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Genes are of little importance in rheumatoid arthritis
January 30, 2002Genes are of little importance in the development of rheumatoid arthritis, finds a study in this week's BMJ.
Researchers in Denmark surveyed over 37,000 twins about rheumatic diseases. Twin studies are one of the simplest ways to unravel the relative importance of genetic and environmental effects of a disease. Twins who reported that they had rheumatoid arthritis were invited to have a clinical examination.
Rheumatoid arthritis was verified in 13 identical and 36 non-identical twins. No identical twins and only two pairs of non-identical twins both had rheumatoid arthritis, suggesting that rheumatoid arthritis is no more common in identical twins than non-identical twins.
Despite some study limitations, the authors conclude that environmental effects may be more important than genetic effects in the development of rheumatoid arthritis.
This study cannot disprove a genetic component in susceptability to rheumatoid arthritis, writes Professor Alan Silman in an accompanying commentary. However, the results emphasise that the genetic effects are weak compared with environmental ones in explaining differences in occurrence of disease.
British Medical Journal (BMJ)
Despite some study limitations, the authors conclude that environmental effects may be more important than genetic effects in the development of rheumatoid arthritis.
This study cannot disprove a genetic component in susceptability to rheumatoid arthritis, writes Professor Alan Silman in an accompanying commentary. However, the results emphasise that the genetic effects are weak compared with environmental ones in explaining differences in occurrence of disease.
British Medical Journal (BMJ)
Arthritis Current Events and Arthritis News RSSCan EP4 agonist alleviate gastric lesions?
Over 300 million patients use non-steroidal anti-inflammatory drugs (NSAIDs) in the world to treat pain, arthritis, fever and other diseases. Nearly 30% of the users suffer from gastric lesions and bleeding.
Thoughtful words help couples stay fighting fit
Couples who bring thoughtful words to a fight release lower amounts of stress-related proteins, suggesting that rational communication between partners can ease the impact of marital conflict on the immune system.
Penn Study Provides First Clear Idea of How Rare Bone Disease Progresses
An international team of scientists, led by researchers at the University of Pennsylvania School of Medicine, is taking the first step in developing a treatment for a rare genetic disorder called fibrodysplasia ossificans progressiva (FOP), in which the body's skeletal muscles and soft connective tissue turns to bone, immobilizing patients over a lifetime with a second skeleton.
Aileron collaborates study in Nature: Stapled peptides inhibit Notch1 transcription factor
This research validates the potential for Stapled Peptides to modulate key intracellular biological targets, such as transcription factors, that have not been addressable with current small molecule or biologic drug modalities.
Researchers find new way to attack inflammation in Graves' eye disease
A small group of patients with severe Graves' eye disease experienced rapid improvement of their symptoms - and improved vision - following treatment with the drug rituximab.
Common Pain Relievers May Dilute Power of Flu Shots
With flu vaccination season in full swing, research from the University of Rochester Medical Center cautions that use of many common pain killers - Advil, Tylenol, aspirin - at the time of injection may blunt the effect of the shot and have a negative effect on the immune system.
Mending meniscals in children, improving diagnosis and recovery
The meniscus is a rubber-like, crescent moon-shaped cartilage cushion that sits between the leg and thigh bone. Each knee has two menisci: one on the inside of the knee joint and one on the outside.
Study finds link between childhood physical abuse and arthritis
Adults who had experienced physical abuse as children have 56 per cent higher odds of osteoarthritis compared to those who have not been abused, according to a new study by University of Toronto researchers.
Pain thresholds linked to inflammation and sleep problems in arthritis patients
Despite recent advances in anti-inflammatory therapy, many rheumatoid arthritis (RA) patients continue to suffer from pain.
URI research couple's method targets cancerous tumors
Two University of Rhode Island associate professors, biophysicists Yana Reshetnyak and Oleg Andreev, have discovered a technology that can detect cancerous tumors and deliver treatment to them without the harming the healthy cells surrounding them, thereby significantly reducing side effects.
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