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Tissue engineering for an ageing population.
August 30, 2001New products offering radical solutions to the medical problems of our ageing population will appear within the next 5-10 years, says Tim Hardingham speaking at the BA Festival of Science at the University of Glasgow today [3 September 2001].
Professor Hardingham, Head of the UK Centre for Tissue Engineering, a collaboration between the Universities of Manchester and Liverpool, says, “Tissue engineering products will tackle solutions to some of our chronic and debilitating medical conditions. New treatments will help reduce the problems associated with ulcers, burns, joint diseases and coronary heart disease. But these developments will inevitably come at a price and it is important that we consider how healthcare providers can best manage resources to make these technologies available for patient care.”
“With an ageing population, both in the UK and worldwide, there is expanding demand for better treatments for many clinical problems in the elderly,” says Professor Hardingham. “Tissue engineering is part of a brave new world of biomedicine in which our scientific understanding of how living cells function will enable us to gain control and direct their activity to promote the repair of damaged and diseased tissues,” he continues.
One important example of the potential application of tissue engineering in medicine is in the treatment of chronic persistent leg ulcers. For patients with diabetes, leg ulcers provide a constant source of discomfort and incapacity. Patients don’t lack the capacity to heal a skin wound – it’s just not happening at the site of the ulcer. “What are lacking are the biological signals, the chemical messengers and the physical cues, that initiate the events of cell migration, blood vessel formation and tissue assembly that characterise normal wound healing,” says Hardingham.
The tissue engineering technologies currently emerging from the biomedical research labs for transfer to the healthcare market are concerned with living tissues and harnessing living processes to achieve healing and repair where it is otherwise failing. The BBSRC, MRC4 and EPSRC3 funded Interdisciplinary Research Collaboration on Tissue Engineering is a new national centre, that brings together scientists at the Universities of Liverpool and Manchester. It complements other research across the UK in cell and tissue engineering.
From the research currently in progress, tissue engineering will deliver new medical techniques and devices, including small blood vessel replacement, bone, tendon, ligament and cartilage repair, healing of skin wounds, and advances in nerve regeneration. It will also lead to cellular based therapies for degenerative problems in muscle, for cardiac regeneration in the heart and in treating degenerative conditions in the brain.
For more information, go to the press paper at:
http://www.bbsrc.ac.uk/news/mediainfo.html#ba
Contact:
Professor Tim Hardingham, University of Manchester
tel: 0161 275 5511; e-mail: timothy.e.hardingham@man.ac.uk
Andrew McLaughlin, BBSRC
tel: 01793 413 301; mobile: 079 00 58 00 098 e-mail: andrew.mclaughlin@bbsrc.ac.uk
PRESS CONFERENCE:
Monday 3 September 2001
09.00 – 09.30 hrs.
Mackintosh Lecture Theatre, Hunterian Art Gallery, University of Glasgow.
Tissue engineering – Professor Tim Hardingham, University of Manchester
Bioartificial organs - Dr Helen Grant, University of Strathclyde
Gene therapy - Dr Michael Antoniou, King’s College London
Wound treatment - Dr Ian Kill, Brunel University
PHOTO OPPORTUNITIES:
Include bioartificial liver dialysis unit, sterilised pigskin for tissue engineering plus others.
Biotechnology and Biological Sciences Research Council (BBSRC)
One important example of the potential application of tissue engineering in medicine is in the treatment of chronic persistent leg ulcers. For patients with diabetes, leg ulcers provide a constant source of discomfort and incapacity. Patients don’t lack the capacity to heal a skin wound – it’s just not happening at the site of the ulcer. “What are lacking are the biological signals, the chemical messengers and the physical cues, that initiate the events of cell migration, blood vessel formation and tissue assembly that characterise normal wound healing,” says Hardingham.
The tissue engineering technologies currently emerging from the biomedical research labs for transfer to the healthcare market are concerned with living tissues and harnessing living processes to achieve healing and repair where it is otherwise failing. The BBSRC, MRC4 and EPSRC3 funded Interdisciplinary Research Collaboration on Tissue Engineering is a new national centre, that brings together scientists at the Universities of Liverpool and Manchester. It complements other research across the UK in cell and tissue engineering.
From the research currently in progress, tissue engineering will deliver new medical techniques and devices, including small blood vessel replacement, bone, tendon, ligament and cartilage repair, healing of skin wounds, and advances in nerve regeneration. It will also lead to cellular based therapies for degenerative problems in muscle, for cardiac regeneration in the heart and in treating degenerative conditions in the brain.
For more information, go to the press paper at:
http://www.bbsrc.ac.uk/news/mediainfo.html#ba
Contact:
Professor Tim Hardingham, University of Manchester
tel: 0161 275 5511; e-mail: timothy.e.hardingham@man.ac.uk
Andrew McLaughlin, BBSRC
tel: 01793 413 301; mobile: 079 00 58 00 098 e-mail: andrew.mclaughlin@bbsrc.ac.uk
PRESS CONFERENCE:
Monday 3 September 2001
09.00 – 09.30 hrs.
Mackintosh Lecture Theatre, Hunterian Art Gallery, University of Glasgow.
Tissue engineering – Professor Tim Hardingham, University of Manchester
Bioartificial organs - Dr Helen Grant, University of Strathclyde
Gene therapy - Dr Michael Antoniou, King’s College London
Wound treatment - Dr Ian Kill, Brunel University
PHOTO OPPORTUNITIES:
Include bioartificial liver dialysis unit, sterilised pigskin for tissue engineering plus others.
Biotechnology and Biological Sciences Research Council (BBSRC)
Tissue Engineering Current Events and Tissue Engineering News RSSBioengineering of nerve-muscle connection could improve hand use for wounded soldiers
Modern tissue engineering developed at the University of Michigan could improve the function of prosthetic hands and possibly restore the sense of touch for injured patients.
Major improvements made in engineering heart repair patches from stem cells
University of Washington (UW) researchers have succeeded in engineering human tissue patches free of some problems that have stymied stem-cell repair for damaged hearts.
New approach to wound healing may be easy on skin, but hard on bacteria
In a presentation today (Aug. 19) to the American Chemical Society meeting, Ankit Agarwal, a postdoctoral researcher at the University of Wisconsin-Madison, described an experimental approach to wound healing that could take advantage of silver's anti-bacterial properties, while sidestepping the damage silver can cause to cells needed for healing.
Researcher says microchannels could advance tissue engineering methods
Utilizing fractal patterns similar to those created by lightning strikes, Victor Ugaz, associate professor in the Artie McFerrin Department of Chemical Engineering at Texas A&M University, has created a network of microchannels that could advance the field of tissue engineering by serving as a three-dimensional vasculature for the support of larger tissue constructs, such as human organs.
Bone's material flaws lead to disease
The weak tendons and fragile bones characteristic of osteogenesis imperfecta, or brittle bone disease, stem from a genetic mutation that causes the incorrect substitution of a single amino acid in the chain of thousands of amino acids making up a collagen molecule, the basic building block of bone and tendon.
Skin-like Tissue Developed from Human Embryonic Stem Cells
Dental and tissue engineering researchers at Tufts University School of Dental Medicine and the Sackler School of Graduate Biomedical Sciences at Tufts have harnessed the pluripotency of human embryonic stem cells (hESC) to generate complex, multilayer tissues that mimic human skin and the oral mucosa (the moist tissue that lines the inside of the mouth).
Automated tissue engineering on demand
Skin from a factory - this has long been the dream of pharmacologists, chemists and doctors. Research has an urgent need for large quantities of 'skin models', which can be used to determine if products such as creams and soaps, cleaning agents, medicines and adhesive bandages are compatible with skin, or if they instead will lead to irritation or allergic reactions for the consumer.
Gene therapy appears safe to regenerate gum tissue
Scientists at the University of Michigan have developed a method of gene delivery that appears safe for regenerating tooth-supporting gum tissue-a discovery that assuages one of the biggest safety concerns surrounding gene therapy research and tissue engineering.
Human embryonic stem cells
Human embryonic stem cells (hESC) provide a potentially unlimited source of oral mucosal tissues that may revolutionize the treatment of oral diseases.
First tri-continuous mesoporous Silica complex structure developed in Singapore
Singapore's Institute of Bioengineering and Nanotechnology (IBN) has developed the first tri-continuous mesoporous material using a unique surfactant template.
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