Potential dangers of long term tamoxifen useFebruary 12, 1999Tamoxifen prolongs the life of women with breast cancer and may significantly reduce the risk of developing the disease in those with an inherited tendency. But, suggests a leading article in the Journal of Clinical Pathology, long term use may produce other serious abnormalities, including cancer. These include hormonal-like effects on cervical smears, as well as increased numbers of polyps and pre-cancerous changes in the lining of the womb (endometrium)'all risk factors for the development of cancer. Several large trials have also indicated that women with breast cancer treated with the drug are at greater risk of developing endometrial cancer, and a small study showed that a type of endometrial cancer that has a poor prognosis was the one most commonly associated with treatment with tamoxifen. Increased numbers of cysts were found in the ovaries of women given tamoxifen. Women who have already gone through the menopause who are treated with the drug may develop endometriosis, a condition which is very rare in women of this age, and in which tissue from the womb lining ends up in other parts of the body. How tamoxifen produces these effects is not yet understood, says the author, but the publicity given to the benefits of tamoxifen looks set to increase the drug's use, not only among those with breast cancer, but also among healthy women with an inherited disposition to the disease. AlphaGalileo Foundation |
|||||||||||||||||||||
| Related Breast Cancer Current Events and Breast Cancer News Articles UCLA researchers create 'fly paper' to capture circulating cancer cells Just as fly paper captures insects, an innovative new device with nano-sized features developed by researchers at UCLA is able to grab cancer cells in the blood that have broken off from a tumor. Fertility procedures need not delay breast cancer treatment for younger women A new study published in the November issue of the Journal of the American College of Surgeons shows that breast cancer patients under 40 years old who undergo fertility preservation do not face a significant delay in the treatment of their disease when their care is coordinated in a timely fashion. Coffee break: Compound brewing new research in colon, breast cancer A compound in coffee has been found to be estrogenic in studies by Texas AgriLife Research scientists. Drugs to treat anemia in cancer patients linked to thromboembolism Medications frequently given to cancer patients to reduce their risk of anemia are associated with an increased risk of deep vein thrombosis or pulmonary embolism, according to new research led by Dawn Hershman, M.D, M.S., co-director of the breast cancer program at the Herbert Irving Comprehensive Cancer Center at NewYork-Presbyterian Hospital/Columbia University Medical Center. Discovery in worms by Queen's researchers points to more targeted cancer treatment Researchers at Queen's University have found a link between two genes involved in cancer formation in humans, by examining the genes in worms. The groundbreaking discovery provides a foundation for how tumor-forming genes interact, and may offer a drug target for cancer treatment. FDA approved leukemia drugs shows promise in ovarian cancer cells The drug Sprycel, approved for use by the U.S. Food and Drug Administration in patients with chronic myeloid leukemia, significantly inhibited the growth and invasiveness of ovarian cancer cells and also promoted their death, a study by researchers with UCLA's Jonsson Comprehensive Cancer Center found. Carnegie Mellon researchers link health-care debate to risk of dying in US and Europe The current health care debate in the United States is complicated. Trade-offs between heath care expenditures, lifestyle choices and life expectancy have been suggested but seldom clearly demonstrated. Scientists uncover new key to the puzzle of hormone therapy and breast cancer The use of postmenopausal hormone therapy has decreased over time in the United States, which researchers suggest may play a key role in the declining rate of atypical ductal hyperplasia, a known risk factor for breast cancer. Breast density associated with increased risk of cancer recurrence A new study finds that women treated for breast cancer are at higher risk of cancer recurrence if they have dense breasts. Published in the December 15, 2009 issue of Cancer, a peer-reviewed journal of the American Cancer Society, the study's results indicate that breast cancer patients with dense breasts may benefit from additional therapies following surgery, such as radiation. Researcher: 'Optical biopsy' for breast cancer increasingly accurate But women may not have to endure the medical costs, stress and potential complications that accompany such invasive biopsies forever. A University of Florida biomedical engineering researcher is making progress on an "optical biopsy" that has the potential to determine whether growths are cancerous without ever puncturing the skin. More Breast Cancer Current Events and Breast Cancer News Articles |
|||||||||||||||||||||
|
|||||||||||||||||||||
|
|||||||||||||||||||||