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Blood test to predict diabetes in children
January 18, 2000The researchers found that four out of five patients with juvenile diabetes have the so-called islet antibodies directed against GAD and IA2 in their blood before the condition manifests itself and that these proteins occur exclusively in cases of juvenile diabetes. The test measures the concentration of the islet antibodies in the child's blood. Researchers already established twenty-five years ago that juvenile diabetes could be predicted at an early stage by identifying islet antibodies, but the new test became practicable only after GAD and IA2 had been identified and could be synthesised.
The presence of the antibodies in the blood indicates that the cells which produce insulin are being broken down "unintentionally" by the immune system. The symptoms only manifest themselves when more than 80% of the insulin cells have already been destroyed by the immune system. By that time, the process of cell breakdown as a result of juvenile diabetes or type 1 diabetes has already been taking place for a number of years.
In addition to identifying the antibodies, the researchers use a DNA test to determine hereditary susceptibility to juvenile diabetes. By combining the DNA test and the antibody test, it is possible to determine -with an accuracy of more than 50%- whether a child belongs to the approximately 0.5% of the population who may develop juvenile diabetes. If only a DNA test were to be used, the accuracy rate would only be 1%. The new test makes it easier to study the process of juvenile diabetes development and to identify people in possible need of preventive treatment in later years.
NWO (Netherlands Organization for Scientific Research)
Diabetes Current Events and Diabetes News RSSFirst reconstitution of an epidermis from human embryonic stem cells
Stem cell research is making great strides. This is yet again illustrated by a study carried out by the I-STEM* Institute (I-STEM/ Inserm UEVE U861/AFM), published in the Lancet on 21 November 2009. The I-STEM team, directed by Marc Peschanski has just succeeded in recreating a whole epidermis from human embryonic stem cells.
An atomic-level look at an HIV accomplice
Since the discovery in 2007 that a component of human semen called SEVI boosts infectivity of the virus that causes AIDS, researchers have been trying to learn more about SEVI and how it works, in hopes of thwarting its infection-promoting activity.
Scripps research scientists find new link between insulin and core body temperature
A team led by scientists at The Scripps Research Institute have discovered a direct link between insulin-a hormone long associated with metabolism and metabolic disorders such as diabetes-and core body temperature.
Scientists find molecular trigger that helps prevent aging and disease
Researchers at Mount Sinai School of Medicine set out to address a question that has been challenging scientists for years: How do dietary restriction-and the reverse, overconsumption-produce protective effects against aging and disease?
Pivotal study for PSD502 -- the first potential treatment for premature ejaculation
At the annual meeting of the Sexual Medicine Society of North America (SMSNA), Inc. in San Diego, Sciele Pharma, Inc., a Shionogi Company and Plethora Solutions Limited, a wholly owned subsidiary of Plethora Solutions Holdings PLC ("Plethora" - AIM:PLE)., today presented data from its second positive pivotal study of PSD502 for the treatment of premature ejaculation (PE).
Night Beat, Overtime and a Disrupted Sleep Pattern Can Harm Officers' Health
A police officer who works the night shift, typically from 8 p.m. to 4 a.m., already is at a disadvantage when it comes to getting a good "night's" sleep.
Fat collections linked to decreased heart function
Researchers from Boston University School of Medicine (BUSM) have shown that fat collection in different body locations, such as around the heart and the aorta and within the liver, are associated with certain decreased heart functions.
Thoughtful words help couples stay fighting fit
Couples who bring thoughtful words to a fight release lower amounts of stress-related proteins, suggesting that rational communication between partners can ease the impact of marital conflict on the immune system.
Researchers discover mechanism of insulin production that can lead to better treatment for diabetes
How a specific gene within the pancreas affects secretion of insulin has been discovered by researchers from the Hebrew University of Jerusalem, in collaboration with Japanese and American universities.
Playing sport up to the end of pregnancy is healthy for the baby and the mother
Contrary to more conservative customs, exercising up to the end of pregnancy has no harmful effect on the weight or size of the foetus.
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