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Concerns raised over policy to add folic acid to flour
November 20, 2001A UK Department of Health committee has now recommended universal fortification of flour with folic acid to reduce the level of neural tube defects. Yet researchers in this week's BMJ warn that we need to be cautious before introducing such a policy.
Although the benefits of supplementation are clear, the possible harms of such a policy are not, as there is no trial evidence of the efficacy and safety of the intervention, write child health experts, Brian Wharton and Ian Booth.
In the United States, a 19% reduction in the prevalence of neural tube defects has been reported following folic acid fortification of grain products. However, this reduction is less than half that seen in England and Wales in the 1980s without a fortification programme. These data are hardly a substitute for a controlled field trial, they argue.
Furthermore, mandatory and universal fortification does not, at present, need the same trial evidence as for a drug. Yet a drug is not given in imprecise doses to all members of the population without choice or indication, they add.
In 1998, 399 pregnancies in England and Wales were affected by central nervous system malformation. Although a field trial would not be easy, say the authors, is it acceptable to increase the folic acid intake of 50 million people to prevent a third to two thirds of these affected pregnancies before there is firm evidence of efficacy and safety in people who are not pregnant?
British Medical Journal (BMJ)
Furthermore, mandatory and universal fortification does not, at present, need the same trial evidence as for a drug. Yet a drug is not given in imprecise doses to all members of the population without choice or indication, they add.
In 1998, 399 pregnancies in England and Wales were affected by central nervous system malformation. Although a field trial would not be easy, say the authors, is it acceptable to increase the folic acid intake of 50 million people to prevent a third to two thirds of these affected pregnancies before there is firm evidence of efficacy and safety in people who are not pregnant?
British Medical Journal (BMJ)
Folic Acid Current Events and Folic Acid News RSSMortality Rates Reduced among Children Whose Mothers Received Iron-folic Acid Supplements
Offspring whose mothers had been supplemented with iron-folic acid during pregnancy had dramatically reduced mortality through age 7, according to researchers at the Johns Hopkins Bloomberg School of Public Health.
News brief: Effects of aspirin and folic acid on inflammation markers for colorectal adenomas
Unexpectedly, inflammation markers do not appear to be involved with the chemopreventative effect of aspirin on colorectal adenomas, according to a brief communication published online October 12 in the Journal of the National Cancer Institute.
Essential nutrient found in eggs may help lower risk of neural tube defects
Research published online in the journal Epidemiology found that higher levels of total blood choline are associated with a 2.5-fold reduction in risk for neural tube birth defects (NTDs).
Anti-epilepsy drug risk on cognitive function for unborn children
Interim results of a study being conducted by scientists at the University of Liverpool suggest that children aged three years and younger, who are born to women taking the anti-epileptic drug sodium valproate whilst pregnant, are likely to have an IQ of six to nine points lower than average.
Irish-led research team rule out link between specific antibodies and spina bifida
New research, published today in the New England Journal of Medicine, shows that a woman's risk of having a child with a neural tube defect (NTD), such as Spina Bifida, is not linked to folic acid related auto-antibodies.
Brain malformations significantly associated with preterm birth, Wake Forest research shows
New research out of Wake Forest University School of Medicine provides for the first time a solid scientific answer for the long-standing question of whether there is an association between preterm birth and brain malformations.
UCF researcher's nanoparticles could someday lead to end of chemotherapy
Nanoparticles specially engineered by University of Central Florida Assistant Professor J. Manuel Perez and his colleagues could someday target and destroy tumors, sparing patients from toxic, whole-body chemotherapies.
Some neural tube defects in mice linked to enzyme deficiency
Women of childbearing age can reduce the risk of having a child born with a neural tube defect such as spina bifida by eating enough folate or folic acid. However, folate prevents only about 70 percent of these defects.
Folic acid to prevent congenital heart defects
The Canadian policy of fortifying grain products with folic acid has already proved to be effective in preventing neural tube defects.
Taking folic acid for a year before pregnancy may reduce risk of preterm birth
Women who take folic acid supplements for at least one year before they become pregnant may cut their risk of having a premature baby by half, according to research published this week in the online journal, PLoS Medicine.
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Spring Valley - Folic Acid 400 mcg, 250 Tablets by Schiff Nutrition International. Folic Acid is a B vitamin and is one of the factors involved with vitamin B-12 in the production of new red blood cells and the synthesis of RNA and DNA, the carriers of genetic information. |
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Spring Valley - Folic Acid 800 mcg, 250 Tablets by Nature's Bounty, Inc. Folic Acid is a B vitamin and is one of the factors involved with vitamin B-12 in the production of new red blood cells and the synthesis of RNA and DNA, the carriers of genetic information. |
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Nature Made Folic Acid 600 mcg with DHA - 300 Softgels by Nature Made Folic acid, also known as folate and folacin, is essential in cell division, DNA synthesis, and the manufacturing of brain chemicals, or neurotransmitters in the body. Without adequate levels of folic acid, cells do not divide properly. Folic acid is vital to the development of the nervous system of a fetus. A deficiency of folic acid during pregnancy has been linked to several birth defects, such as the neural tube defect spina bifida. Therefore, it is critical for women of child-bearing age to consume 400 mcg of folic acid per day. In addition, folic acid may also play a significant role in heart health. It does so by helping to keep homocysteine levels down in the blood. Homocysteine is a substance that formed when Vitamin B12 and folic acid levels are low, and research has indicated... |
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Folic Acid 800 mcg 250 Caps by Swanson Premium Brand Vital nutrition for heart-health and more! Folic acid not only provides valuable protection for the cardiovascular system by helping control harmful homocysteine, it also plays an essential role in prenatal nutrition. According to the U.S. Public Health Service, a healthful diet supplying 400 mcg of folic acid per day may reduce a woman's risk of having a child with birth defects of the brain or spinal cord. Our convenient capsules are a great way to ensure that you get a healthy supply of folic acid every day. |
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Ortho Molecular Products - Folic Acid 5 mg - 120 Capsules by Ortho Molecular Products For many seeking high doses of Folic Acid, a Folic supplement containing 5 mg has been previously available only through prescription, even though Folic has never been a pharmacy-only ingredient. A required component for the conversion of Homocysteine to methionine, Folic Acid supplementation reduces Homocysteine levels as demonstrated in many clinical studies. Regardless of initial Homocysteine levels, increased folic acid supplementation (up to 800 mcg) has been shown in research to enhance an increased Homocysteine lowering effect. Those with higher initial Homocysteine levels had greater lowering effects with Folic Acid. Low levels of daily Folic Acid intake have been associated with high serum Homocysteine levels, especially in the elderly. Current research is showing that aggressive... |
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