 |
|
Nicorandil Could Improve Outcome For Angina Patients
April 10, 2002Results of a UK study in this week's issue of THE LANCET suggest that the antianginal drug nicorandil could reduce the risk of cardiovascular disease associated with angina.
Angina occurs in 10% of men aged older than 60 years in the UK (10-15 years later in women), and is a common underlying cause of coronary heart disease (CHD). Aspirin, angiotensin-converting-enzyme (ACE) inhibitors, and statins reduce the risk of cardiovascular events in subgroups of patients with stable angina; however, the effect of specific antianginal treatment in these patients is unknown. The antianginal drug nicorandil is thought to have cardioprotective properties in addition to its anti-ischaemic effects. Henry Dargie from the Western Infirmary, Glasgow, UK, and the Impact Of Nicorandil in Angina (IONA) investigators did a randomised trial to find out whether nicorandil could reduce the frequency of coronary events in men and women who had stable angina and additional risk factors for CHD.
5126 patients from 226 centres in the UK were randomly assigned 20 mg nicorandil twice daily or identical placebo in addition to standard antianginal therapy (b-blockers, calcium-channel blockers, or long-acting nitrates). Average follow-up time was 1.6 years.
15.5% of patients in the placebo group and 13.1% in the nicorandil group had a primary endpoint (death due to coronary heart disease, non-fatal heart attack, or unplanned hospital admission because of chest pain). The rate of acute coronary syndromes was 7.6% in the placebo group and 6.1% in the nicorandil group; the corresponding rates for all cardiovascular events were 17% and 14.7%, respectively.
An accompanying Commentary (p 1262) by Edward Lesnefsky from Louis Stokes Veterans Affairs Medical Center, Cleveland, USA, concludes: 'The results of IONA provide strong evidence that the cellular effectors of ischaemic preconditioning will continue to emerge as key therapeutic targets in the development of strategies to manage ischaemic heart disease.'
Lancet
15.5% of patients in the placebo group and 13.1% in the nicorandil group had a primary endpoint (death due to coronary heart disease, non-fatal heart attack, or unplanned hospital admission because of chest pain). The rate of acute coronary syndromes was 7.6% in the placebo group and 6.1% in the nicorandil group; the corresponding rates for all cardiovascular events were 17% and 14.7%, respectively.
An accompanying Commentary (p 1262) by Edward Lesnefsky from Louis Stokes Veterans Affairs Medical Center, Cleveland, USA, concludes: 'The results of IONA provide strong evidence that the cellular effectors of ischaemic preconditioning will continue to emerge as key therapeutic targets in the development of strategies to manage ischaemic heart disease.'
Lancet
Heart Disease Current Events and Heart Disease News RSSMultiple health concerns surface as winter, vitamin D deficiences arrive
A string of recent discoveries about the multiple health benefits of vitamin D has renewed interest in this multi-purpose nutrient, increased awareness of the huge numbers of people who are deficient in it, spurred research and even led to an appreciation of it as "nature's antibiotic."
Carvedilol shown to have unique characteristics among beta blockers
In a new study, researchers report that a class of heart medications called beta-blockers can have a helpful, or harmful, effect on the heart, depending on their molecular activity.
ESC to give talks on Diabetes in three cities in China
As a result of successful events organised last year, a second Joint Scientific Forum, organised by the European Society of Cardiology (ESC) and the European Association for the Study of Diabetes (EASD), two of the most respected professional medical organisations in Europe, will be held from 27-29 November at three venues across China - Beijing, Shanghai and Guangzhou.
Saving the single cysteine: new antioxidant system found
We've all read studies about the health benefits of having a life partner. The same thing is true at the molecular level, where amino acids known as cysteines are much more vulnerable to damage when single than when paired up with other cysteines.
Drug for erectile dysfunction improves heart function in young heart-disease patients
Heart function significantly improved in children and young adults with single-ventricle congenital heart disease who have had the Fontan operation following treatment with sildenafil, a drug used to treat erectile dysfunction and pulmonary hypertension, say researchers from The Children's Hospital of Philadelphia.
Study raises concerns about outdoor second-hand smoke
Indoor smoking bans have forced smokers at bars and restaurants onto outdoor patios, but a new University of Georgia study in collaboration with the Centers for Disease Control and Prevention suggests that these outdoor smoking areas might be creating a new health hazard.
Night Beat, Overtime and a Disrupted Sleep Pattern Can Harm Officers' Health
A police officer who works the night shift, typically from 8 p.m. to 4 a.m., already is at a disadvantage when it comes to getting a good "night's" sleep.
Your Own Stem Cells Can Treat Heart Disease
The largest national stem cell study for heart disease showed the first evidence that transplanting a potent form of adult stem cells into the heart muscle of subjects with severe angina results in less pain and an improved ability to walk. The transplant subjects also experienced fewer deaths than those who didn't receive stem cells.
Vitamin B niacin offers no extra benefit to statin therapy in seniors already diagnosed with CAD
The routine prescription of extended-release niacin, a B vitamin (1,500 milligrams daily), in combination with traditional cholesterol-lowering therapy offers no extra benefit in correcting arterial narrowing and diminishing plaque buildup in seniors who already have coronary artery disease, a new vascular imaging study from Johns Hopkins experts shows.
Heart and bone damage from low vitamin D tied to declines in sex hormones
Researchers at Johns Hopkins are reporting what is believed to be the first conclusive evidence in men that the long-term ill effects of vitamin D deficiency are amplified by lower levels of the key sex hormone estrogen, but not testosterone.
More Heart Disease Current Events and Heart Disease News Articles
 |
Prevent and Reverse Heart Disease: The Revolutionary, Scientifically Proven, Nutrition-Based Cure by Caldwell B. Esselstyn (Author) A powerful call for a paradigm shift in heart disease therapy. Based on the groundbreaking results of a twenty-year nutritional study by Dr. Esselstyn, a preeminent researcher and clinician, this book illustrates that a plant-based, oil-free diet can not only prevent and stop the progression of heart disease but can also reverse its effects. The proof lies in the incredible outcomes for patients who have followed Dr. Esselstyn's program, including a number of patients in his original study who had been told by their cardiologists that they had less than a year to live. Within months of starting the program, Dr. Esselstyn's patients began to improve dramatically, and twenty years later, they remain free of symptoms. Complete with more than 150 delicious recipes, this book explains the... |
 |
Reverse Heart Disease Now: Stop Deadly Cardiovascular Plaque Before It's Too Late by Sinatra (Author), James C. Roberts M.D. (Author), Martin Zucker (Contributor) While most books focus solely on the role of cholesterol in heart disease, Reverse Heart Disease Now draws on new research that points to the surprising other causes. Two leading cardiologists draw on their collective fifty years of clinical cardiology research to show you how to combine the benefits of modern medicine, over-the-counter vitamins and supplements, and simple lifestyle changes to have a healthy heart. |
 |
Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, Single Volume (Heart Disease (Braunwald) (Single Vol)) by Peter Libby MD (Author), Robert O. Bonow MD (Author), Douglas L. Mann MD FACC (Author), Douglas P. Zipes MD (Author) Dr. Braunwald's masterwork returns ... bringing you the definitive guidance you need to overcome any challenge in clinical cardiology today, using the best approaches available! Hundreds of world authorities, many of them new to this edition, synthesize all of the recent developments that are revolutionizing practice - from the newest findings in molecular biology and genetics to the latest imaging modalities, interventional procedures, and medications. The expertise of the book's contributors, the scope of its coverage, and its richly illustrated, user-friendly format all make this the ultimate reference for the practicing cardiologist. Locate the answers you need fast, thanks to a user-friendly, full-color design, complete with more than 1,500 color illustrations.Glean clinically... |
 |
The First Year: Heart Disease: An Essential Guide for the Newly Diagnosed by Lawrence D. Chilnick (Author) By the co-creator of the New York Times-bestselling The Pill Book--key medical, diet, and lifestyle strategies for managing cardiovascular disease in the year post-diagnosis. Heart disease is the nation's leading health crisis, affecting more than 25.6 million Americans and causing 650,000 deaths each year. A longtime health editor, Lawrence Chilnick was stunned when he suffered a heart attack at age 48--but assumed his medications would take care of the condition. They didn't. Five years later, Chilnick needed a quadruple bypass. At that point, he set out to turn his life around by educating himself on all aspects of this life-threatening disease. Now, in this major addition to the bestselling The First Year® series (over 250,000 copies sold), Chilnick shares his story... |
 |
The Hidden Epidemic: Heart Disease in America Starring: Artist Not Provided Dramatic personal stories showcase the stunning scientific advances that are transforming the field of cardiology, and the effect these changes will have on people stricken with the disease. |
 |
Take a Load off Your Heart: 109 Things You Can Actually Do to Prevent, Halt and Reverse Heart Disease by Joseph C. Piscatella (Author), Barry A. Franklin (Author) Increase the odds of living longer with this bold, broad approach to cardiac health. A medically up-to-the-minute and easy-to-implement program, TAKE A LOAD OFF YOUR HEART sets our four key steps to cardiovascular fitness, from assessing risk to managing stress, from improving diet to making a habit of exercise. It demystifies predictive markers such as trigylcerides and Syndrome X, and offers 109 simple, practical lifestyle tips - #22 Breathe deeply, #96 Drink black tea, #3 Increase your HDL level, #54 Walk briskly, #75 Give up dieting - for preventing, stabilizing and, yes, reversing heart disease. |
 |
American Medical Association Guide to Preventing and Treating Heart Disease: Essential Information You and Your Family Need to Know about Having a Healthy Heart by American Medical Association (Author), Martin S. Lipsky MD (Author), Marla Mendelson (Author), Stephen Havas MD MPH (Author), Michael Miller MD (Author) More Than 3 Million American Medical Association Books Sold. American's most trusted medical authority shows you how to prevent and treat heart disease. When you or someone you love is diagnosed with cardiovascular disease, it's important to know the facts, which can help save a life. In the American Medical Association Guide to Preventing and Treating Heart Disease, you will learn everything you need to know about heart disease to ensure a long, full, and active life. Authoritative and up to date, the American Medical Association Guide to Preventing and Treating Heart Disease explains the most common forms of heart and blood vessel disease and lays out practical strategies to get you on the road to better health. The book also provides... |
 |
Heart Disease for Dummies by James M. Rippe M.D. (Author) A leading cardiologist explains how to reverse, treat, and prevent heart disease Over 61 million Americans have been diagnosed with some form of cardiovascular disease. Now, leading cardiologist Dr. James Rippe delivers the scoop on the many different forms of heart disease (including angina, heart attacks, arrhythmias, strokes, heart failure, and other cardiac conditions) as well as the latest research, diagnostic techniques, treatment procedures, and medications. Readers will find sound, practical advice on how to prevent and reverse heart disease through diet, stress reduction, exercise, and much more. James M. Rippe, MD (Shrewsbury, MA), a renowned cardiologist and authority on preventive care, is the founder and Director of the Center for Clinical and Lifestyle Research and... |
 |
Health Matters: What You Need to Know About Cancer, Heart Disease, Depression, and Obesity Starring: Health Matters: What You Need to Know About Cancer, Heart Disease, Depression, and Obesity Directed By: various |
 |
Dr. Dean Ornish's Program for Reversing Heart Disease: The Only System Scientifically Proven to Reverse Heart Disease Without Drugs or Surgery by Dean Ornish (Author) Dr. Dean Ornish is the first clinician to offer documented proof that heart disease can be halted, or even reversed, simply by changing your lifestyle. Based on his internationally acclaimed scientific study, which has now been ongoing for years, Dr. Ornish's program has yielded amazing results. Participants reduced or discontinued medications; their chest pain diminished or disappeared; they felt more energetic, happy, and calm; they lost weight while eating more; and blockages in coronary arteries were actually reduced. In his breakthrough book, Dr. Ornish presents this and other dramatic evidence and guides you, step-by-step, through the extraordinary Opening Your Heart program, which is winning landmark approval from America's health insurers. The program takes you beyond the... |
| © 2009 BrightSurf.com |