receptors and HPV held for older women as well.
It may be that some women are ‘biologically vulnerable’ to HPV because of the numbers of oestrogen receptors they have in their cervix, say the authors, and suggest that these receptors may in some way facilitate infection with the virus.
British Medical Journal (BMJ)
Cervical Cancer Current Events and Cervical Cancer News RSSLSUHSC public health contributes to estimate of HPV-related cancers
Professor Vivien Chen, PhD,. Associate Professor Xiao Cheng Wu, MD, PhD and Assistant Professor Edward Peters, DMD, SM, ScD, at LSU Health Sciences Center New Orleans School of Public Health contributed five papers to the largest most comprehensive assessment of the burden of human papillomavirus (HPV)-associated cancers in the United States to date.
The health burden of raising a grandchild
Precautionary health measures such as mammograms and cholesterol tests that identify the risk of heart disease are critical for the well-being of women over 50. Add the responsibility of providing sustained care for a grandchild, and these preventive examinations become even more important.
Healthy bones program reduces hip fractures by 37 percent
Proactive measures can reduce hip fracture rates by an average of 37.2 percent -- and as much as 50 percent -- among those at risk, according to a study conducted by Kaiser Permanente Southern California. The study was published online on November 3 by The Journal of Bone & Joint Surgery, a peer-reviewed journal.
New MRI technique may identify cervical cancer early
Using high-resolution magnetic resonance imaging (MRI) with a special vaginal coil, a technique to measure the movement of water within tissue, researchers may be able to identify cervical cancer in its early stages, according to a new study being published in the November issue of Radiology.
Cancer screening rates among older Medicaid patients fall short of national objectives
Only about half of Medicaid recipients age 50 and older appear to receive recommended screening tests for colorectal, breast and cervical cancer, according to a report in the October 13 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.
Social class dictates cancer risk
Cervical and lung cancer are more common in poor people while rates of breast cancer and melanoma are higher in the wealthy.
Model highlights benefits and risks of cervical cancer screening methods
In an analysis based on a computer model, it appears that comparing the benefits and risks of different cervical cancer prevention approaches may help women and their physicians choose appropriate screening strategies.
New HPV test for developing countries shows high accuracy in predicting cervical disease: Study
A new HPV test developed by QIAGEN specifically for use in regions of the world with scarce resources is "substantially" more accurate in identifying women with cervical disease than the current methods (Pap testing and visual inspection) in these countries.
As head and neck cancer risks evolve, more treatment options emerge
Advances in understanding head and neck cancer over the last decade have led to more treatment options and improved quality of life for patients, according to a review published this week in the New England Journal of Medicine.
Cervical cancer prevention should focus on vaccinating adolescent girls
The cost-effectiveness of vaccination in the United States against human papillomavirus (HPV), a sexually-transmitted virus that causes cervical cancer, will be optimized by achieving universal vaccine coverage in young adolescent girls, by targeting initial "catch-up" efforts to vaccinate women younger than 21 years of age, and by revising current screening policies.
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