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Widespread uncontrolled use of antibiotics to prevent anthrax will lead to resistance
October 31, 2001Giving antibiotics to large numbers of potentially exposed individuals to prevent anthrax will lead to resistance, according to researchers from Liverpool in this week's BMJ. As such, it is essential that they are used carefully and according to national guidelines.
Although generally safe, the antimicrobial drug ciprofloxacin, which has been purchased in large amounts by the US and several other national governments, is associated with tendon ruptures and neuropsychiatric disorders, and in most countries it is not licensed for use in pregnancy or children, say the authors. Furthermore, it's value has already been compromised by the development of resistance following over-use. We cannot exclude the possibility of the development of resistance in the anthrax bacterium, they write.
"The important thing is to ensure that prophylaxis is given only to those who really need it and discourage mass usage by an understandably alarmed public. To induce antimicrobial resistance on a mass scale would be an even greater triumph for the terrorists, they conclude."
British Medical Journal (BMJ)
British Medical Journal (BMJ)
Anthrax Current Events and Anthrax News RSSMilestone biodefense publication by Elsevier journal Vaccine
Last week during the 'Vaccines for Biothreats and Emerging and Neglected Diseases Symposium' in Galveston TX, USA, the Elsevier journal Vaccine released a supplement dedicated to vaccines for biodefense.
Cigarettes Harbor Many Bacteria Harmful to Human Health
Cigarettes are "widely contaminated" with bacteria, including some known to cause disease in people, concludes a new international study conducted by a University of Maryland environmental health researcher and microbial ecologists at the Ecole Centrale de Lyon in France.
New explanation for nature's hardiest life form
Got food poisoning? The cause might be bacterial spores, en extremely hardy survival form of bacteria, a nightmare for health care and the food industry and an enigma for scientists.
Better immune defense against anthrax
Scientists discover a gene in anthrax-causing bacteria may help defend against this form of bio-warfare.
Argonne researchers develop method that aims to stabilize antibodies
Researchers at the U.S. Department of Energy's Argonne National Laboratory have developed a systematic method to improve the stability of antibodies.
Early detection and quick response are key to defense against anthrax attack
A large attack on a major metropolitan area with airborne anthrax could affect more than a million people, necessitating their treatment with powerful antibiotics.
Data published in the New England Journal of Medicine support use of raxibacumab (ABthrax) for the treatment of inhalation anthrax
Human Genome Sciences, Inc. (Nasdaq: HGSI) today announced publication by the New England Journal of Medicine of the results of two pivotal animal efficacy studies, which showed the life-saving potential of the Company's human monoclonal antibody drug raxibacumab.
One secret to how TB sticks with you
Mycobacterium tuberculosis is arguably the world's most successful infectious agent because it knows how to avoid elimination by slowing its own growth to a crawl.
Unexpected discovery can open a new chapter in the fight against tuberculosis
A close relative of the microorganism that causes tuberculosis in humans has been found to form spores.
Genetic switch potential key to new class of antibiotics
Researchers have determined the structure of a key genetic mechanism at work in bacteria, including some that are deadly to humans, in an important step toward the design of a new class of antibiotics.
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Among the Living by Anthrax Pioneering metal band Anthrax, one of the genre's most influential, innovative and respected groups, melded the speed and fury of hardcore punk with the guitars and vocals of heavy metal to help create speed and thrash metal. Now what many consider the group's greatest album, 1987's "Among The Living," has been expanded with bonus tracks and a concert DVD, and digitally remastered for the first time, for the CD+DVD package AMONG THE LIVING (DELUXE EDITION) "Among The Living," originally produced by Eddie Kramer and Anthrax, was the band's third full-length album and featured the lineup of singer Joe Belladonna, lead guitarist Dan Spitz, rhythm guitarist Scott Ian, bassist Frank Bello and drummer Charlie Benante. Building on an underground following with signature tracks such as "I... |
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Among the Living by Anthrax If Metallica and Slayer invented speed metal, Anthrax brought it to the East Coast and imbued it with the attitude and excitement of New York hardcore. Among the Living is, without a doubt, their finest hour--a roaring, adrenaline-pumped collection of flailing beats, precise, razor-edged riffs and shout-along refrains. Unlike most full-throttle metal vocalists of the era, Joey Belladonna chose to sing as well as shout, giving songs like "Among the Living," "Indians" and "Efilnikcufecin" ("nice fuckin' life" spelled backwards) a decided melodic edge. Yet Scott Ian and Dan Spitz's buzzsaw guitar flurries, and Charlie Benante's insistent drumming, prevented the songs from ever degenerating into the run-of-the-mill heavy metal they so despised. --Jon Wiederhorn |
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Caught in a Mosh: BBC Live in Concert by Anthrax CAUGHT IN A MOSH: BBC LIVE IN CONCERT is the official U.S. debut release of the double CD set, which brings together two live performances from the 1987 UK "Among The Living" tour: their sold out Hammersmith Odeon show and their storming performance at the Donnington Festival. |
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We've Come for You All by Anthrax You'll find no rap metal or nu metal on We've Come for You All--just Anthrax's inimitable thrash-metal melded with contemporary melodies, dynamics, and booming, arena-worthy production. Two way-cool guests--Roger Daltrey and Pantera guitarist Dimebag Darrell--are under-utilized on their respective songs, but with machine-gun, heart-pounding double-bass drums and vocalist John Bush's convincing snarl, it hardly matters. Bush, who has been in Anthrax since the early '90s, has been part of much of the group's best and most mature (if not most commercially successful) material. The dynamic "Superhero" is a winner, as is the radio-ready, not-too-heavy "Safe Home." "Nobody Knows Anything" and "Strap It On" are the best of the heaviest entries. Effective acoustic moments, Scott Ian's guitar... |
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