Southampton study aims to pinpoint heart disease genesMay 26, 1999REF: 99/53 15 APRIL 1999 Southampton experts, funded by the British Heart Foundation, are to research genetic influences on coronary heart disease as part of a major new project, The Southampton Atherosclerosis Study. Patients at Southampton General Hospital receiving heart examinations carried out using angiography--which reveals the presence of lesions in the arteries that supply blood to the heart--will be asked to participate in the study.
Volunteers will then be anonymously 'genotyped' to see whether a correlation can be drawn between variants of a certain gene (or combination of genes) and the severity of heart disease. 'It has been known for a long time that environmental factors, such as a high-fat diet and smoking, contribute to heart disease,' explains project leader Dr Shu Ye, of the University's Department of Human Genetics. 'However there are also a number of different genes which we believe may influence susceptibility and severity of heart disease. 'The Southampton Atherosclerosis Study will help us to gain a better understanding of the mechanisms which contribute to heart disease. The results could also provide opportunities to identify high-risk individuals, and lead to the development of new preventative and therapeutic measures.' Southampton, University of | |||||||||||||||||||||
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Related Atherosclerosis Current Events and Atherosclerosis News Articles Estrogen therapy could be dangerous for women with existing heart risk Hormone therapy could accentuate certain pre-existing heart disease risk factors and a heart health evaluation should become the norm when considering estrogen replacement, new research suggests. Researchers identify how binge drinking may drive heart disease As the holidays arrive, a group of researchers has identified the precise mechanisms by which binge drinking contributes to clogs in arteries that lead to heart attack and stroke, according to a study published today in the journal Atherosclerosis. A scientific breakthrough on the control of the bad cholesterol A study performed by the team of Dr. Nabil G. Seidah, Director of the Biochemical Neuroendocrinology Research Unit at the IRCM, shows for the very first time that the degradation by PCSK9 of the LDLR receptor Bad cholesterol inhibits the breakdown of peripheral fat he so called bad cholesterol (LDL) inhibits the breakdown of fat in cells of peripheral deposits, according to a study from the Swedish medical university Karolinska Institutet. The discovery reveals a novel function of LDL as a regulator of fat turnover besides its well-established detrimental effects in promoting atherosclerosis. Vitamin C lowers levels of heart disease biomarker, finds study, adds to debate of health benefits A new study led by researchers at the University of California, Berkeley, adds to the evidence that vitamin C supplements can lower concentrations of C-reactive protein (CRP), a central biomarker of inflammation that has been shown to be a powerful predictor of heart disease and diabetes. Genetics for personalized coronary heart disease treatment Identifying a single, common variation in a person's genetic information improves prediction of his or her risk of a heart attack or other heart disease events and thus, choice of the best treatment accordingly, said researchers at Baylor College of Medicine in Houston. Low risk for heart attack? Could an ultrasound hold the answer? By adding the results of an imaging technique to the traditional risk factors for coronary heart disease, doctors at Baylor College of Medicine in Houston found they were able to improve prediction of heart attacks in people previously considered low risk. Low-dose aspirin does not appear to reduce risk of CV events in patients with diabetes Low-dose aspirin as primary prevention did not appear to significantly reduce the risk of a combined end point of coronary, cerebrovascular and peripheral vascular events in patients with type 2 diabetes, according to a new study in JAMA. Friend or foe? How the body's clot-busting system speeds up atherosclerosis Sometimes it's hard to tell friends from foes, biologically speaking. Naturally produced in the body, urokinase plasminogen activator and plasminogen interact to break up blood clots and recruit clean-up cells to clear away debris related to inflammation. In fact, urokinase manufactured as a drug effectively clears clogged arteries by generating clot-busting plasmin from blood-derived plasminogen. Mounting evidence shows health benefits of grape polyphenols A growing body of research data suggests that consuming foods rich in polyphenols from grapes, including red wine, helps reduce the risk of heart disease, according to a review article in the November issue of Nutrition Research. More Atherosclerosis Current Events and Atherosclerosis News Articles |
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