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Tuberculosis risk for travellers (pp 442, 461)

August 02, 2000

The risk of tuberculosis infection in long-term travellers to countries with high prevalence of the disease is substantial and of similar magnitude to the average risk for the local population, according to research published in this week’s issue of THE LANCET.

Little attention has been paid to the potential of international travellers to reintroduce tuberculosis into countries where the disease has become rare. Frank Cobelens and colleagues quantified the risk of Mycobacterium tuberculosis infection in 656 Dutch citizens who were about to visit an area of high tuberculosis prevalence (eg. Sub-Saharan Africa, Central America, or south-east Asia - where annual incidence is at least 1%) for a period of 3-12 months. Participants were skin tested for tuberculosis before departure, and those with negative results were tested again upon their return.

12 (1.8%) of the 656 individuals had an M tuberculosis infection on their return; the relative risk of tuberculosis infection was 3.7 times higher for health-care-worker travellers compared with non-health-care workers; the risk values were 7.9 per 1000 person-months of travel for health-care workers, and 2.8 per 1000 person-months of travel for non-health-care workers. The investigators conclude that BCG vaccination or post-travel tuberculin skin-testing of high-risk travellers should be considered.

In an accompanying Commentary (p 442), Alan Lifson discusses the pros and cons of different prevention strategies in these populations of travellers. He concludes that: “Today’s report of risk of tuberculosis infection to travellers highlights the links between the health of those in industrialised countries and the rest of the world”…”Whether one travels or not, tuberculosis teaches us that what happens in one part of the planet ultimately affects others elsewhere. Countries with more resources need to help resource-poor nations in their efforts to control this disease. Without global control of tuberculosis, no country or population is truly protected.”

Contact: Dr Frank Cobelens, Division of Infectious Diseases, Tropical Medicine & AIDS, Center for Tropical and Travel Medicine A01-331, Academic Medical Center, PO Box 22700, 1100 DE Amsterdam, Netherlands; T) +31 20 566 2929; F) +31 20 566 9061; E) f.g.cobelens@amc.uva.nl

Dr Henk van Deutekom, Tuberculosis Control Department, Amsterdam Municipal Health Service, Nieuwe Achtergracht 100, 1018 WT Amsterdam, Netherlands; T) +31 20 555 5240; E) HvDeutekom@gggd.amsterdam.nl

Dr Alan Lifson, Department of Infectious Diseases, University of Minnesota, MMC-250, 420 Delaware Street, SE Minneapolis, Minnesota 55455, USA; T) +1 612 624 9996; F) +1 612 625 4410; E) lifso001@umn.edu



Lancet




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