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A New Startup Fund Called EMERTEC

June 20, 2000

Cantab Pharmaceuticals plc (LSE: CTB, Nasdaq: CNTBY) today announced the commencement of a Phase I clinical trial of TA-CIN, its novel vaccine candidate for the treatment of cervical dysplasia, an abnormality of the cervix associated with HPV infection, that can lead to cervical cancer if left untreated.

This initial safety and immunogenicity study is being conducted in 40 healthy volunteers at a clinical research centre in The Netherlands, and is designed to assess vaccine safety, tolerability, and to measure immunological responses. Volunteers receive a course of three monthly injections using either a high, medium or low dose formulation.'We are delighted to move TA-CIN into the clinic, after a challenging development programme.




This success now increases the number of Cantab's programmes in the clinic to five,' said Jurek Sikorski, Chief Executive Officer of Cantab. 'Cervical dysplasia affects more than 2% of the female population world-wide, and this vaccine addresses an unmet clinical need for a non-invasive treatment capable of eliminating the underlying cause of the disease.'Dr Nigel Whittle, Director of Project Management, added, 'Cervical dysplasia, which can affect women of all ages, has the potential to develop into a life threatening cancer and can currently only be treated by surgical intervention.

Through the successful development of our TA-CIN vaccine, Cantab aims to offer an effective and less intrusive treatment for cervical dysplasia.'Pre-clinical experimental work using TA-CIN carried out by Cantab in collaboration with the University of Leiden, The Netherlands, has produced encouraging results, with evidence to support both a strong therapeutic and prophylactic effect of the vaccine in animal model studies. Cervical dysplasia is a premalignant condition seen on the surface of the cervix. It is usually identified in women by the standard 'Pap' smear test and can, if left untreated, develop into cervical cancer, a condition that affects an estimated 15,000 women in the USA alone each year, causing up to 4,500 deaths.

The main cause of the disease is believed to be infection with human papillomavirus (HPV).TA-CIN vaccine is based on a genetically engineered fusion protein derived from HPV, and is designed to stimulate the human immune system to destroy cervical cells that are infected with HPV16. This is the type of HPV most commonly found in advanced stages of cervical dysplasia, and is generally considered to be a 'high-risk' type with respect to progression to cancer.


Noonan Russo Ltd



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