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NO ASSOCIATION BETWEEN AGEING GAMETES AND BIRTH DEFECTS
May 08, 2002Authors of a research letter in this week's issue of THE LANCET conclude that there is no evidence to support the belief that sexual intercourse too soon or two long after ovulation is associated with an increased risk of birth defects and Down's syndrome.
For many years, the ageing of gametes as a result of prolonged retention in the female reproductive tract before fertilisation has been circumstantially associated with major birth defects. Joe Leigh Simpson and colleagues from Baylor College of Medicine, Houston, USA, studied over 1000 pregnant women from Chile, Colombia, Italy, and the USA, who had recorded the timing (with regard to presumed ovulation) of sexual intercourse leading to conception.
There were no significant differences in the proportion of birth defects in infants born to mothers who reported optimally timed conceptions (on the day of or one day before ovulation) than infants born to mothers who reported non-optimally timed conceptions (2.7% compared with 2.5%, respectively). There was also no significant difference in the proportion of infants born with Down's syndrome (0.5% for optimally timed conceptions compared with 0.7% for non-optimally timed conceptions).
Joe Leigh Simpson comments: "Overall, our findings are reassuring for users of natural family planning, for couples who have intercourse episodically, or for couples who have intercourse infrequently of their own volition for health or other reasons."
Lancet
Joe Leigh Simpson comments: "Overall, our findings are reassuring for users of natural family planning, for couples who have intercourse episodically, or for couples who have intercourse infrequently of their own volition for health or other reasons."
Lancet
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Phthalates are important components of many consumer products, including toys, cleaning materials, plastics, and personal care items.
Causative gene of a rare disorder discovered by sequencing only protein-coding regions of genome
For the first time, scientists have successfully used a method called exome sequencing to quickly discover a previously unknown gene responsible for a mendelian disorder.
Women at risk from vitamin A deficiency
Almost half of UK women could be suffering from a lack of vitamin A due to a previously undiscovered genetic variation, scientists at Newcastle University have found.
Chromosomes dance and pair up on the nuclear membrane
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Local health investigation sheds light on gastroschisis birth defect
Results of an investigation conducted by University of Nevada, Reno researchers, public health officials and area physicians published this week in the Archives of Pediatrics & Adolescent Medicine, indicate that Washoe County experienced a cluster of a particular birth defect, gastroschisis, during the period April 2007 - April 2008.
NIH-funded researchers transform embryonic stem cells into human germ cells
Researchers funded in part by the National Institutes of Health have discovered how to transform human embryonic stem cells into germ cells, the embryonic cells that ultimately give rise to sperm and eggs.
Fetal study highlights impact of stress on male fertility
Exposure to a combination of excess stress hormones and chemicals while in the womb could affect a man's fertility in later life, a study suggests.
Major improvements made in engineering heart repair patches from stem cells
University of Washington (UW) researchers have succeeded in engineering human tissue patches free of some problems that have stymied stem-cell repair for damaged hearts.
OU Part of International Study on Genetic Impact of Radiation
Researchers at the University of Oklahoma Health Sciences Center are helping to lead a massive international study on the possible genetic effects of radiation and cancer drug exposures on future generations.
Global death toll: 1 million premature babies every year
More than one million infants die each year because they are born too early, according to the just released White Paper, The Global and Regional Toll of Preterm Birth.
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