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High doses of folic acid may help to prevent stomach cancer
December 17, 2001High doses of folic acid may help to prevent digestive tract cancers, suggests animal research reported in Gut.
A cancer inducing chemical was given to 16 dogs for eight months. And for 15 months, half the animals were also treated with 20 mg of folic acid, levels that are much higher than would be expected from diet alone. Tissue samples were taken from the gut wall every two to three months.
All eight dogs given the cancer inducing chemical alone developed stomach cancer; only three of the dogs treated with folic acid did so. Furthermore, 15 months after the experiment, circulating and gastric tissue levels of folate were still very high in the dogs given this supplement.
Folate deficiency can upset body chemistry and activate substances called proto-oncogenes, which are known to initiate and promote the development of cancer. Folate is also essential for normal DNA growth and repair.
Rich sources of folate include green leafy vegetables and legumes. The authors say that a folate intake of 400g/day, largely obtained from dietary sources, usually prevents folate deficiency, but that higher doses might need to be obtained from supplements.
Further research is needed, conclude the authors, but they suggest that the results may be applicable to human gastric cancers, and that folate could be used to prevent the development of digestive tract cancers.
British Medical Journal (BMJ)
Folate deficiency can upset body chemistry and activate substances called proto-oncogenes, which are known to initiate and promote the development of cancer. Folate is also essential for normal DNA growth and repair.
Rich sources of folate include green leafy vegetables and legumes. The authors say that a folate intake of 400g/day, largely obtained from dietary sources, usually prevents folate deficiency, but that higher doses might need to be obtained from supplements.
Further research is needed, conclude the authors, but they suggest that the results may be applicable to human gastric cancers, and that folate could be used to prevent the development of digestive tract cancers.
British Medical Journal (BMJ)
Cancer Current Events and Cancer News RSSTobacco smuggling is killing more people than illegal drugs
Tobacco smuggling causes around 4,000 premature deaths a year-four times the number of deaths caused by the use of all smuggled illegal drugs put together-but the UK government is not doing enough to tackle the problem.
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Vitamin D a key player in overall health of several body organs, says UC Riverside biochemist
Essential for life in higher animals, vitamin D, once linked to only bone diseases such as rickets and osteoporosis, is now recognized as a major player in contributing to overall human health, emphasizes UC Riverside's Anthony Norman, an international expert on vitamin D.
Clue to genetic cause of fatal birth defect
A novel enzyme may play a major role in anencephaly, offering hope for a genetic test or even therapy for the rare fatal birth defect in which the brain fails to develop, according to a study from researchers at the University of Illinois at Chicago College of Medicine.
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Researchers are still discovering new characteristics of Hodgkin lymphoma, a common form of cancer of the lymphatic system. The malignant cells are derived from white blood cells (B cells), but have lost a considerable part of the B cell-specific gene expression pattern.
Bisphenol A linked to chemotherapy resistance
Exposure to bisphenol A (BPA) may reduce the effectiveness of chemotherapy treatments, say University of Cincinnati (UC) scientists.
Fat injections can improve breast reconstruction -- jury's out on augmentation
Injecting fat after breast reconstruction to correct implant wrinkling or dimpling may be safe and effective to improve breast shape.
RNA molecules, delivery system improve vaccine responses, effectiveness
A novel delivery system that could lead to more efficient and more disease-specific vaccines against infectious diseases has been developed by biomedical engineers at The University of Texas at Austin.
Preventing colds: Washing your hands is more effective than taking vitamins
The days are getting shorter, temperatures are dropping, and the cold and flu season is beginning. Many people have started taking vitamin C tablets as a precautionary measure. But research has shown that vitamin supplements do not provide nearly as much protection as other measures, like frequently washing your hands - and that high doses can even be harmful.
Tamoxifen chemoprevention tied to early detection of breast cancer
The drug tamoxifen does not prevent or treat estrogen receptor (ER) negative breast cancer, but it can make the disease easier to find, researchers report in the Oct. 1 Journal of the National Cancer Institute.
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