 |
|
UAB Researchers Discover a New Mechanism Involved in Predisposition to Cancer
February 26, 2002A team of researchers at the Universitat Autònoma de Barcelona (UAB) has discovered a new mechanism that accelerates the shortening of telomeres (structures that protect the ends of chromosomes) involved in genetic instability and a predisposition to cancer. The research has been published in the journal Human Molecular Genetics.
DNA in higher organisms is organised into individual chromosomes, the ends of which are protected by structures called telomeres. Telomeres are very important in maintaining the cells’ genetic integrity, as they prevent the chromosomes from joining together, protect their ends from degradation and are involved in segregating chromosomes properly during cellular division. They also play a decisive role in two fields that are very important in social and biological terms: cancer and ageing. Telomeres gradually shorten and thus indicate the point at which the cell dies and control the proper proliferation of tissues.
For the first time, a team of researchers at the Universitat Autònoma de Barcelona has observed that telomeres may shorten more quickly due to sudden breakages in the DNA sequence that they consist of. The scientists made this discovery by analysing cells from a genetic syndrome called Fanconi’s anaemia, which is typified by a high genetic instability and chromosomal fragility, and which causes a very high predisposition to contracting cancer in harbourers (a risk of leukaemia 15,000 times higher than in a healthy person). The researchers have observed that the telomeres of affected patients present an accelerated shortening owing to breakages in the telomeric DNA sequence, leading to chromosomes being unprotected and joining together. This mechanism may explain patients’ symtomatology and their tendency to contract cancer. The research thus provides a first experimental link between a predisposition to cancer with the mechanism of sudden shortening of telomeres.
Fanconi’s anaemia came to public notice a little over a year ago (4th October 2000) when the parents of a patient (Molly Nash) genetically selected an embryo so that the newborn baby could become a donor of histocompatible blood for a bone marrow transplant to the infant’s elder sibling.
The interdisciplinary research has been published in Human Molecular Genetics, one of the most prestigious journals on human genetics, and was carried out by the Research Fellow Elsa Callén, under the supervision of Dr. Jordi Surrallés, the Mutagenesis Group “Ram'�n y Cajal” Researcher in the genetics and Microbiology Department of the UAB, in co-operation with the Spanish National Biotechnology Centre, the Vall d’Hebron Hospital and the Hospital de la Santa Creu i Sant Pau in Barcelona. The study was carried out within the framework of a scientific collaboration agreement between the UAB and the Fanconi Anaemia Research Fund, Inc. in Oregon (USA) and was supported by the Ministry of Health and Consumption Fund for Health Research.
Barcelona, Universitat Aut�noma de
Fanconi’s anaemia came to public notice a little over a year ago (4th October 2000) when the parents of a patient (Molly Nash) genetically selected an embryo so that the newborn baby could become a donor of histocompatible blood for a bone marrow transplant to the infant’s elder sibling.
The interdisciplinary research has been published in Human Molecular Genetics, one of the most prestigious journals on human genetics, and was carried out by the Research Fellow Elsa Callén, under the supervision of Dr. Jordi Surrallés, the Mutagenesis Group “Ram'�n y Cajal” Researcher in the genetics and Microbiology Department of the UAB, in co-operation with the Spanish National Biotechnology Centre, the Vall d’Hebron Hospital and the Hospital de la Santa Creu i Sant Pau in Barcelona. The study was carried out within the framework of a scientific collaboration agreement between the UAB and the Fanconi Anaemia Research Fund, Inc. in Oregon (USA) and was supported by the Ministry of Health and Consumption Fund for Health Research.
Barcelona, Universitat Aut�noma de
Cancer Current Events and Cancer News RSSMenopause-cardiology consensus statement on cardiovascular disease and on HRT
A menopause-cardiology consensus statement has called for direct action to prevent cardiovascular disease (CVD) in menopausal women. The statement also concludes that there is little evidence of increased CVD risk in taking HRT.
Other Illnesses, Body Weight Do Not Explain Racial Disparities in Colon Cancer Survival, UAB Researchers Say
A new study by University of Alabama at Birmingham (UAB) researchers shows that body-mass index (BMI) and co-existing medical conditions (co-morbidity) do not explain the decreased survival observed among African-Americans compared to Caucasians who also have colon cancer.
Multiple health concerns surface as winter, vitamin D deficiences arrive
A string of recent discoveries about the multiple health benefits of vitamin D has renewed interest in this multi-purpose nutrient, increased awareness of the huge numbers of people who are deficient in it, spurred research and even led to an appreciation of it as "nature's antibiotic."
AIDS research reveals a lack of family-planning programs in Uganda
University of Alberta graduate student Jennifer Heys wants to make her message clear: there needs to be more education in Ugandan communities about contraception.
Possible Link Studied Between Childhood Abuse and Early Cellular Aging
Children who suffer physical or emotional abuse may be faced with accelerated cellular aging as adults, according to new research from Butler Hospital and Brown University.
Rare pancreatic cancer patients may live longer when treated with radiation therapy
Radiation therapy is effective in achieving local control and palliation in patients with pancreatic neuroendocrine tumors (PNTs), despite such tumors being commonly considered resistant to radiation therapy.
Researchers Identify Role of Gene in Tumor Development, Growth and Progression
Virginia Commonwealth University Massey Cancer Center and VCU Institute of Molecular Medicine researchers have identified a gene that may play a pivotal role in two processes that are essential for tumor development, growth and progression to metastasis.
Saving the single cysteine: new antioxidant system found
We've all read studies about the health benefits of having a life partner. The same thing is true at the molecular level, where amino acids known as cysteines are much more vulnerable to damage when single than when paired up with other cysteines.
Gene mismatch influences success of bone marrow transplants
A commonly inherited gene deletion can increase the likelihood of immune complications following bone marrow transplantation, an international team of researchers reports in the November 22 advance online issue of Nature Genetics.
Cancer metabolism discovery uncovers new role of IDH1 gene mutation in brain cancer
Agios Pharmaceuticals today announced that its scientists have established, for the first time, that the mutated IDH1 gene has a novel enzyme activity consistent with a cancer-causing gene, or oncogene.
More Cancer Current Events and Cancer News Articles
 |
Anticancer: A New Way of Life (Thorndike Nonfiction) by David Servan-Schreiber (Author) The New York Times bestseller takes us on an empowering journey and changes the way we think about fighting cancer David Servan-Schreiber's story of his journey from cancer patient to health combines memoir with a clear scientific explanation of what makes cancer cells thrive and what inhibits them. Anticancer is filled with easy to understand charts and diagrams and a sixteen-page color "Anticancer Action" insert that enables readers to make small but essential changes in lifestyle and diet. Your body knows how to fight cancer, says Servan-Schreiber, and you have to help it with nutrition, physical exercise, stress management, and avoiding environmental toxins. Anticancer enables people living with cancer to adopt a proactive attitude to living, even thriving, with cancer and... |
 |
Cancer: 50 Essential Things to Do: Third Edition by Greg Anderson (Author) The ground-breaking classic guide to surviving cancer—now completely updated! Revised and updated for the first time since 1999, this invaluable guide to cancer recovery offers an easily accessible plan for patients and family members. Written by a cancer survivor, the book is an inspiring, action-oriented roadmap for those who choose to adopt a stance of hope and take charge of their diagnosis. With penetrating insights that bring together more than two decades of scientifically supported research and experience, Anderson reveals a step-by-step holistic action plan that has been successfully employed by hundreds of thousands of cancer patients worldwide. Anderson’s message is: “You must not simply treat illness, you must also create wellness—physically,... |
 |
Beating Cancer with Nutrition, book with CD by Patrick Quillin (Author) Beating Cancer with Nutrition. Sugar feeds Cancer: diet and supplements can starve tumors· Nutrition makes chemo and radiation more toxic to the tumor while protecting the patient. Nutrition changes underlying causes of cancer, improving outcome for cancer patients regardless of other therapies. Why Beating Cancer with Nutrition is unique: The book was developed after working with over 500 cancer patients and organizing 3 international symposiums on the subject. The information contained in BCN is both scientifically backed with references and clinically proven in the hospital with patients. This information helps cancer patients to improve quality and quantity of life. BCN had been translated into Japanese and Chinese and is being translated into Korean. BCN had become a home study... |
|
Wildfox The Cancer Tee,T-shirts for Women, One Size,White by Wildfox Wildfox The Cancer Tee,T-shirts for Women: One Size Fits Most Oversized loose-fit tee with screen print on front; 100% cotton. By Wildfox | |
 |
The Biology of Cancer HB by Robert A. Weinberg (Author) The Biology of Cancer is a new textbook for undergraduate and graduate biology students as well as medical students studying the molecular and cellular bases of cancer. The book presents the principles of cancer biology in an organized, cogent, and in-depth manner. The clarity of writing and the lucid full-color art program make the book accessible and engaging. The information unfolds through the presentation of key experiments which give readers a sense of discovery and provides insights into the conceptual foundation underlying modern cancer biology. The Biology of Cancer synthesizes the findings of three decades of recent cancer research and proposes a conceptual framework from which to teach about these discoveries. It provides the necessary structure, organization, and... |
 |
Cancer: Step Outside the Box by Ty M. Bollinger (Author) “My hat’s off to this author. What an informative, thorough, accurate life-saving read. It's all there - just bring your highlighter and prepare to be enlightened” says Pam Hoeppner, breast cancer survivor who cured her cancer using Protocel, a treatment outlined in this book. With satisfied readers in over 50 countries world wide, Ty Bollinger’s “Cancer: Step Outside the Box” is a roadmap to successfully treating cancer and regaining your health! The fourth edition, published in May of 2009, is chock full of the most effective, non-toxic cancer treatments in the world. Truth be told, there are many potent and well-proven alternative strategies for preventing and treating cancer... without surgery, chemotherapy, or radiation (the “Big 3”). Inside this... |
 |
What to Eat if You Have Cancer (revised): Healing Foods that Boost Your Immune System by Maureen Keane (Author), Daniella Chace (Author) Fuel your body to fight cancer Cancer and cancer treatment take a toll on your body, but you can help make cancer treatment more effective and reduce its unpleasant side effects with good nutrition. What to Eat if You Have Cancer presents the best foods to fight cancer and suggests ways to keep your body strong--knowledge you need to take control of your health. A vital resource for cancer patients, this revised edition contains new recipes, new menus, and the latest research on cancer and nutrition. With the help of What to Eat if You Have Cancer, you will learn The foods to eat and the foods to avoid in your fight with cancer The proper use of supplements in nutrition therapy How to create personalized meal plans to... |
 |
When Someone You Love Has Cancer: A Guide to Help Kids Cope (Elf-Help Books for Kids) by Alaric Lewis (Author), R. W. Alley (Illustrator) |
![10 Pack of i[2]y Stupid Cancer Wristbands](http://ecx.images-amazon.com/images/I/31ru5i5U21L._SL160_.jpg) |
10 Pack of i[2]y Stupid Cancer Wristbands by I'm Too Young For This! Cancer Foundation Show your support for i[2]y and the Stupid Cancer Movement by Giving Cancer the Bird. Seventy thousand Americans between 15 and 39 years old are diagnosed with cancer every year one every eight minutes. Unlike every other age group, there has been no improvement in 5-year survival rates for young adults in the past 30 years. This is not OK! It's time for survivors in their teens, 20s and 30s to have their voices heard. Give cancer the bird and join the fight for the next generation of survivors. Stupid Cancer! Survivors Rule! 100% of all proceeds benefit the I'm Too Young For This! Cancer Foundation and it's life saving mission to support young adults with stupid cancer. i[2]y Stupid Cancer Wristbands come in packs of 10 wristbands so you and your friends can spread the word. |
 |
Cancer-Free: Your Guide to Gentle, Non-toxic Healing (Third Edition) by Bill Henderson (Author) "If you love your stricken one, this is your Bible." said Denzel Koh of Brisbane, Australia after he healed his daughter's cancer using the information in a previous edition of this book. A cancer diagnosis always causes fear. All of us have seen relatives and friends destroyed by conventional cancer treatment. Now, thanks to books like this one and the Internet, you can quickly learn what you need to know. You can heal the cancer using natural, non-toxic substances that work. What you need is a guide to cut through the overwhelming jungle of information. This book provides that guide. The information in it has been refined over eight years using feedback from real cancer survivors about what worked for them. The author has counseled hundreds of cancer... |
| © 2009 BrightSurf.com |