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Modest Survival Benefit From Chemotherapy For Patients With Glioma Brain Tumours (p 1011)
March 20, 2002Chemotherapy in addition to radiotherapy could have a modest survival benefit for the treatment of high-grade glioma, a severe form of brain cancer, conclude authors of a study in this week's issue of THE LANCET.
Malignant gliomas are among the most devastating of cancers. They frequently result in profound and progressive disability, which often leads to death. Average survival time is only around nine months, with a two-year survival of around 5-10%. Conventional treatment includes resection and radiotherapy; previous studies about the effect of systemic chemotherapy on survival and recurrence in adult patients with high-grade glioma have had inconclusive results.
Lesley Stewart and colleagues from the MRC Clinical Trials Unit, London, UK, did a systematic review and meta-analysis using updated data on individual patients from all available randomised trials that compared radiotherapy alone with radiotherapy combined with chemotherapy. Data on around 3000 patients from 12 randomised controlled trials were included.
Patients given chemotherapy in addition to radiotherapy had a modest (6%) increase in one-year survival compared with patients only given radiotherapy (46% versus 40%, respectively). Patients given chemotherapy also had a two-month increase in average survival time.
Lesley Stewart comments: "The clear effect observed in this comprehensive review does show that high-grade gliomas can respond to chemotherapy and that further research into newer chemotherapies and methods of delivery is justified. The size of the benefit and remaining uncertainty about quality of life mean that some health professionals would consider radiotherapy alone to be a justified standard therapy, whereas others might believe that the appropriate standard therapy should now include a nitrosourea [class of chemotherapeutic agent]. Both camps are likely to agree that the small but clear improvement in survival from chemotherapy encourages further study of drug treatment of these tumours."
Lancet
Patients given chemotherapy in addition to radiotherapy had a modest (6%) increase in one-year survival compared with patients only given radiotherapy (46% versus 40%, respectively). Patients given chemotherapy also had a two-month increase in average survival time.
Lesley Stewart comments: "The clear effect observed in this comprehensive review does show that high-grade gliomas can respond to chemotherapy and that further research into newer chemotherapies and methods of delivery is justified. The size of the benefit and remaining uncertainty about quality of life mean that some health professionals would consider radiotherapy alone to be a justified standard therapy, whereas others might believe that the appropriate standard therapy should now include a nitrosourea [class of chemotherapeutic agent]. Both camps are likely to agree that the small but clear improvement in survival from chemotherapy encourages further study of drug treatment of these tumours."
Lancet
Chemotherapy Current Events and Chemotherapy News RSS1930s drug slows tumor growth
Drugs sometimes have beneficial side effects. A glaucoma treatment causes luscious eyelashes. A blood pressure drug also aids those with a rare genetic disease.
First use of antibody and stem cell transplantation to successfully treat advanced leukemia
For the first time, researchers at Fred Hutchinson Cancer Research Center have reported the use of a radiolabeled antibody to deliver targeted doses of radiation, followed by a stem cell transplant, to successfully treat a group of leukemia and pre-leukemia patients for whom there previously had been no other curative treatment options.
New Synthetic Molecules Trigger Immune Response to HIV and Prostate Cancer
Researchers at Yale University have developed synthetic molecules capable of enhancing the body's immune response to HIV and HIV-infected cells, as well as to prostate cancer cells. Their findings, published online in the Journal of the American Chemical Society, could lead to novel therapeutic approaches for these diseases.
Chemo-radiation before prostate removal may prevent cancer recurrence
Researchers in the Oregon Health & Science University Knight Cancer Institute and the Portland Veterans Affairs Medical Center have found a combination of radiation therapy and chemotherapy given before prostate removal is safe and may have the potential to reduce cancer recurrence and improve patient survival.
PMH finding may help some tonsil cancer patients avoid chemotherapy
Clinical researchers at Princess Margaret Hospital (PMH) have confirmed that patients with oropharyngeal squamous cell cancer ("tonsil cancer") harbour a common type of human papilloma virus (HPV16), but also that such cancers are very sensitive to radiation.
Study of concurrent radiotherapy, chemotherapy shows promise in small cell lung cancer
Treating limited stage small cell lung cancer(LSCL) with a combination of accelerated high-dose radiotherapy and chemotherapy has shown encouraging results.
Blood vessels might predict prostate cancer behavior
A diagnosis of prostate cancer raises the question for patients and their physicians as to how the tumor will behave. Will it grow quickly and aggressively and require continuous treatment, or slowly, allowing therapy and its risks to be safely delayed?
Discovery offers potential new pancreatic cancer treatment
Tiny particles that can carry drugs and target cancer cells may offer treatment hope for those suffering with pancreatic cancer. New research to be presented in November at the American Association of Pharmaceutical Scientists (AAPS) Annual Meeting in Los Angeles reveals that tumor-penetrating microparticles (TPM) have been specifically designed to break through hard-to-infiltrate barriers and deliver drugs more effectively and efficiently than the standard form of chemotherapy such as those injected through a vein.
Early-stage, HER2-positive breast cancer patients at increased risk of recurrence
Early-stage breast cancer patients with HER2 positive tumors one centimeter or smaller are at significant risk of recurrence of their disease, compared to those with early-stage disease who do not express the aggressive protein, according to a study led by researchers at The University of Texas M. D. Anderson Cancer Center.
An exquisite container
In campy old movies, Lucretia Borgia swans around emptying powder from her ring into wine glasses carelessly left unattended. The poison ring is usually a confection of gold filigree holding a cabochon or faceted gemstone that can be broken to empty the ring's contents. It is invariably enormous - so large it is rather odd nobody seems to notice it.
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