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NO COMMON CAUSE LINKING INFLAMMATORY BOWEL DISEASE AND COLORECTAL CANCER (pp 246, 262)
January 24, 2001Research published in this week's issue of THE LANCET does not support the theory that there may be a single genetic cause for inflammatory bowel disease (IBD) and colorectal cancer.
The causes of IBD and colorectal cancer (which occurs more often in people with IBD) are unknown. Some researchers have suggested that IBD and colorectal cancer might share a common cause and, therefore, relatives of patients with IBD could be at an increased risk of this malignant disease. Johan Askling and colleagues from the Karolinska Institute, Stockholm, Sweden, aimed to assess cancer rates among first-degree relatives (parents, siblings, and offspring) of patients with IBD to try to establish whether an association between the two diseases exists.
The investigators identified around 114,000 first-degree relatives by registry linkage and followed them up for cancer occurrence. They compared incidence of cancer among the relatives with rates in the general population. 560 colorectal cancers were identified among relatives. First-degree relatives of patients with Crohn's disease or ulcerative colitis were neither at increased risk of cancer overall, nor at increased risk of colorectal cancer. Relatives of patients with both IBD and colorectal cancer had, however, an 80% increased risk of colorectal cancer.
In an accompanying Commentary (p 246), Fergus Shanahan from Cork University Hospital, Ireland, comments: "Colitis and colorectal cancer are more likely to have a cause-and-effect relation, which implies that optimum anti-inflammatory therapy will provide effective cancer prevention". He adds: "Although colitis and cancer do not share a common genetic cause, environmental factors such as smoking and the enteric bacterial flora may contribute to the pathogenesis of both processes".
Contact: Dr Johan Askling, Department of Medical Epidemiology, Karolinska Institute, BOX 281, S-171 77 Stockholm, Sweden; T) +46 8 728 6163; F) +46 8 314975; E) johan.askling@mep.ki.se
Professor Fergus Shanahan, Department of Medicine, Cork University Hospital, Cork, Ireland; T) +353 21 492 2221; F) +353 21 434 5300; E) fshanahan@ucc.ie
Lancet
In an accompanying Commentary (p 246), Fergus Shanahan from Cork University Hospital, Ireland, comments: "Colitis and colorectal cancer are more likely to have a cause-and-effect relation, which implies that optimum anti-inflammatory therapy will provide effective cancer prevention". He adds: "Although colitis and cancer do not share a common genetic cause, environmental factors such as smoking and the enteric bacterial flora may contribute to the pathogenesis of both processes".
Contact: Dr Johan Askling, Department of Medical Epidemiology, Karolinska Institute, BOX 281, S-171 77 Stockholm, Sweden; T) +46 8 728 6163; F) +46 8 314975; E) johan.askling@mep.ki.se
Professor Fergus Shanahan, Department of Medicine, Cork University Hospital, Cork, Ireland; T) +353 21 492 2221; F) +353 21 434 5300; E) fshanahan@ucc.ie
Lancet
Colorectal Cancer Current Events and Colorectal Cancer News RSS'Cross-talk' mechanism contributes to colorectal cancer
Researchers at the University of Wisconsin-Madison School of Medicine and Public Health have identified a molecular mechanism that allows two powerful signaling pathways to interact and begin a process leading to colorectal tumors.
African-Americans with colorectal cancer have poorer outcomes, lower survival rates
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Adding cetuximab to chemotherapy reduces advanced lung cancer death risk by 13 percent
Patients with advanced non-small cell lung cancer who are given cetuximab (Erbitux) in addition to chemotherapy are 13% less likely to die than those who receive chemotherapy alone, regardless of which chemotherapy drug cocktail is used, new research finds. They also experience slower disease progression and an increased chance of tumour shrinkage.
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