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THE LANCET ONCOLOGY (TLO) AND THE LANCET INFECTIOUS DISEASES (TLID)
May 01, 2002THE LANCET ONCOLOGY (TLO)
CHERNOBYL, IONISING RADIATION EXPOSURE, AND CANCER RISK
The first review in this month’s TLO reviews the epidemiological evidence linking cancer incidence as a result of the 1986 Chernobyl nuclear explosion in the Ukraine. Most studies have focused on malignant diseases in children, specifically thyroid cancer and leukaemia. Authors of the review argue that there is good evidence to suggest that rates of thyroid cancer in children from the countries that were formally part of the Soviet Union have risen as a consequence of the Chernobyl accident. The findings for childhood leukaemia, they comment, are less conclusive. Among adult populations, there is no strong evidence to suggest that risk of thyroid cancer, leukaemia, or other malignant disease has increased as a result of the Chernobyl accident.
Hormone-replacement therapy (HRT) and breast cancer
HRT has been available for many years, but the important question of its place in development and progression of breast cancer remains controversial. This review summarises current clinical data, which suggest that short-term HRT use does not increase breast-cancer risk, although a small increase in risk is associated with long-term (more than 10 years) HRT use. The review highlights the need for prospective controlled trials in healthy women as well as those at higher risk of breast cancer or with a personal history of the disease.
A case for geriatric oncology
The increase in cancer incidence with increasing age is becoming more obvious and more important as the average age of the population increases. This review assesses the biological and clinical interactions of cancer and ageing and discusses the skills and knowledge necessary for caring for older patients.
A CULTURE OF MISTRUST
This month’s Leading Edge editorial examines the issues surrounding diet and cancer, especially media reports that often contradict each other; foodstuffs that are often touted as cancer preventives one week are later reported as harmful. The editorial discusses how data should be presented, analysed, and interpreted, and concludes that there is currently a culture of mistrust in which most people disbelieve the health risks associated with dietary advice.
Other Reviews:
Telomerase inhibition and the future management of head-and-neck cancer
Insulin-like growth factors and cancer
Scientists and clinicians test their metal-back to the future with platinum compounds
THE LANCET INFECTIOUS DISEASES (TLID)
DOES HEPATITIS C VIRUS CAUSE SEVERE LIVER DISEASE ONLY IN PEOPLE WHO DRINK ALCOHOL?
The authors of a review in this month’s TLID propose that hepatitis C virus, which infects 170 million people worldwide, rarely causes liver cirrhosis and liver cancer in the absence of alcohol consumption. Considerable money and effort has gone into finding drugs to treat hepatitis C, when abstinence from alcohol may be the most effective way of preventing disease progression.
AND THE WINNER IS….
This month’s leading edge editorial discusses the gap between the alleged benefits of new pharmaceuticals, often launched amid a fanfare of publicity boasting new therapeutic benefit, and the more objective judgement of independent commentators within the pharmaceutical media. The French drug bulletin la revue Prescrire, for example, critically reviews all new drug launches and operates an annual awards scheme for the best innovations in the therapeutics. Despite numerous high-profile drug launches, the coveted ‘golden pill’ was not awarded by Prescrire last year, and no drug has received top rating in the bulletin since 1996.
The editorial comments: ‘A substantial gap has clearly emerged between what the editors of Prescrire believe to be the quality of service patients should receive and the quality of service that the pharmaceutical industry can deliver. Anti-infectives seem to be as ill-served as any segment of the pharmaceutical market, and there is no reason to believe that the editors of Prescrire are alone in their opinions among independent commentators on therapeutics.’
Other Reviews:
Epidemiology of chronic hepatitis C virus infection in sub-Saharan Africa
Role of nitric oxide in HIV-1 infection: friend or foe?
Update on Kaposi’s sarcoma and other HHV8 associated diseases. Part 1: epidemiology, environmental predispositions, clinical manifestations, and therapy
Could a herpesvirus be the cause of Kawasaki disease?
Lancet
Thyroid Cancer News and Current Thyroid Cancer Events RSSResearchers discover atomic bomb effect results in adult-onset thyroid cancer
Radiation from the atomic bomb blasts in Hiroshima and Nagasaki, Japan, in 1945, likely rearranged chromosomes in some survivors who later developed papillary thyroid cancer as adults, according to Japanese researchers.
Scans spot hidden tumors in rare cancer syndrome
Researchers at Dana-Farber Cancer Institute report that full-body PET/CT scanning detected unsuspected, treatable tumors in 3 of 15 patients with Li-Fraumeni syndrome (LFS), a rare genetic cancer syndrome for which no screening tests have been recommended.
Mailman School PH study finds increase in thyroid diseases risk from exposure at Chernobyl
Persons exposed to radioactive fallout from the Chernobyl accident as children and adolescents have an increased risk of follicular adenoma or benign tumor of the thyroid gland, according to researchers at Columbia University Mailman School of Public Health.
Scientists solve structure of gene regulator that plays key role in cancer
Scientists at The Wistar Institute have collaborated on a major advance in understanding a gene regulator that contributes to some of the deadliest cancers in humans. The culmination of 10 years' work, their research paves the way for the development of new cancer therapies.
Presence of gene mutation helps guide thyroid cancer treatment
A specific gene mutation may be useful in predicting the level of aggression of thyroid cancer and help guide treatment options and follow-up care, according to new study findings.
Role of Thyroid Hormones in Slumber Under Investigation at Rutgers-Camden
While the thyroid has long been linked to metabolism, cutting-edge research underway at Rutgers University-Camden is investigating the possibility that thyroid hormones have an important role in sleep regulation.
Ethanol injection helps manage bone metastasis in thyroid cancer patients
Percutaneous ethanol injection (PEI)-an injection of ethanol (alcohol) through the skin directly into a bone tumor to kill cancer cells-may be a valuable ancillary treatment for thyroid cancer patients whose cancer has spread to the bone. Japanese researchers announced these findings during the 54th Annual Meeting of SNM, the world's largest society for molecular imaging and nuclear medicine.
Hepatitis C increases risk of non-Hodgkin lymphoma
Hepatitis C infection is associated with an increased risk of non-Hodgkin lymphoma (malignancy involving lymphatic tissue) of 20 percent to 30 percent, and a three-fold increase in the risk of another type of lymphoma, according to a study in the May 9 issue of JAMA.
Lung cancer rates higher among female nonsmokers than previously
Not all lung cancer is due to a lifetime of smoking cigarettes. Sometimes the diagnosis is a mystery, and the stigma surrounding the disease makes it hard for patients to talk about.
Thyroid cancer discovery points to new treatments, prevention
The actions of a mutated protein in cells linked to thyroid cancer have been uncovered by researchers at Queen's University.
More Thyroid Cancer News Articles
 | Breast Cancer and Iodine : How to Prevent and How to Survive Breast Cancer by Dr. David Derry M.D., Ph.D. This book is about cause, prevention and treatment of breast cancer. Breast cancer has two phases. The first one, from abnormal cells up to carcinoma in situ reverses with iodine. The second phase, invasion, is controlled by connective tissue thyroid... |
 | Thyroid Cancer: A Guide for Patients This book is a valuable and extensive source of information about thyroid cancer and is specifically written for the patient with thyroid cancer. However, family and friends of patients who have thyroid cancer will also find this book useful. The book discusses a wide spectrum of aspects about thyroid nodules and cancer. It is discusses the basics of the thyroid gland, the evaluation of... |
 | The Thyroid Cancer Book by M. Sara Rosenthal, Ph.D. Now in its second edition, the only consumer book on thyroid cancer in plain language, also contains a Low Iodine Cookbook. Recommended by Johns Hopkins Thyroid Tumor Center, The Thyroid Foundation of America, The American Foundation for Thyroid Patients, The Thyroid Foundation of Canada, CancerHelpUK, and thyroid cancer patients from both Thyca and... |
 | Thyroid Cancer by Alan Elias M.D. Thyroid cancer is a relatively uncommon cancer although its incidence is increasing particularly among women. Because of the slow pace of spread of differentiated thyroid cancers a one-size fits all approach to the management of patients with this cancer is to be avoided. In this brief outline of the various types of thyroid cancer and their treatment the author has attempted to provide the... |
 | The Purple Butterfly: Diary of a thyroid cancer patient by Susan Hibberd 'The Purple Butterfly' cameos a year in the life of a thyroid cancer patient. Restrained and sparsely written, it gives the reader a deep insight into the mind of someone who is balancing on the edge of hysteria, yet still feels an obligation to `put on a brave face'. A 'must-read' for anyone supporting a friend or relative through a serious illness - this book tells you what he or she never... |
 | Quick FACTS Thyroid Cancer (Quickfacts) by American Cancer Society What people need to know-right from the start-about their Thyroid cancer More than 1.3 million Americans will be diagnosed with various forms of cancer this year. They, their families, and their caregivers will all be seeking information about their specific cancer type. This guide from the experts at the American Cancer Society gives them what they need to know, right from the... |
 | Thyroid Cancer in Clinical Practice by I. Ross McDougall The book covers all aspects of thyroid cancer, including nodules, pathology, thyroid and whole-body scans, ultrasounds, and other nuclear medicine and radiological studies, as well as follow-up testing and prognosis. It tackles the treatment of differentiated thyroid cancer (the commonest variety) and all aspects of the management including surgery, the role and logistics of radioactive iodine... |
 | Package - The Thyroid Cancer Book and The Low Iodine Diet Cookbook by M. Sara Rosenthal, Norene Gilletz Get both books at a one low... |
 | The Genetics of Complex Thyroid Diseases The autoimmune thyroid diseases and familial thyroid cancers are the current target of molecular thyroid genetics. Unlike the situation in monogenic thyroid diseases, for which the molecular genetics has largely been clarified over the past 20 years, a methodological approach to these more complex forms of thyroid disease has not yet been well established. The determination of susceptibility... |
 | Practical Management of Thyroid Cancer: A Multidisciplinary Approach Written by a multidisciplinary team of experts involved in the development of standards and guidelines for its management in the USA, UK, Europe and Asia, the book contains succinct and knowledgeable summaries of the management of thyroid cancer. Every chapter describes a different aspect of care, and provides clear and detailed information about caring for patients with this group of tumors. ... |
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