A New Startup Fund Called EMERTECJune 20, 2000Cantab Pharmaceuticals plc (LSE: CTB, Nasdaq: CNTBY) today announced the commencement of a Phase I clinical trial of TA-CIN, its novel vaccine candidate for the treatment of cervical dysplasia, an abnormality of the cervix associated with HPV infection, that can lead to cervical cancer if left untreated. This initial safety and immunogenicity study is being conducted in 40 healthy volunteers at a clinical research centre in The Netherlands, and is designed to assess vaccine safety, tolerability, and to measure immunological responses. Volunteers receive a course of three monthly injections using either a high, medium or low dose formulation.'We are delighted to move TA-CIN into the clinic, after a challenging development programme. This success now increases the number of Cantab's programmes in the clinic to five,' said Jurek Sikorski, Chief Executive Officer of Cantab. 'Cervical dysplasia affects more than 2% of the female population world-wide, and this vaccine addresses an unmet clinical need for a non-invasive treatment capable of eliminating the underlying cause of the disease.'Dr Nigel Whittle, Director of Project Management, added, 'Cervical dysplasia, which can affect women of all ages, has the potential to develop into a life threatening cancer and can currently only be treated by surgical intervention. Through the successful development of our TA-CIN vaccine, Cantab aims to offer an effective and less intrusive treatment for cervical dysplasia.'Pre-clinical experimental work using TA-CIN carried out by Cantab in collaboration with the University of Leiden, The Netherlands, has produced encouraging results, with evidence to support both a strong therapeutic and prophylactic effect of the vaccine in animal model studies. Cervical dysplasia is a premalignant condition seen on the surface of the cervix. It is usually identified in women by the standard 'Pap' smear test and can, if left untreated, develop into cervical cancer, a condition that affects an estimated 15,000 women in the USA alone each year, causing up to 4,500 deaths. The main cause of the disease is believed to be infection with human papillomavirus (HPV).TA-CIN vaccine is based on a genetically engineered fusion protein derived from HPV, and is designed to stimulate the human immune system to destroy cervical cells that are infected with HPV16. This is the type of HPV most commonly found in advanced stages of cervical dysplasia, and is generally considered to be a 'high-risk' type with respect to progression to cancer. Noonan Russo Ltd |
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| Related Cervical Cancer Current Events and Cervical Cancer News Articles 1 disease, not 1 demographic The Asian continent has nearly four billion people living in 47 different countries, and each of these groups has their own unique set of health issues. But when they come to the United States, they're often lumped into one large demographic: "Asian/Pacific Islander." Alternatively spliced tissue factor identified as promising new biomarker for aggressive cancers A recently discovered form of the protein that triggers blood clotting may play a key role in the molecular mechanisms leading to the growth of certain metastatic cancers, according to new research reported by an international team of scientists. M. D. Anderson redefines screening guidelines for breast, cervical and colorectal cancers Drawing on years of experience in cancer research and patient care, The University of Texas M. D. Anderson Cancer Center released today the most comprehensive, risk-based screening guidelines publicly available to date for breast, cervical and colorectal cancers. Study finds delay in follow-up among African-American women receiving abnormal breast finding A new analysis has identified a significant delay in follow-up times among African-American women after the finding of a suspicious breast abnormality. UIC study finds girls aware of HPV vaccine's benefits Contrary to concerns that the human papillomavirus vaccine might promote promiscuity, a national survey of girls and young women found that the majority of respondents did not believe the HPV vaccine protected them against other sexually transmitted infections. Scientists identify common HPV genotypes in northern India, encourage vaccination Although a wide spectrum of human papillomavirus is seen across the population of India, HPV-16 and HPV-18 are the most common types and a vaccination targeting these types could eliminate 75 percent of the cervical cancers in the region. Vaccinating boys against human papillomavirus not cost-effective Persistent infection with high-risk types of human papillomavirus (HPV), a sexually transmitted virus, is known to be a cause of cervical cancer. Vaccination and testing for the human papilloma virus could eradicate cervical cancer Cervical cancer could be eradicated within the next 50 years if countries implement national screening programmes based on detection of the human papilloma virus (HPV), which causes the disease, together with vaccination programmes against the virus, according to a cervical cancer screening expert. Targeted heat therapy offers new standard treatment option for soft tissue sarcoma Patients with soft-tissue sarcomas at high risk of spreading were 30% more likely to be alive and cancer free almost three years after starting treatment if their tumours were heated at the time they received chemotherapy, according to new research. Even in a safety net health system, colorectal cancer screening disparities remain Colorectal cancer screening rates are much lower among those in a safety net health system compared to the national average, and the number one predictor of screening is a combination of regular visits and insurance access. More Cervical Cancer Current Events and Cervical Cancer News Articles |
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