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No link between asthma inhalers and hyperactivity in preschool children
February 18, 2002The widely held parental belief that asthma inhalers cause hyperactivity in children is not confirmed by research published in the Archives of Disease in Childhood.
The researchers studied 19 asthmatic children between the ages of 2 and 5, all of whom were treated with fast acting reliever inhalers/nebulisers containing salbutamol. The children were being seen at the children’s respiratory clinic at Guy’s and St Thomas’ Hospital, London.
Before being tested, the children’s hyperactivity levels were scored on a specially devised rating scale and the parents were asked about salbutamol’s effect on their children. The researchers then tested the children twice, giving them either salbutamol or a dummy drug (placebo), and vice versa. Play sessions were held before and after the children had been given salbutamol during which activity levels were scored.
Without exception, all the parents believed their children became hyperactive after inhaling salbutamol, but their ratings of the children’s activity levels were the same before and after inhaling salbutamol. And there was no observed difference in the children’s behaviour.
The authors suggest that perhaps repeated doses of salbutamol are required to produce hyperactivity. Alternatively, they suggest that the circumstances in which salbutamol is given - during an attack and at home - may alter the child’s response and affect the observations of their parents.
British Medical Journal (BMJ)
Without exception, all the parents believed their children became hyperactive after inhaling salbutamol, but their ratings of the children’s activity levels were the same before and after inhaling salbutamol. And there was no observed difference in the children’s behaviour.
The authors suggest that perhaps repeated doses of salbutamol are required to produce hyperactivity. Alternatively, they suggest that the circumstances in which salbutamol is given - during an attack and at home - may alter the child’s response and affect the observations of their parents.
British Medical Journal (BMJ)
Asthma Current Events and Asthma News RSSExposures to metals and diesel emissions in air linked to respiratory symptoms in children
Exposure shortly after birth to ambient metals from residential heating oil combustion and particles from diesel emissions are associated with respiratory symptoms in young inner city children.
Exposure to both traffic, indoor pollutants puts some kids at higher risk for asthma later
New research presents strong evidence that the "synergistic" effect of early-life exposure to both outdoor traffic-related pollution and indoor endotoxin causes more harm to developing lungs than one or the other exposure alone.
Johns Hopkins researchers track down protein responsible for chronic rhinosinusitis with polyps
A protein known to stimulate blood vessel growth has now been found to be responsible for the cell overgrowth in the development of polyps that characterize one of the most severe forms of sinusitis, a study by Johns Hopkins researchers suggests.
Ancestry attracts, but love is blind
People preferentially marry those with similar ancestry, but their decisions are not necessarily based on hair, eye or skin colour.
Common plastics chemicals linked to ADHD symptoms
Phthalates are important components of many consumer products, including toys, cleaning materials, plastics, and personal care items.
Asthma a significant risk factor for complications in children with H1N1
A new study on pediatric H1N1 influenza admissions has found that asthma is a significant risk factor for severe disease in children with pandemic H1N1 compared with the seasonal flu.
Mother's Depression a Risk Factor in Childhood Asthma Symptoms, Study Suggests
Asthma symptoms can worsen in children with depressed mothers, according to research from Johns Hopkins Children's Center published online in the Journal of Pediatric Psychology.
Sweet -- sugared polymer a new weapon against allergies and asthma
Scientists at Johns Hopkins and their colleagues have developed sugar-coated polymer strands that selectively kill off cells involved in triggering aggressive allergy and asthma attacks.
Pivotal study for PSD502 -- the first potential treatment for premature ejaculation
At the annual meeting of the Sexual Medicine Society of North America (SMSNA), Inc. in San Diego, Sciele Pharma, Inc., a Shionogi Company and Plethora Solutions Limited, a wholly owned subsidiary of Plethora Solutions Holdings PLC ("Plethora" - AIM:PLE)., today presented data from its second positive pivotal study of PSD502 for the treatment of premature ejaculation (PE).
Aileron collaborates study in Nature: Stapled peptides inhibit Notch1 transcription factor
This research validates the potential for Stapled Peptides to modulate key intracellular biological targets, such as transcription factors, that have not been addressable with current small molecule or biologic drug modalities.
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