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POSSIBLE EXPLANATION FOR FEVER AFTER PLATELET TRANSFUSION
June 20, 2001A preliminary study published in this week's issue of THE LANCET suggests a possible explanation for the biological process responsible for inducing fever and related symptoms after the transfusion of blood platelets.
Millions of platelet transfusions are done every year, and febrile (fever) reactions occur in around a third of cases. Most reactions are mild, but occasionally life-threatening lung failure can occur.
Richard Phipps comments: "If platelet soluble CD40 ligand is confirmed as the cause of these febrile responses, then we speculate that keeping the release of CD40 ligand to a minimum, or removing free CD40 ligand before transfusion, might effectively reduce adverse events after platelet transfusions. Moreover, individuals whose platelets are especially rich in CD40 ligand might prove less suitable as donors for transfusions."
Contact: Dr Richard Phipps, Department of Microbiology and Immunology, University of Rochester Cancer Center, Rochester, NY 14642, USA; t) +1 716-275-7836; F) +1 716 273 1042; E) Richard_Phipps@urmc.rochester.edu
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