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World-famous cancer specialist links hormones to organ growth
March 07, 2000New work from internationally renowned cancer specialist Dr Judah Folkman indicates that organ size can be controlled by hormones. This important new finding may have implications for the treatment of a variety of conditions, including endometriosis, abnormal menstrual bleeding, and prostate conditions.
Dr Folkman, from the Children's Hospital and Harvard Medical School, in Boston, USA, rose to worldwide fame two years ago, with his work on control of cancer. He showed that by controlling the development of blood vessels in tumours (a process known as angiogenesis), you can stop tumour growth. Dr Folkman showed that proteins which inhibit angiogenesis are ultimately controlled by hormones. His original work on mice is now being replicated in patients.
Dr Folkman's new work shows that this method of controlling tumour size, by controlling the growth of nutrient-bringing blood vessels, may also may be a general way of regulating the size of all body tissues. Hormones stimulate cells in e.g. the prostate, to produce an angiogenic protein, which in turn causes growth of new blood vessels. These blood vessels set the conditions for organ growth. Understanding this process may help treatment of a range of conditions where organs suddenly increase in size, e.g. prostate conditions.
Because of this work, and because of his demonstration of the link between hormones and cancer, Dr Folkman will be receiving the prestigious Dale Medal at the British Endocrine Societies meeting in Birmingham.
Society for Endocrinology
Because of this work, and because of his demonstration of the link between hormones and cancer, Dr Folkman will be receiving the prestigious Dale Medal at the British Endocrine Societies meeting in Birmingham.
Society for Endocrinology
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