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Southampton study aims to pinpoint heart disease genes
May 26, 1999REF: 99/53
15 APRIL 1999
Southampton experts, funded by the British Heart Foundation, are to research genetic influences on coronary heart disease as part of a major new project, The Southampton Atherosclerosis Study.
Patients at Southampton General Hospital receiving heart examinations carried out using angiography--which reveals the presence of lesions in the arteries that supply blood to the heart--will be asked to participate in the study.
Volunteers will then be anonymously 'genotyped' to see whether a correlation can be drawn between variants of a certain gene (or combination of genes) and the severity of heart disease.
'It has been known for a long time that environmental factors, such as a high-fat diet and smoking, contribute to heart disease,' explains project leader Dr Shu Ye, of the University's Department of Human Genetics. 'However there are also a number of different genes which we believe may influence susceptibility and severity of heart disease.
'The Southampton Atherosclerosis Study will help us to gain a better understanding of the mechanisms which contribute to
heart disease. The results could also provide opportunities to identify high-risk individuals, and lead to the development of new preventative and therapeutic measures.'
Southampton, University of
Volunteers will then be anonymously 'genotyped' to see whether a correlation can be drawn between variants of a certain gene (or combination of genes) and the severity of heart disease.
'It has been known for a long time that environmental factors, such as a high-fat diet and smoking, contribute to heart disease,' explains project leader Dr Shu Ye, of the University's Department of Human Genetics. 'However there are also a number of different genes which we believe may influence susceptibility and severity of heart disease.
'The Southampton Atherosclerosis Study will help us to gain a better understanding of the mechanisms which contribute to
heart disease. The results could also provide opportunities to identify high-risk individuals, and lead to the development of new preventative and therapeutic measures.'
Southampton, University of
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Genetics for personalized coronary heart disease treatment
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Sometimes it's hard to tell friends from foes, biologically speaking. Naturally produced in the body, urokinase plasminogen activator and plasminogen interact to break up blood clots and recruit clean-up cells to clear away debris related to inflammation. In fact, urokinase manufactured as a drug effectively clears clogged arteries by generating clot-busting plasmin from blood-derived plasminogen.
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