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Hybrigenics Launches Pharma Industry’s First Proteomics Database For Hiv Drug Development Proprietary Hiv Bioinformatics Platform At Keystone Symposia Meeting

March 29, 2001

Paris, France - Hybrigenics, the functional proteomics company, announces the launch of the world’s most comprehensive combined protein-protein interactions “map” between the human immunodeficiency virus (HIV) and its host cell in humans. This represents the first time that a fully integrated HIV-Human protein pathway has been described; it is an invaluable tool to identify new drug targets against AIDS. The protein database known as PIMRider® HIV(1), will be launched today during a poster presentation at the Keystone Symposia HIV Pathogenesis meeting (Keystone, Colorado, USA), one of the world’s leading molecular and cellular biology research showcases.

Hybrigenics’ proprietary database will enable researchers for the first time to assign functions to proteins involved in interactions between the HIV virus and its human host cells, or lymphocytes. Combined analysis of these interactions allows deductions on the implication of various basic lymphocyte actions in the HIV replication cycle, as well as concerted actions of several viral proteins with the same cellular machinery. The identification of protein pathways is a key step to validating drug targets against HIV and developing therapeutics for treatment of HIV infections.

Based on its proprietary bioinformatics platform, Hybrigenics has compiled and integrated all the protein interaction information known and available in the scientific literature about the HIV to generate a powerful database resource. PIMRider® HIV includes published data concerning 132 interactions between all proteins contained in HIV-type 1 and 87 human cellular proteins, as well as useful bibliographic links to the human genome, HIV databases, description of sequences and structure of proteins.

This is the first time that HIV-lymphocyte protein interactions have been documented in a single database which allows researchers also to benefit from sophisticated visualization tools for insights into protein pathways, and provides the basis for therapeutic target validation. The resulting Protein Interaction Map (PIM®) includes the display of several functional pathways, and can be used to gather comprehensive biological annotations on interacting HIV and lymphocytes proteins.

“The launch of this unique database marks a major advance in the development of novel research strategies, and in the translation of HIV viral genomic data, into potentially useful vaccines and other therapeutics,” said Dr. Donny Strosberg, CEO of Hybrigenics. “We are confident that the unique ‘user-friendly’ visual presentation of this data – depicting a global picture of the virus and its protein-based relations with human host cells -- and the free subscription for our partners in the academic community worldwide, will help accelerate this important pursuit.”

W3C (World Wide Web Consortium)

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