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Increased risk of coronary heart disease among UK Indian Asians may be genetic
April 26, 1999The increased rates of premature coronary heart disease among UK Indian Asians may be due to genetic or other as yet undiscovered risk factors, rather than the usual suspects, suggests research in Heart.
The rates of heart disease among this community, particularly in young men, are up to twice as high as those in European whites. Yet conventional risk factors, such as smoking, high cholesterol, and blood pressure are less common than they are in European whites.
The endothelial function of the major artery (brachial) in the arm was studied in 26 healthy Indian Asian and in 18 European white men between the ages of 35 and 60 who had no heart disease. Endothelial function refers to the ability of the cells lining the artery walls to expand and contract according to blood flow.
The results showed that endothelial function was impaired in Indian Asians, compared with European white men. This finding remained true whatever the level of substances, such as glucose, insulin, and cholesterol in their blood.
Previous research has indicated that a substance called nitric oxide, which is released from the endothelial cells, affects the dilation of the artery walls.
And the authors conclude that nitric oxide activity may be impaired in Indian Asians compared with European whites. Nitric oxide deficiency might contribute to tissue damage in the artery walls, creating the potential for inflammatory cells and the formation of life-threatening clots. The deficiency might itself be genetic, say the authors.
AlphaGalileo Foundation
The results showed that endothelial function was impaired in Indian Asians, compared with European white men. This finding remained true whatever the level of substances, such as glucose, insulin, and cholesterol in their blood.
Previous research has indicated that a substance called nitric oxide, which is released from the endothelial cells, affects the dilation of the artery walls.
And the authors conclude that nitric oxide activity may be impaired in Indian Asians compared with European whites. Nitric oxide deficiency might contribute to tissue damage in the artery walls, creating the potential for inflammatory cells and the formation of life-threatening clots. The deficiency might itself be genetic, say the authors.
AlphaGalileo Foundation
Heart Disease News and Current Heart Disease Events RSSClass of diabetes drugs carries significant cardiovascular risks
A class of oral drugs used to treat type 2 diabetes may make heart failure worse, according to an editorial published online in Heart Wednesday by two Wake Forest University School of Medicine faculty members.
Not all fat is created equal
A Temple University study finds fat in obese patients is "sick" when compared to fat in lean patients.
Young Type-2 Diabetic Men Suffer Low Testosterone Levels, Study Shows
Young men with type 2 diabetes have significantly low levels of testosterone, endocrinologists at the University at Buffalo have found -- a condition that could have a critical effect on their quality of life and on their ability to father children.
Early trigger for type-1 diabetes found in mice, Stanford scientists report
Scientists at the Stanford University School of Medicine are shedding light on how type-1 diabetes begins.
Chronic stress alters our genetic immune response
Most people would agree that stress increases your risk for illness and this is particularly true for severe long-term stresses, such as caring for a family member with a chronic medical illness.
New approach needed to tackle child abuse and neglect
Leading child advocates have called for a new approach to tackling child abuse and neglect amid rising rates of abuse notifications and children being brought into State care.
Chemists move closer toward developing safer, fully-synthetic form of heparin
Chemists are reporting a major advance toward developing a safer, fully-synthetic version of heparin, the widely used blood thinner now produced from pig intestines. The U. S. Food and Drug Administration last spring linked contaminated batches of the animal-based product, imported from China, to more than 80 deaths and hundreds of allergic reactions among patients exposed to the drug for kidney dialysis and other conditions.
Air pollution damages more than lungs: Heart and blood vessels suffer too
As athletes from around the world compete in the Beijing Olympics, many are on alert for respiratory problems caused by air pollution. They should also be concerned about its toxic effects on the heart and cardiovascular system, mounting research shows.
Aspirin, acid blocker a-day keeps GI bleeding
For patients with clogged heart arteries who take long-term, low-dose aspirin to prevent a cardiac event, adding a stomach acid-blocking drug to their daily routine has been shown to reduce their risk for upper gastrointestinal bleeding - an infrequent, but serious side-effect of regular aspirin use.
Gladstone scientists identify single microRNA that controls blood vessel development
Scientists from the Gladstone Institute of Cardiovascular Disease (GICD) and UCSF have identified a key regulatory factor that controls development of the human vascular system, the extensive network of arteries, veins, and capillaries that allow blood to reach all tissues and organs.
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