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New Diagnostic Faecal Test Could Identify Colorectal Cancer (p 1917)
May 29, 2002Authors of a research letter in this week's issue of THE LANCET describe a new technique where the detection of a specific protein in faeces could be a marker for colorectal cancer.
Colorectal cancer is a common disease (causing around 500,000 deaths each year worldwide), and screening methods that are more reliable than colonoscopy and faecal-blood assessment are needed for earlier disease detection. Nicholas Coleman and colleagues from the MRC Cancer Cell Unit, Cambridge, UK, aim to develop a non-invasive, stool-based assessment that can identify a specific protein - minichromosome maintenance protein 2 (MCM2) - which is present in cancerous colorectal cells but not normal cells.
In a clinical study, the investigators detected MCM2-positive cells from 37 of 40 patients known to have colorectal cancer; there was no detection of the protein in any of the 25 healthy individuals (the control group).
Nicholas Coleman comments: "These findings suggest that detection of MCM2 in colonocytes retrieved from the faecal surface might be of value in the non-invasive diagnosis of malignant colorectal disease. The conditions of this study do not represent those of a general screening setting, and our findings might have differed in a population with a higher frequency of cancers of the right-side of the colon. Nevertheless, despite the requirement for rapid stool processing, our approach might ultimately prove suitable for population screening, either alone or in combination with other tests."
Lancet
Nicholas Coleman comments: "These findings suggest that detection of MCM2 in colonocytes retrieved from the faecal surface might be of value in the non-invasive diagnosis of malignant colorectal disease. The conditions of this study do not represent those of a general screening setting, and our findings might have differed in a population with a higher frequency of cancers of the right-side of the colon. Nevertheless, despite the requirement for rapid stool processing, our approach might ultimately prove suitable for population screening, either alone or in combination with other tests."
Lancet
Colorectal Cancer Current Events and Colorectal Cancer News RSSIrritable Bowel Syndrome patients not at more risk of colon cancer, polyps
Patients with irritable bowel syndrome are at no greater risk of having polyps, colon cancer or inflammatory bowel diseases than healthy people undergoing colonoscopies, according to new research published in the American Journal of Gastroenterology.
Like little golden assassins, 'smart' nanoparticles identify, target and kill cancer cells
Another weapon in the arsenal against cancer: Nanoparticles that identify, target and kill specific cancer cells while leaving healthy cells alone.
High weight associated with risk of colorectal tumors without microsatellite instability
The increased risk of colorectal cancer associated with obesity may be largely restricted to tumors that have no or low microsatellite instability (MSI), a common condition in most colorectal cancers, according to a new study published online March 8 in the Journal of the National Cancer Institute.
A new indicator of poor prognosis in node-negative colorectal cancer patients
Tumor budding at the invasive tumor front of colorectal cancer is recognized as an independent prognostic factor significantly related to both lymph node and distant metastasis.
Researchers find that sociodemographic characteristics are related to a patient's willingness to participate in cancer screenings
Boston University School of Medicine's (BUSM) researchers have found that sociodemographic characteristics are related to a patients' willingness to participate in cancer screenings.
Gene signature may improve colon cancer treatment
A gene signature, first identified in mouse colon cancer cells, may help identify patients at risk of colon cancer recurrence, according to a recent study by Vanderbilt-Ingram Cancer Center researchers.
Those who have colonoscopy performed by GIs less likely to develop colorectal cancer
Following a negative complete colonoscopy, those who had their colonoscopies at a hospital and had their procedures performed by a non-gastroenterologist may be at a significantly increased risk of developing subsequent colorectal cancer (CRC).
VARI Findings May Help Patients with Deadly Kidney Cancer
Van Andel Research Institute (VARI) researchers have found a way to reverse resistance to sunitinib, a treatment that is currently the first line of defense against clear cell renal cell carcinoma (ccRCC), a deadly form of kidney cancer.
AGA offers new recommendations for CRC surveillance for certain patients with IBD
Certain patients with inflammatory bowel disease (IBD), both ulcerative colitis and Crohn's disease of the colon, have an increased risk of developing colorectal cancer compared to individuals without IBD.
Helicobacter pylori and EBV in gastric carcinomas
Gastric cancer, one of the most common types of cancer, is associated with high mortality rates. In the last decades, a decrease in the worldwide incidence has been observed with some changes in the therapeutic and diagnostic options.
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Current Medical Literature : Colorectal Cancer by Current Medical Literature Ltd | |
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