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Printer Friendly Print THE LANCET ONCOLOGY (TLO) AND THE LANCET INFECTIOUS DISEASES (TLID)

THE LANCET ONCOLOGY (TLO) AND THE LANCET INFECTIOUS DISEASES (TLID)

May 01, 2002

THE LANCET ONCOLOGY (TLO)

CHERNOBYL, IONISING RADIATION EXPOSURE, AND CANCER RISK




The first review in this month’s TLO reviews the epidemiological evidence linking cancer incidence as a result of the 1986 Chernobyl nuclear explosion in the Ukraine. Most studies have focused on malignant diseases in children, specifically thyroid cancer and leukaemia. Authors of the review argue that there is good evidence to suggest that rates of thyroid cancer in children from the countries that were formally part of the Soviet Union have risen as a consequence of the Chernobyl accident. The findings for childhood leukaemia, they comment, are less conclusive. Among adult populations, there is no strong evidence to suggest that risk of thyroid cancer, leukaemia, or other malignant disease has increased as a result of the Chernobyl accident.

Hormone-replacement therapy (HRT) and breast cancer

HRT has been available for many years, but the important question of its place in development and progression of breast cancer remains controversial. This review summarises current clinical data, which suggest that short-term HRT use does not increase breast-cancer risk, although a small increase in risk is associated with long-term (more than 10 years) HRT use. The review highlights the need for prospective controlled trials in healthy women as well as those at higher risk of breast cancer or with a personal history of the disease.

A case for geriatric oncology

The increase in cancer incidence with increasing age is becoming more obvious and more important as the average age of the population increases. This review assesses the biological and clinical interactions of cancer and ageing and discusses the skills and knowledge necessary for caring for older patients.

A CULTURE OF MISTRUST

This month’s Leading Edge editorial examines the issues surrounding diet and cancer, especially media reports that often contradict each other; foodstuffs that are often touted as cancer preventives one week are later reported as harmful. The editorial discusses how data should be presented, analysed, and interpreted, and concludes that there is currently a culture of mistrust in which most people disbelieve the health risks associated with dietary advice.

Other Reviews:

Telomerase inhibition and the future management of head-and-neck cancer

Insulin-like growth factors and cancer

Scientists and clinicians test their metal-back to the future with platinum compounds

THE LANCET INFECTIOUS DISEASES (TLID)

DOES HEPATITIS C VIRUS CAUSE SEVERE LIVER DISEASE ONLY IN PEOPLE WHO DRINK ALCOHOL?

The authors of a review in this month’s TLID propose that hepatitis C virus, which infects 170 million people worldwide, rarely causes liver cirrhosis and liver cancer in the absence of alcohol consumption. Considerable money and effort has gone into finding drugs to treat hepatitis C, when abstinence from alcohol may be the most effective way of preventing disease progression.

AND THE WINNER IS….

This month’s leading edge editorial discusses the gap between the alleged benefits of new pharmaceuticals, often launched amid a fanfare of publicity boasting new therapeutic benefit, and the more objective judgement of independent commentators within the pharmaceutical media. The French drug bulletin la revue Prescrire, for example, critically reviews all new drug launches and operates an annual awards scheme for the best innovations in the therapeutics. Despite numerous high-profile drug launches, the coveted ‘golden pill’ was not awarded by Prescrire last year, and no drug has received top rating in the bulletin since 1996.

The editorial comments: ‘A substantial gap has clearly emerged between what the editors of Prescrire believe to be the quality of service patients should receive and the quality of service that the pharmaceutical industry can deliver. Anti-infectives seem to be as ill-served as any segment of the pharmaceutical market, and there is no reason to believe that the editors of Prescrire are alone in their opinions among independent commentators on therapeutics.’

Other Reviews:

Epidemiology of chronic hepatitis C virus infection in sub-Saharan Africa

Role of nitric oxide in HIV-1 infection: friend or foe?

Update on Kaposi’s sarcoma and other HHV8 associated diseases. Part 1: epidemiology, environmental predispositions, clinical manifestations, and therapy

Could a herpesvirus be the cause of Kawasaki disease?

Lancet



Related Thyroid Cancer Current Events and Thyroid Cancer News Articles Thyroid Cancer Current Events and Thyroid Cancer News RSS Thyroid Cancer Current Events and Thyroid Cancer News RSS
Newly revised guidelines for managing thyroid cancer published in Thyroid journal
The American Thyroid Association has released new, revised Management Guidelines for the diagnosis and treatment of patients with thyroid nodules and thyroid cancer.

Study examines complications of thyroid surgery in older patients
In a study of patients undergoing thyroid surgery performed by a single surgeon, older adults did not appear to have more complications than younger patients.

Thyroid surgery safe for older patients, study finds
Thyroid surgery is safe for older patients, say physicians who found only slight differences in rates of complications and hospital readmissions in a multi-year study.

Researchers pinpoint a new enemy for tumor-suppressor p53
Researchers at The University of Texas M. D. Anderson Cancer Center have identified a protein that marks the tumor suppressor p53 for destruction, providing a potential new avenue for restoring p53 in cancer cells.

Vandetanib shows clinical benefit when combined with docetaxel for lung cancer
When combined with standard chemotherapy, an international Phase III trial has shown that the oral targeted therapy vandetanib improves progression-free survival for patients with advanced non-small cell lung cancer.

First comprehensive guidelines for managing medullary thyroid carcinoma published in Thyroid journal
New guidelines designed to standardize and optimize the diagnosis, treatment, and monitoring of patients with Medullary Thyroid Carcinoma (MTC), an uncommon and challenging form of thyroid cancer, have been developed by the American Thyroid Association.

Drug that targets vasculature growth attacks aggressive thyroid cancer
A medication that helps stop the growth of new blood vessels has produced dramatic benefits for some patients with aggressive thyroid cancer, research from Mayo Clinic indicates.

Metastatic bone disease patients can walk in Lazarus' footsteps
Osteoplasty-a highly effective minimally invasive procedure to treat the painful effects of metastatic bone disease by injecting bone cement to support weakened bones-provides immediate and substantial pain relief, often presenting individuals who are suffering terribly with the miraculous so-called "Lazarus effect," according to researchers at the Society of Interventional Radiology's 34th Annual Scientific Meeting.

Mayo Clinic Researchers Find Experimental Therapy Turns on Tumor Suppressor Gene in Cancer Cells
Researchers at Mayo Clinic have found that the experimental drug they are testing to treat a deadly form of thyroid cancer turns on a powerful tumor suppressor capable of halting cell growth. Few other cancer drugs have this property, they say.

Molecular imaging enables earlier, individualized treatment of thyroid cancer
In a study to determine the diagnostic value of molecular imaging in nodal staging of patients with thyroid cancer, researchers were able for the first time to accurately distinguish between cancerous cells in regional lymph nodes and normal residual thyroid tissue directly after surgery.
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This book is a valuable and extensive source of information about thyroid cancer and is specifically written for the patient with thyroid cancer. However, family and friends of patients who have thyroid cancer will also find this book useful.

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by M. Sara Rosenthal; Ph.D. (Author)

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The Purple Butterfly: Diary of a thyroid cancer patient
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