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FAMILY HISTORY OF HIGH CHOLESTEROL OFTEN NOT DETECTED UNTIL MIDDLE AGE
July 11, 2000Families with a history of high cholesterol are being denied early treatment to
reduce the risk of coronary events because they often remain undetected until
middle age, according to a study in this week?s BMJ.
Using specialist registers and general practice records, researchers in
Oxfordshire compared the number of families identified as having a history of
high cholesterol with the estimated frequency of the condition. They found that
only about a quarter of the cases predicted were diagnosed routinely, and most
remained undiagnosed until middle age. Lack of diagnosis was greatest among
children and young adults: only two children under 10 years and 12 aged 10-19
years had been identified.
These findings have important implications for clinical practice as, in families
with a history of high cholesterol, the risk of a coronary event by the age of
60 without effective treatment is at least 50% in men and about 30% in women.
Underdiagnosis means patients are denied early treatment to reduce their risk of
coronary events, say the authors. They suggest a number of strategies to tackle
this problem, such as routine testing of patients with early onset coronary
artery disease and family tracking and testing by specialist nurses. Systematic
screening of all 16 year olds may be equally cost effective, they add.
Warwick, University of
Cholesterol Current Events and Cholesterol News RSSFree e-samples of prescription drugs: At what cost?
Search the Internet to learn about your asthma, high cholesterol or other common disorder, and odds are you'll be directed to a pharmaceutical company-sponsored Web homepage.
Genetic analysis helps dissect molecular basis of cardiovascular disease
Using highly precise measurements of plasma lipoprotein concentrations determined by nuclear magnetic resonance spectroscopy (NMR), researchers led by Daniel Chasman at Brigham and Women's Hospital and Harvard Medical School in Boston, MA, the Framingham Heart Study in Framingham, and the PROCARDIS consortium in Stockholm, Sweden and Oxford, England performed genetic association analysis across the whole genome among 17,296 women of European ancestry from the Women's Genome Health Study.
New understanding about mechanism for cell death after stroke leads to possible therapy
Scientists at the Brain Research Centre, a partnership of the University of British Columbia Faculty of Medicine and Vancouver Coastal Health Research Institute, have uncovered new information about the mechanism by which brain cells die following a stroke, as well as a possible way to mitigate that damage.
Dispensing prescription drugs in 3-month supplies reduces drug costs by a third
Purchasing prescription drugs in a three-month supply rather than a one-month supply has long been regarded as a way to reduce the cost of drugs for patients and third-party payers. New research from the University of Chicago quantifies the savings for the first time.
The Protein Srebp2 Drives Cholesterol Formation in Prion-Infected Neuronal Cells Which May Promote Prion-Dependent Diseases
The regulating protein Srebp2 drives cholesterol formation, which prions need for their propagation, in prion-infected neuronal cells.
Pivotal study for PSD502 -- the first potential treatment for premature ejaculation
At the annual meeting of the Sexual Medicine Society of North America (SMSNA), Inc. in San Diego, Sciele Pharma, Inc., a Shionogi Company and Plethora Solutions Limited, a wholly owned subsidiary of Plethora Solutions Holdings PLC ("Plethora" - AIM:PLE)., today presented data from its second positive pivotal study of PSD502 for the treatment of premature ejaculation (PE).
Night Beat, Overtime and a Disrupted Sleep Pattern Can Harm Officers' Health
A police officer who works the night shift, typically from 8 p.m. to 4 a.m., already is at a disadvantage when it comes to getting a good "night's" sleep.
Vitamin B niacin offers no extra benefit to statin therapy in seniors already diagnosed with CAD
The routine prescription of extended-release niacin, a B vitamin (1,500 milligrams daily), in combination with traditional cholesterol-lowering therapy offers no extra benefit in correcting arterial narrowing and diminishing plaque buildup in seniors who already have coronary artery disease, a new vascular imaging study from Johns Hopkins experts shows.
Heart and bone damage from low vitamin D tied to declines in sex hormones
Researchers at Johns Hopkins are reporting what is believed to be the first conclusive evidence in men that the long-term ill effects of vitamin D deficiency are amplified by lower levels of the key sex hormone estrogen, but not testosterone.
Early end to key study on benefits of niacin, a B vitamin, in keeping arteries open was premature
Heart experts at Johns Hopkins are calling premature the early halt of a study by researchers at Walter Reed Army Medical Center and Washington Hospital Center on the benefits of combining extended-release niacin, a B vitamin, with cholesterol-lowering statin medications to prevent blood vessel narrowing.
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